L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase.

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450.

1985 • 815 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Nitric oxide, a novel biologic messenger

1992 • 754 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Crystal structure of substrate-free Pseudomonas putida cytochrome P-450

1986 • 545 citations

Cytochrome P-450 and chloroperoxidase: thiolate-ligated heme enzymes. Spectroscopic determination of their active-site structures and mechanistic implications of thiolate ligation

1987 • 517 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

Coupling of spin, substrate, and redox equilibriums in cytochrome P450

1976 • 424 citations

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

1991 • 422 citations

Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer.

1993 • 411 citations

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

1991 • 386 citations

Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.

1992 • 368 citations

Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states.

1978 • 346 citations

Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.

1992 • 344 citations

Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate

1993 • 260 citations

Spectroscopic investigations of ferric cytochrome P-450-CAM ligand complexes. Identification of the ligand trans to cysteinate in the native enzyme.

1982 • 256 citations

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.

1990 • 240 citations

Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity

1992 • 174 citations

P450BM-3 and other Inducible Bacterial P450 Cytochromes: Biochemistry and Regulation

1991 • 170 citations

Calcium/calmodulin-dependent nitric oxide synthase type I: a biopteroflavoprotein with calcium/calmodulin-independent diaphorase and reductase activities

1992 • 151 citations

Optical difference spectrophotometry as a probe of rat brain nitric oxide synthase heme-substrate interaction

1993 • 149 citations

Haem-dependent activation of cytosolic guanylate cyclase by nitric oxide: a widespread signal transduction mechanism

1992 • 140 citations

Ligand binding to heme proteins. An evaluation of distal effects.

1983 • 119 citations

Heme coordination and structure of the catalytic site in nitric oxide synthase.

1993 • 99 citations

Nitric oxide gas: mediator, modulator, and pathophysiologic entity.

1992 • 88 citations

Carbon monoxide binding by Pseudomonas putida cytochrome P-450

1972 • 69 citations

Oxidation of NG-Hydroxy-L-arginine by Nitric Oxide Synthase: Evidence for the Involvement of the Heme in Catalysis

1993 • 62 citations

Spectroscopic, ligand binding, and enzymatic properties of the spleen green hemeprotein. A comparison with myeloperoxidase.

1985 • 48 citations

Rates of isonitrile binding to the isolated alpha and beta subunits of human hemoglobin.

1980 • 39 citations

Proton coupling in the ligand-binding reaction of ferric cytochrome P-450 from Pseudomonas putida

1983 • 6 citations

Deleted Work

1955 • 0 citations