Glutamine Deprivation Induces the Expression ofGADD45 and GADD153 Primarily by mRNA Stabilization

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Current protocols in molecular biology

1988 • 7,584 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1988 • 1,292 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153)

1996 • 671 citations

Rapid colormetric assay for cell viability: Application to the quantitation of cytotoxic and growth inhibitory lymphokines

1984 • 561 citations

The Nonamer UUAUUUAUU Is the Key AU-Rich Sequence Motif That Mediates mRNA Degradation

1995 • 524 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

The Glucose-Regulated Proteins (GRP78 and GRP94): Functions, Gene Regulation, and Applications

1994 • 391 citations

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1994 • 331 citations

AUUUA Is Not Sufficient To Promote Poly(A) Shortening and Degradation of an mRNA: the Functional Sequence within AU-Rich Elements May Be UUAUUUA(U/A)(U/A)

1994 • 331 citations

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells

1996 • 317 citations

Stress-Induced Binding of the Transcription Factor CHOP to a Novel DNA Control Element

1996 • 305 citations

AUF1 Binding Affinity to A+U-rich Elements Correlates with Rapid mRNA Degradation

1996 • 258 citations

Characterization of the stress-inducing effects of homocysteine

1998 • 231 citations

Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1.

1995 • 229 citations

The p53-dependent gamma-ray response of GADD45.

1994 • 225 citations

Amino Acid Limitation Induces Expression of CHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

1997 • 203 citations

Regulation of the C/EBP-related gene gadd153 by glucose deprivation.

1993 • 190 citations

Activation of the gadd153 promoter by genotoxic agents: a rapid and specific response to DNA damage.

1992 • 175 citations

Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins.

1992 • 173 citations

Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I.

1991 • 151 citations

Effect of amino acid limitation on the expression of 19 genes in rat hepatoma cells

1994 • 140 citations

Characterization of human Gadd45, a p53-regulated protein.

1994 • 126 citations

Genotoxic stress confers preferential and coordinate messenger RNA stability on the five gadd genes.

1994 • 120 citations

Increased gadd153 messenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide.

1997 • 100 citations

Determinants of glutamine dependence and utilization by normal and tumor-derived breast cell lines

1998 • 92 citations

DNA damage inducible-gene expression following platinum treatment in human ovarian carcinoma cell lines

1996 • 74 citations

The molecular response to reductive stress in LLC-PK1 renal epithelial cells: coordinate transcriptional regulation of gadd153 and grp78 genes by thiols

1997 • 37 citations

Origin, concentration and structural features of human mammary gland cells cultured from breast secretions

1976 • 35 citations

Modifications of p53 Protein and Accumulation of p21 and gadd45 mRNA in TGF-β1 Growth Inhibited Cells

1997 • 30 citations

Quinone thioether-mediated DNA damage, growth arrest, and gadd153 expression in renal proximal tubular epithelial cells.

1996 • 23 citations

Down-regulation of gadd153 by c-myc in rat fibroblasts and its effect on cell growth and radiation-induced apoptosis.

1996 • 18 citations

Cytogenetic characterization of two human milk-derived cell line (HBL-100) passages differing in tumorigenicity.

1990 • 9 citations