Isolation and sequence of a cDNA clone which contains the complete coding region of rat phenylalanine hydroxylase. Structural homology with tyrosine hydroxylase, glucocorticoid regulation, and use of alternate polyadenylation sites.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

Yeast RNA Polymerase II Genes: Isolation with Antibody Probes

1983 • 1,084 citations

An interactive graphics program for comparing and aligning nucleic acid and amino acid sequences

1982 • 801 citations

Complete coding sequence of rat tyrosine hydroxylase mRNA.

1985 • 544 citations

THE PATHWAY OF EUKARYOTIC mRNA FORMATION

1983 • 429 citations

Nucleotide sequence of a full-length complementary DNA clone and amino acid sequence of human phenylalanine hydroxylase

1985 • 325 citations

Expression of Plasmodium falciparum blood-stage antigens in Escherichia coli: detection with antibodies from immune humans.

1983 • 211 citations

A simple purification of phenylalanine hydroxylase by substrate-induced hydrophobic chromatography.

1979 • 191 citations

Purification and Some Physical Properties of Phenylalanine Hydroxylase from Rat Liver

1970 • 162 citations

The Stimulation of Rat Liver Phenylalanine Hydroxylase by Lysolecithin and α-Chymotrypsin

1973 • 143 citations

Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains

1985 • 121 citations

Regulation of phenylalanine hydroxylase activity by phenylalanine in vivo, in vitro, and in perfused rat liver.

1982 • 71 citations

Relationship between the substrate activation site and catalytic site of phenylalanine hydroxylase.

1980 • 61 citations

Induction of metallothionein mRNA in rat liver and kidney after copper chloride injection

1985 • 60 citations

Amino acid sequence at the phosphorylated site of rat liver phenylalanine hydroxylase and phosphorylation of a corresponding synthetic peptide

1980 • 60 citations

Evidence for the Existence of Homologous Gene Coding Regions for the Catecholamine Biosynthetic Enzymes

1983 • 49 citations

The inhibition of glucose-stimulated insulin secretion by primary amines. A role for transglutaminase in the secretory mechanism

1984 • 46 citations

Purification and characterization of phenylalanine 4-monooxygenase from rat liver

1980 • 33 citations

Sequence comparison of rat liver phenylalanine hydroxylase and its cDNA clones

1984 • 32 citations

Distribution of phenylalanine hydroxylase (EC 1.14.3.1) in liver and kidney of vertebrates

1979 • 30 citations

Mechanism of tyrosine hydroxylase activation by phosphorylation

1982 • 25 citations

Cloning and Characterization of Rat-brain-specific Transcripts: Rare, Brain-specific Transcripts and Tyrosine Hydroxylase

1983 • 23 citations

Measurement of phenylalanine hydroxylase turnover in cultured hepatoma cells.

1979 • 22 citations

Genetics of the mammalian phenylalanine hydroxylase system. II. Immunological and two-dimensional gel electrophoretic studies of phenylalanine hydroxylase in cultured normal and mutant rat hepatoma cells

1979 • 20 citations

Aromatic Amino Acid Hydroxylases and Mental Disease

1980 • 20 citations

Identification of two molecular-mass forms of phenylalanine hydroxylase that segregate independently in rats. Specific association of each form with certain rat strains

1984 • 19 citations

Studies on the primary structure of rat liver phenylalanine hydroxylase

1985 • 13 citations

Translation of phenylalanine hydroxylase-specific mRNA in vitro: evidence for pretranslational control by glucocorticoids.

1981 • 12 citations

The two molecular weight forms of rat phenylalanine hydroxylase are encoded by different messenger RNAs.

1983 • 7 citations