Caspases Cleave Focal Adhesion Kinase during Apoptosis to Generate a FRNK-like Polypeptide

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Caspases: killer proteases

1997 • 2,440 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors.

1995 • 619 citations

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

1994 • 525 citations

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase.

1994 • 516 citations

A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK

1996 • 488 citations

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

1996 • 371 citations

p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase

1996 • 364 citations

Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis

1997 • 338 citations

An SH3 Domain-Containing GTPase-Activating Protein for Rho and Cdc42 Associates with Focal Adhesion Kinase

1996 • 337 citations

Expression of focal adhesion kinase gene and invasive cancer

1993 • 335 citations

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.

1994 • 331 citations

Inhibition of Cell Spreading by Expression of the C-Terminal Domain of Focal Adhesion Kinase (FAK) Is Rescued by Coexpression of Src or Catalytically Inactive FAK: a Role for Paxillin Tyrosine Phosphorylation

1997 • 329 citations

Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells.

1996 • 265 citations

Caspase-mediated Cleavage of Focal Adhesion Kinase pp125FAK and Disassembly of Focal Adhesions in Human Endothelial Cell Apoptosis

1998 • 258 citations

Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase.

1995 • 229 citations

Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer

1996 • 201 citations

Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling.

1996 • 128 citations

Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors

1994 • 89 citations

Directional antisense and sense cDNA cloning using Epstein-Barr virus episomal expression vectors

1989 • 82 citations

pp125FAK in the Focal Adhesion

1996 • 62 citations