Circadian Regulator CLOCK Is a Histone Acetyltransferase

Coordination of circadian timing in mammals

2002 • 4,132 citations

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

2000 • 3,355 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Molecular Bases for Circadian Clocks

1999 • 2,823 citations

Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

2005 • 2,323 citations

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

2002 • 2,248 citations

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

1998 • 1,954 citations

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

1998 • 1,915 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Histone Acetyltransferases

2001 • 1,745 citations

Acetylation of Histones and Transcription-Related Factors

2000 • 1,702 citations

Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

1994 • 1,570 citations

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 • 1,567 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

Roles of histone acetyltransferases and deacetylases in gene regulation

1998 • 1,207 citations

Time zones: a comparative genetics of circadian clocks

2001 • 1,142 citations

ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION

1998 • 1,124 citations

Posttranslational Mechanisms Regulate the Mammalian Circadian Clock

2001 • 1,113 citations

Controlling the double helix

2003 • 1,102 citations

Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors

2001 • 1,013 citations

Signaling to Chromatin through Histone Modifications

2000 • 987 citations

MAMMALIAN CIRCADIAN BIOLOGY: Elucidating Genome-Wide Levels of Temporal Organization

2004 • 953 citations

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

2000 • 946 citations

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

1999 • 894 citations

Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim

1998 • 799 citations

Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus

2002 • 785 citations

The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

1998 • 761 citations

A Web of Circadian Pacemakers

2002 • 732 citations

A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless

1998 • 718 citations

The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

1996 • 705 citations

Rhythmic histone acetylation underlies transcription in the mammalian circadian clock

2002 • 665 citations

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

1997 • 664 citations

Binary switches and modification cassettes in histone biology and beyond

2003 • 628 citations

Histone acetylases and deacetylases in cell proliferation

1999 • 598 citations

Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions

2006 • 572 citations

Molecular Genetics of Circadian Rhythms in Mammals

2000 • 541 citations

Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity

2002 • 529 citations

Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing

2002 • 468 citations

Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature

2001 • 442 citations

Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin

2002 • 428 citations

NPAS2: A Gas-Responsive Transcription Factor

2002 • 422 citations

Metabolism and the Control of Circadian Rhythms

2002 • 390 citations

Circadian Programs of Transcriptional Activation, Signaling, and Protein Turnover Revealed by Microarray Analysis of Mammalian Cells

2002 • 328 citations

Circadian Clock Control by SUMOylation of BMAL1

2005 • 303 citations

A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

2005 • 293 citations

ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation

2000 • 271 citations

The acetyltransferase activity of CBP stimulates transcription

1998 • 265 citations

Light induces chromatin modification in cells of the mammalian circadian clock

2000 • 259 citations

Novel Substrate Specificity of the Histone Acetyltransferase Activity of HIV-1-Tat Interactive Protein Tip60

1997 • 234 citations

BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system

2003 • 230 citations

Multilevel regulation of the circadian clock

2000 • 219 citations

Histone Acetyltransferase-dependent Chromatin Remodeling and the Vascular Clock

2004 • 203 citations

Phenotypic Rescue of a Peripheral Clock Genetic Defect via SCN Hierarchical Dominance

2002 • 179 citations

Crystal Structure of Yeast Esa1 Suggests a Unified Mechanism for Catalysis and Substrate Binding by Histone Acetyltransferases

2000 • 155 citations

Cellular oscillators: rhythmic gene expression and metabolism

2005 • 139 citations

Chromatin: Histone acetyltransferases in control

1997 • 139 citations

Common pathways in circadian and cell cycle clocks: Light-dependent activation of Fos/AP-1 in zebrafish controls CRY-1a and WEE-1

2005 • 104 citations

Structural and functional features of transcription factors controlling the circadian clock

2005 • 101 citations

Light-induced phase-delay of the chicken pineal circadian clock is associated with the induction of cE4bp4 , a potential transcriptional repressor of cPer2 gene

2001 • 96 citations

Histone acetyltransferases: Preparation of substrates and assay procedures

1999 • 67 citations

Negative Control of Circadian Clock Regulator E4BP4 by Casein Kinase Iϵ-Mediated Phosphorylation

2004 • 40 citations

Analysis of Histone Phosphorylation: Coupling Intracellular Signaling to Chromatin Remodeling

2003 • 12 citations

An SDS-PAGE-Based Enzyme Activity Assay for the Detection and Identification of Histone Acetyltransferases

2003 • 9 citations