A Role for the α-Chain Connecting Peptide Motif in Mediating TCR-CD8 Cooperation

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

1979 • 522 citations

Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system.

1992 • 511 citations

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

1989 • 447 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

1995 • 245 citations

Qualitative and Quantitative Differences in T Cell Receptor Binding of Agonist and Antagonist Ligands

1999 • 226 citations

CD3delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

1997 • 209 citations

A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

2000 • 203 citations

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

2000 • 194 citations

Derivation of a T cell hybridoma variant deprived of functional T cell receptor α and β chain transcripts reveals a nonfunctional α‐mRNA of BW5147 origin

1989 • 188 citations

Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule.

1990 • 164 citations

Structural Basis of 2C TCR Allorecognition of H-2Ld Peptide Complexes

1998 • 160 citations

Lymphoid Cell Surface Interaction Structures Detected Using Cytolysis‐Inhibiting Monoclonal Antibodies

1982 • 155 citations

Control of MHC Restriction by TCR V _α CDR1 and CDR2

1996 • 152 citations

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways.

1989 • 151 citations

Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

2000 • 143 citations

CD3δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection

2000 • 137 citations

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.

1995 • 130 citations

Identification of a common docking topology with substantial variation among different TCR–peptide–MHC complexes

1998 • 116 citations

Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 β chain

1994 • 115 citations

CD4 Augments the Response of a T Cell to Agonist but Not to Antagonist Ligands

1997 • 114 citations

Positive Selection Through a Motif in the αβ T Cell Receptor

1998 • 111 citations

Requirement for CD8 β Chain in Positive Selection of CD8-Lineage T Cells

1994 • 110 citations

The thymus and central tolerance

2001 • 110 citations

Role of CD8β Domains in CD8 Coreceptor Function

2000 • 105 citations

A Motif within the T Cell Receptor α Chain Constant Region Connecting Peptide Domain Controls Antigen Responsiveness

1996 • 102 citations

The Efficiency of Antigen Recognition by CD8+ CTL Clones Is Determined by the Frequency of Serial TCR Engagement

1998 • 96 citations

Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells.

1992 • 93 citations

Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule

1995 • 89 citations

Co-engagement of CD8 with the T cell receptor is required for negative selection

1991 • 85 citations

CD8 Lineage Commitment in the Absence of CD8

1997 • 74 citations

T Cell Receptor (TCR) Antagonism without a Negative Signal: Evidence from T Cell Hybridomas Expressing Two Independent TCRs

1999 • 73 citations

CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

1993 • 71 citations

Positive selection of thymocytes: the long and winding road

1999 • 71 citations

A role for the cytoplasmic tail of the β chain of CD8 in thymic selection

1994 • 70 citations

Structural analysis of TCR-ligand interactions studied on H-2Kd-restricted cloned CTL specific for a photoreactive peptide derivative

1995 • 54 citations

The Thymus and Negative Selection

2000 • 46 citations

Peptide-Induced Positive Selection of TCR Transgenic Thymocytes in a Coreceptor-Independent Manner

1997 • 45 citations

Positive and Negative Selection of Thymocytes Depends on Lck Interaction with the CD4 and CD8 Coreceptors

2001 • 39 citations

Signals involved in thymocyte positive and negative selection

1999 • 39 citations

Photoaffinity labeling of the T cell receptor on cloned cytotoxic T lymphocytes by covalent photoreactive ligand.

1994 • 29 citations

An analysis of sequence variation in the β chain framework and complementarity determining regions of an allo-reactive T cell receptor

1994 • 23 citations

Defective Signaling to Fyn by a T Cell Antigen Receptor Lacking the α-Chain Connecting Peptide Motif

2001 • 16 citations

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