Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

The metabolic and molecular bases of inherited disease

2001 • 6,883 citations

Role of LXRs in control of lipogenesis

2000 • 1,623 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

The Metabolic Basis of Inherited Disease.

1972 • 1,407 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

Vitamin D Receptor As an Intestinal Bile Acid Sensor

2002 • 1,100 citations

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

1995 • 1,089 citations

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids

2001 • 736 citations

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation ofCYP3A4by Rifampicin through a Distal Enhancer Module

1999 • 645 citations

Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification

2002 • 642 citations

Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

2000 • 503 citations

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 • 487 citations

Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis.

1991 • 479 citations

Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression.

1990 • 467 citations

Redundant Pathways for Negative Feedback Regulation of Bile Acid Production

2002 • 462 citations

The Metabolic Basis of Inherited Disease.

1991 • 409 citations

Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450

2001 • 381 citations

Loss of Nuclear Receptor SHP Impairs but Does Not Eliminate Negative Feedback Regulation of Bile Acid Synthesis

2002 • 346 citations

Identification of a Bile Acid-responsive Element in the Human Ileal Bile Acid-binding Protein Gene

1999 • 343 citations

Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors

2002 • 336 citations

Regulation ofCYP3AGene Transcription by the Pregnane X Receptor

2002 • 325 citations

Markedly Reduced Bile Acid Synthesis but Maintained Levels of Cholesterol and Vitamin D Metabolites in Mice with Disrupted Sterol 27-Hydroxylase Gene

1998 • 263 citations

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 • 260 citations

Marked reduction in bile acid synthesis in cholesterol 7α-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia

1998 • 251 citations

Disruption of Cholesterol 7α-Hydroxylase Gene in Mice

1996 • 230 citations

Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver

2000 • 226 citations

Disruption of the Sterol 27-Hydroxylase Gene in Mice Results in Hepatomegaly and Hypertriglyceridemia

2000 • 198 citations

Orphan Receptor Promiscuity in the Induction of Cytochromes P450 by Xenobiotics

2001 • 107 citations

The bile acid synthetic gene 3β-hydroxy-Δ5-C27-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis

2000 • 103 citations

Side Chain Hydroxylations in Bile Acid Biosynthesis Catalyzed by CYP3A Are Markedly Up-regulated in Cyp27 Mice but Not in Cerebrotendinous Xanthomatosis

2001 • 81 citations

Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27−/− mice and CTX

2001 • 66 citations

A novel pathway for biosynthesis of cholestanol with 7 alpha-hydroxylated C27-steroids as intermediates, and its importance for the accumulation of cholestanol in cerebrotendinous xanthomatosis.

1985 • 65 citations

Biosynthesis of bile acids in cerebrotendinous xanthomatosis. Relationship of bile acid pool sizes and synthesis rates to hydroxylations at C-12, C-25, and C-26.

1985 • 47 citations

Sterol 27-hydroxylase Deficiency: A Rare Cause of Xanthomas in Normocholesterolemic Humans

2000 • 46 citations

Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5β-cholestane-3α,7α,12α-triol in human liver microsomes

1999 • 46 citations

Biosynthesis of cholestanol: Conversion of cholesterol into 4-cholesten-3-one by rat liver microsomes

1974 • 27 citations