Regional Angiogenesis Induced in Nonischemic Tissue by an Adenoviral Vector Expressing Vascular Endothelial Growth Factor

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Angiogenesis.

1992 • 2,581 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

1994 • 1,599 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.

1992 • 1,145 citations

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

1994 • 1,104 citations

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

1994 • 1,058 citations

Transfer of Genes to Humans: Early Lessons and Obstacles to Success

1995 • 1,023 citations

Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

1996 • 980 citations

The vascular endothelial growth factor family of polypeptides

1991 • 652 citations

Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs.

1994 • 616 citations

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.

1995 • 590 citations

Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis.

1994 • 570 citations

Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only.

1994 • 548 citations

Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis.

1993 • 502 citations

A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.

1995 • 480 citations

Cytostatic Gene Therapy for Vascular Proliferative Disorders with a Constitutively Active form of the Retinoblastoma Gene Product

1995 • 455 citations

Gene Therapy for Vascular Smooth Muscle Cell Proliferation After Arterial Injury

1994 • 443 citations

Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

1992 • 443 citations

Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis

1994 • 430 citations

Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis

1995 • 330 citations

Vascular endothelial growth factor: A new member of the platelet-derived growth factor gene family

1989 • 308 citations

Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus.

1994 • 285 citations

The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells.

1993 • 263 citations

Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis.

1993 • 262 citations

Efficient gene transfer into myocardium by direct injection of adenovirus vectors.

1993 • 257 citations

In vivo gene transfer and expression in normal uninjured blood vessels using replication-deficient recombinant adenovirus vectors.

1993 • 256 citations

Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo.

1993 • 255 citations

Vascular Endothelial Growth Factor Receptor Localization and Activation in Human Trophoblast and Choriocarcinoma Cells1

1994 • 246 citations

Effects of Vascular Endothelial Growth Factor on Hemodynamics and Cardiac Performance

1996 • 245 citations

Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors.

1994 • 241 citations

Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo.

1996 • 215 citations

Regulation of Vascular Endothelial Growth Factor in Cardiac Myocytes

1995 • 212 citations

Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development

1993 • 209 citations

“Sero-Switch” Adenovirus-MediatedIn VivoGene Transfer: Circumvention of Anti-Adenovirus Humoral Immune Defenses Against Repeat Adenovirus Vector Administration by Changing the Adenovirus Serotype

1996 • 207 citations

Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer.

1993 • 199 citations

Heparin modulates the interaction of VEGF165 with soluble and cell associated flk-1 receptors.

1994 • 194 citations

Molecular and biological properties of the vascular endothelial growth factor family of proteins

1992 • 193 citations

In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.

1994 • 184 citations

VEGF ₁₆₅ Expressed by a Replication-Deficient Recombinant Adenovirus Vector Induces Angiogenesis In Vivo

1995 • 159 citations

Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector.

1995 • 149 citations

Efficient and selective adenovirus-mediated gene transfer into vascular neointima.

1993 • 146 citations

Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver.

1996 • 136 citations

Transient Expression of Genes TransferredIn Vivointo Heart Using First-Generation Adenoviral Vectors: Role of the Immune Response

1995 • 132 citations

Percutaneous transluminal in vivo gene transfer by recombinant adenovirus in normal porcine coronary arteries, atherosclerotic arteries, and two models of coronary restenosis.

1994 • 126 citations

Arterial gene transfer to rabbit endothelial and smooth muscle cells using percutaneous delivery of an adenoviral vector.

1994 • 123 citations

Safety and efficacy of in vivo gene transfer into the porcine heart with replication-deficient, recombinant adenovirus vectors.

1996 • 120 citations

The Regulation of Blood Vessel Growth by Vascular Endothelial Growth Factor

1995 • 95 citations

Liposuction-derived human fat used for vascular graft sodding contains endothelial cells and not mesothelial cells as the major cell type

1994 • 93 citations

Systematic Analysis of Repeated Gene Delivery into Animal Lungs with a Recombinant Adenovirus Vector

1996 • 89 citations

Gene transfer and vascular disease

1994 • 76 citations

Chronic Hypoxia Differentially Regulates α ₁ -Adrenergic Receptor Subtype mRNAs and Inhibits α ₁ -Adrenergic Receptor–Stimulated Cardiac Hypertrophy and Signaling

1995 • 51 citations

Cardiac gene transfer by intracoronary infusion of adenovirus vector—mediated reporter gene in the transplanted mouse heart

1996 • 50 citations

In vivo adenovirus-mediated gene transfer to lungs via pulmonary artery

1994 • 49 citations

Adenoviral Vector-Mediated Gene Transfer into Sheep Arteries Using a Double-Balloon Catheter

1994 • 49 citations

Developmental failure of chimeric embryos expressing high levels of H-2Dd transplantation antigens.

1992 • 23 citations

MULTIPLE VECTORS EFFECTIVELY ACHIEVE GENE TRANSFER IN A MURINE CARDIAC TRANSPLANTATION MODEL IMMUNOSUPPRESSION WITH TGF-β OR vIL-10

1995 • 11 citations

Correlation between fructose 2,6-bisphosphate and lactate production in skeletal muscle

1994 • 8 citations