MPTP- and MPP+-induced effects on body temperature exhibit age- and strain-dependence in mice

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Multiple Range and Multiple F Tests

1955 • 22,685 citations

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I

1966 • 5,429 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

A new puffing pattern induced by temperature shock and DNP in drosophila

1962 • 1,969 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease

1992 • 1,201 citations

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1984 • 1,007 citations

Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice

1984 • 1,005 citations

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1991 • 554 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1992 • 457 citations

1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

1984 • 423 citations

Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria.

1986 • 404 citations

Neurochemical and Histochemical Characterization of Neurotoxic Effects of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine on Brain Catecholamine Neurones in the Mouse

1985 • 281 citations

The stress protein response in cultured neurons: Characterization and evidence for a protective role in excitotoxicity

1991 • 279 citations

Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse.

1994 • 254 citations

Rapid ATP Loss Caused by 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine in Mouse Brain

1991 • 242 citations

Intracranial microdialysis of salicylic acid to detect hydroxyl radical generation through dopamine autooxidation in the caudate nucleus: Effects of MPP+

1992 • 234 citations

The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum.

1992 • 231 citations

The influence of dose and dosing interval on MPTP-induced dopaminergic neurotoxicity in mice

1986 • 211 citations

Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice

1994 • 207 citations

Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism.

1993 • 177 citations

Differential Changes in Monoamine Oxidase A and B Activity in the Aging Rat Brain

1980 • 173 citations

Oxidative injury and the heat shock response

1990 • 172 citations

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) cause rapid ATP depletion in isolated hepatocytes

1986 • 167 citations

Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress.

1993 • 157 citations

New directions in the toxicokinetics of human lead exposure.

1993 • 155 citations

MPTP‐induced oxidative stress and neurotoxicity are age‐dependent: Evidence from measures of reactive oxygen species and striatal dopamine levels

1994 • 121 citations

MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes

1993 • 106 citations

Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity.

1987 • 105 citations

Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: A stereological estimate of neuronal loss

1993 • 103 citations

MPP+-induced neurotoxicity in mouse is age-dependent: evidenced by the selective inhibition of complexes of electron transport

1996 • 101 citations

The relationships between aging, monoamine oxidase, striatal dopamine and the effects of MPTP in C57BL/6 mice: a critical reassessment

1992 • 96 citations

Effects of 1‐Methyl‐4‐Phenyl‐ 1,2,3,6‐Tetrahydropyridine and 1 ‐Methyl‐4‐Phenylpyridinium Ion on ATP Levels of Mouse Brain Synaptosomes

1990 • 91 citations

Hsp70 mRNA induction is reduced in neurons of aged rat hippocampus after thermal stress

1992 • 76 citations

Do NMDA receptor antagonists protect against MPTP-toxicity? Biochemical and immunocytochemical analyses in black mice

1992 • 68 citations

Rise in heat‐shock protein level confers tolerance to energy deprivation

1993 • 63 citations

Entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into the rat brain.

1989 • 60 citations

2‐Deoxyglucose Enhances 1‐Methyl‐4‐Phenyl‐1, 2, 3, 6‐Tetrahydropyridine‐Induced ATP Loss in the Mouse Brain

1993 • 52 citations

Partial protective effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice

1992 • 44 citations

Depletion of cardiac norepinephrine in rats and mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1984 • 39 citations

Chronic alterations in jejunal myoelectric activity in rats due to MPTP

1987 • 36 citations

Early-stage loss of dopamine uptake-site binding in MPTP-treated monkeys.

1993 • 21 citations

Acute effects of 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) on catecholamines in heart, adrenal gland, retina and caudate nucleus of the cat

1988 • 19 citations

Acute effects of a parkinsonism-inducing neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mouse body temperature

1987 • 14 citations

Oral versus parenteral efficacy of 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP): Differential effects on depletion of heart norepinephrine and of striatal dopamine in mice

1987 • 13 citations

Studies on the neuromuscular blocking action of MPTP in the mouse phrenic nerve-diaphragm

1993 • 8 citations

Central hypothermic effects of some analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium ion (MPP+)

1987 • 4 citations