Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

1997 • 1,590 citations

Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor

1977 • 1,422 citations

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

1990 • 1,147 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

1999 • 1,044 citations

Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells

1991 • 626 citations

Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice.

1999 • 599 citations

Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells

1992 • 530 citations

Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

1997 • 512 citations

Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice.

1988 • 462 citations

Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate

1998 • 455 citations

Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis.

1996 • 411 citations

Expression of Angiogenesis-Related Genes and Progression of Human Ovarian Carcinomas in Nude Mice

1998 • 377 citations

Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor.

1996 • 350 citations

Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF ₁₂₁ and VEGF ₁₆₅ but not VEGF ₁₈₉

1997 • 224 citations

Regulation of distinct steps of angiogenesis by different angiogenic molecules.

1998 • 208 citations

Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo

1998 • 207 citations

Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.

1998 • 201 citations

Pathogenesis of ascites tumor growth: angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining.

1995 • 165 citations

Organ site-dependent expression of basic fibroblast growth factor in human renal cell carcinoma cells.

1994 • 136 citations

Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts.

1998 • 136 citations

Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma.

1999 • 124 citations

Evidence that the process of murine melanoma metastasis is sequential and selective and contains stochastic elements.

1986 • 116 citations

Site-specific metastasis of mouse melanomas and a fibrosarcoma in the brain or meninges of syngeneic animals.

1988 • 113 citations

An antagonistic vascular endothelial growth factor (VEGF) variant inhibits VEGF-stimulated receptor autophosphorylation and proliferation of human endothelial cells

1998 • 77 citations

Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by cell density.

1996 • 76 citations

Surgical treatment of metastatic brain tumors

1996 • 72 citations

Anti-angiogenesis Therapy and Strategies for Integrating It with Adjuvant Therapy

1998 • 57 citations

Different Deficiencies in the Prevention of Tumorigenic-Low-Metastatic Murine K-1735b Melanoma Cells From Producing Metastases<xref ref-type="fn" rid="FN2">2</xref>

1986 • 54 citations

Down-regulation of vascular endothelial growth factor in human colon carcinoma cell lines by antisense transfection decreases endothelial cell proliferation

1996 • 54 citations

Cross-linked envelope-related markers for squamous differentiation in human lung cancer cell lines.

1990 • 45 citations

Malignant potential of cells isolated from lymph node or brain metastases of melanoma patients and implications for prognosis.

1991 • 41 citations

Brain Metastasis: Role of Trophic, Autocrine, and Paracrine Factors in Tumor Invasion and Colonization of the Central Nervous System

1996 • 40 citations

Model of malignant pleural effusion of human lung adenocarcinoma in SCID mice.

1997 • 37 citations

Cell density-dependent regulation of basic fibroblast growth factor expression in human renal cell carcinoma cells.

1996 • 37 citations

Prevention of intestinal toxic effects and intensification of irinotecan's therapeutic efficacy against murine colon cancer liver metastases by oral administration of the lipopeptide JBT 3002.

1998 • 30 citations

CRITICAL FACTORS REGULATING SITE-SPECIFIC BRAIN METASTASIS OF MURINE MELANOMAS

1993 • 26 citations

Vascular-derived growth factors: potential role in the development of the tumour vasculature

1997 • 6 citations