Back to search

Immunodepression in sepsis and SIRS assessed by ex vivo cytokine production is not a generalized phenomenon: a review.

Data up to Jan 2025

Published2001
Citations122
References79

Total Citations Per Year

Abstract

References (79)

Sepsis: A New Hypothesis for Pathogenesis of the Disease Process

1997 • 1,014 citations

Dysregulation of in vitro cytokine production by monocytes during sepsis.

1991 • 747 citations

POST-INJURY MULTIPLE ORGAN FAILURE: THE ROLE OF THE GUT

2001 • 538 citations

Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia.

1996 • 522 citations

Normal Responses to Injury Prevent Systemic Inflammation and Can Be Immunosuppressive

2001 • 514 citations

Major Injury Leads to Predominance of the T Helper-2 Lymphocyte Phenotype and Diminished Interleukin-12 Production Associated with Decreased Resistance to Infection

1995 • 503 citations

Role of NFkappaB in the mortality of sepsis.

1997 • 464 citations

Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta.

1995 • 459 citations

The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome

1999 • 428 citations

Regulation of tumor necrosis factor production by adrenaline and beta-adrenergic agonists.

1992 • 385 citations

Distinct mechanisms of immunosuppression as a consequence of major surgery

1997 • 336 citations

Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.

1994 • 315 citations

Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: comparison with interleukin-1.

1992 • 300 citations

Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis

1996 • 263 citations

In vivo inhibition of nuclear factor-kappa B activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock.

1997 • 258 citations

Compartmentalized cytokine production within the human lung in unilateral pneumonia.

1994 • 253 citations

Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease

1997 • 239 citations

Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study

1995 • 236 citations

Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes.

1996 • 229 citations

Inadequate Interleukin 2 Production

1984 • 211 citations

Pro-opiomelanocortin-derived peptides induce IL-10 production in human monocytes.

1996 • 197 citations

Hemorrhagic Shock Primes for Increased Expression of Cytokine-Induced Neutrophil Chemoattractant in the Lung: Role in Pulmonary Inflammation Following Lipopolysaccharide

1998 • 196 citations

Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans.

1993 • 195 citations

NF- κ B Expression in Mononuclear Cells of Patients with Sepsis Resembles That Observed in Lipopolysaccharide Tolerance

2000 • 192 citations

Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome.

1993 • 192 citations

Downregulation of T helper type 1 immune response and altered pro-inflammatory and anti-inflammatory T cell cytokine balance following conventional but not laparoscopic surgery11This work was supported by DFG grants Si 208/5-1 and Si 208/5-4 to the clinical research group, “Immunosuppression und Postoperative Sepsis.”

1999 • 179 citations

Differential Expression of Proinflammatory Cytokines and Their Inhibitors during the Course of Meningococcal Infections

1994 • 175 citations

Elevated lnterleukin-1 Release by Human Alveolar Macrophages during the Adult Respiratory Distress Syndrome

1989 • 162 citations

NF-κB REGULATORY MECHANISMS IN ALVEOLAR MACROPHAGES FROM PATIENTS WITH ACUTE RESPIRATORY DISTRESS SYNDROME

2000 • 159 citations

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit endotoxin-induced TNF-alpha production by macrophages: in vitro and in vivo studies.

1999 • 155 citations

Compartmentalised inducible nitric-oxide synthase activity in septic shock

2000 • 153 citations

Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock

1995 • 153 citations

Mechanisms of lung neutrophil activation after hemorrhage or endotoxemia: roles of reactive oxygen intermediates, NF-kappa B, and cyclic AMP response element binding protein.

1999 • 148 citations

Pyrrolidine dithiocarbamate prevents I-kappaB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs.

1999 • 145 citations

Monocyte response to bacterial toxins, expression of cell surface receptors, and release of anti-inflammatory cytokines during sepsis

1996 • 139 citations

Reduced Ex Vivo Interleukin-8 Production by Neutrophils in Septic and Nonseptic Systemic Inflammatory Response Syndrome

1998 • 115 citations

Inhibition of the Defense System Stimulating Interleukin-12 Interferon-γ Pathway During Critical Illness

1997 • 115 citations

Decreased serum interleukin 1 activity and monocyte interleukin 1 production in patients with fatal sepsis

1986 • 112 citations

Influence of serotonin on the immune response.

1985 • 107 citations

Regulation of interleukin‐10 production by β‐adrenergic agonists

1996 • 102 citations

Endotoxin tolerance is not a LPS-specific phenomenon: partial mimicry with IL-1, IL-10 and TGFβ

1994 • 101 citations

Impaired activation of nuclear factor-kappaB in endotoxin-tolerant rats is associated with down-regulation of chemokine gene expression and inhibition of neutrophilic lung inflammation.

1997 • 100 citations

Induction of Global Anergy Rather Than Inhibitory Th2 Lymphokines Mediates Posttrauma T Cell Immunodepression

2000 • 96 citations

Different Pattern of Local and Systemic Release of Proinflammatory and Anti-inflammatory Mediators in Severely Injured Patients with Chest Trauma

1996 • 92 citations

Role of Interleukin 6 and Transforming Growth Factor–β in the Induction of Depressed Splenocyte Responses Following Sepsis

1993 • 81 citations

Long-term-impaired expression of nuclear factor-kappa B and I kappa B alpha in peripheral blood mononuclear cells of trauma patients.

2001 • 69 citations

The release of transforming growth factor-beta following haemorrhage: its role as a mediator of host immunosuppression.

1993 • 68 citations

Elevated Tumor Necrosis Factorα Production Concomitant to Elevated Prostaglandin E2 Production by Trauma Patients' Monocytes

1990 • 65 citations

Reduced Th1, but Not Th2, Cytokine Production by Lymphocytes after In Vivo Exposure of Healthy Subjects to Endotoxin

2000 • 64 citations

Early Activation of Hepatic NFκB and NF-IL6 in Polymicrobial Sepsis Correlates With Bacteremia, Cytokine Expression, and Mortality

1999 • 60 citations

Activation of Extracellular Signal-Regulated Kinases, NF-κB, and Cyclic Adenosine 5′-Monophosphate Response Element-Binding Protein in Lung Neutrophils Occurs by Differing Mechanisms After Hemorrhage or Endotoxemia

2001 • 60 citations

Expression of Tumor Necrosis Factor-α Gene in Alveolar Macrophages from Patients with the Adult Respiratory Distress Syndrome

1993 • 59 citations

Cytokines and Soluble Cytokine Receptors in Pleural Effusions from Septic and Nonseptic Patients

1997 • 58 citations

Endotoxin‐stimulated peritoneal macrophages obtained from continuous ambulatory peritoneal dialysis patients show an increased capacity to release interleukin‐1βin vitro during infectious peritonitis

1990 • 57 citations

Endotoxin administration to humans primes alveolar macrophages for increased production of inflammatory mediators

1994 • 55 citations

Increase in the Production of Interleukin‐6, Interleukin‐10, and Interleukin‐12 by Lipopolysaccharide‐Stimulated Peritoneal Macrophages from Women with Endometriosis

1999 • 52 citations

Induction of endotoxin tolerance depletes nuclear factor-κB and suppresses its activation in rat alveolar macrophages

1997 • 50 citations

EX VIVO T-LYMPHOCYTE DERIVED CYTOKINE PRODUCTION IN SIRS PATIENTS IS INFLUENCED BY EXPERIMENTAL PROCEDURES

2000 • 50 citations

N-Acetyl-leucinyl-leucinyl-norleucinal Inhibits Lipopolysaccharide-Induced NF-κB Activation and Prevents TNF and IL-6 Synthesisin Vivo

1997 • 47 citations

Altered IL-10 levels in trauma patients' M� and T lymphocytes

1995 • 44 citations

Major Surgery Suppresses Maximal Production of Helper T-Cell Type 1 Cytokines Without Potentiating the Release of Helper T-Cell Type 2 Cytokines

1999 • 43 citations

Early Activation of Pulmonary Nuclear Factor kappa B and Nuclear Factor Interleukin-6 in Polymicrobial Sepsis

1999 • 42 citations

α-Melanocyte-Stimulating Hormone as a Mediator of Tolerance Induction

1999 • 41 citations

Dose- and time-dependent changes in plasma catecholamines in response to endotoxin in conscious rats.

1989 • 40 citations

Autocrine modulation of IL-8 production by sputum neutrophils in chronic bronchial sepsis.

1997 • 40 citations

Prostaglandin E2 down-regulation of T cell IL-2 production is independent of IL-10 during gram-negative sepsis

1999 • 39 citations

Interleukin-1 receptor antagonist production during infectious and noninfectious systemic inflammatory response syndrome

2000 • 37 citations

Sepsis facilitates brain serotonin activity and impairs learning ability in rats

1999 • 31 citations

Compartmentalization of TNF and IL‐6 in meningitis and septic shock

1993 • 28 citations

Participation of Serotoninergic System in Neuroimmunomodulation: Intraimmune Mechanisms and the Pathways Providing an Inhibitory Effect

1988 • 27 citations

THE mRNA EXPRESSION AND IN VITRO PRODUCTION OF CYTOKINES AND OTHER PROTEINS BY HEPATOCYTES AND KUPFFER CELLS FOLLOWING THERMAL INJURY

1995 • 26 citations

Reduced Ex Vivo Chemokine Production by Polymorphonuclear Cells after In Vivo Exposure of Normal Humans to Endotoxin

2000 • 25 citations

Peritoneal macrophages show increased cytokine gene expression following haemorrhagic shock.

1994 • 25 citations

Reduced Tumor Necrosis Factor α Production in Lipopolysaccharide-Treated Whole Blood From Patients in the Intensive Care Unit

1994 • 24 citations

ELEVATED IL-8 PRODUCTION BY TRAUMA PATIENTS' MONOCYTES IS ASSOCIATED WITH ELEVATED SECRETION OF TNFα

1995 • 22 citations

Interleukin-1 production from peripheral blood monocytes in septic infections in children

1991 • 18 citations

INTERLEUKIN 10 PRODUCTION IN PATIENTS UNDERGOING CARDIOPULMONARY BYPASS: EVIDENCE OF INHIBITION OF Th-1-TYPE RESPONSES

1999 • 17 citations

Induction of Tolerance to Hemorrhagic or Endotoxic Shock Involves Activation of NF-κB

1999 • 16 citations

Dithiocarbamates Ameliorate the Effects of Endotoxin in a Rabbit Model of Disseminated Intravascular Coagulation

1999 • 11 citations

Cited By (0)

Loading...
Immunodepression in sepsis and SIRS assessed by ex vivo cytokine production is not a… (2001) – PubMed | Metascience Observatory Explorer