Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Cleavage of structural proteins during the assemble of the head of bacterio-phage T4

1970 • 5,738 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog

1987 • 1,004 citations

cdc25+ functions as an inducer in the mitotic control of fission yeast

1986 • 973 citations

Chapter 30 Cell Cycle Extracts

1991 • 953 citations

A family of human cdc2-related protein kinases.

1992 • 928 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2

1991 • 870 citations

Processing of Adenovirus 2-Induced Proteins

1973 • 762 citations

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B

1990 • 730 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Inactivation of the p34 ^cdc2 -Cyclin B Complex by the Human WEE1 Tyrosine Kinase

1992 • 688 citations

mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2

1991 • 688 citations

Creative blocks: cell-cycle checkpoints and feedback controls

1992 • 686 citations

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

1993 • 675 citations

Cyclin is a component of maturation-promoting factor from Xenopus

1990 • 674 citations

cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF

1989 • 666 citations

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

1992 • 638 citations

The cdc25 protein contains an intrinsic phosphatase activity

1991 • 595 citations

Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

1991 • 579 citations

Genetic control of cell division patterns in the Drosophila embryo

1989 • 567 citations

Characterization of the major protein-tyrosine-phosphatases of human placenta.

1988 • 554 citations

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins

1991 • 509 citations

The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

1991 • 504 citations

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

1991 • 502 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.

1993 • 475 citations

The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae

1991 • 463 citations

Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication

1990 • 460 citations

Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.

1992 • 459 citations

Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis

1989 • 438 citations

Regulation of the cdc25 protein during the cell cycle in Xenopus extracts

1992 • 430 citations

The roles of Drosophila cyclins A and B in mitotic control

1990 • 429 citations

A Tyr/Ser protein phosphatase encoded by vaccinia virus

1991 • 403 citations

Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus

1990 • 354 citations

Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase

1991 • 344 citations

p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast.

1991 • 342 citations

1002 Protein Phosphatases?

1992 • 330 citations

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

1991 • 318 citations

The Role of p34 Kinases in the G1 to S-Phase Transition

1992 • 313 citations

A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis

1991 • 310 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Oncogenes, Growth Factors, and Signal Transduction

1989 • 296 citations

Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity.

1992 • 294 citations

p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

1992 • 276 citations

Activation of the various cyclin/cdc2 protein kinases

1993 • 253 citations

The role of cyclin B in meiosis I.

1989 • 241 citations

Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules.

1988 • 234 citations

Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2

1992 • 231 citations

Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast

1990 • 221 citations

Cloning and sequencing of the cyclin-related Cdc13 + gene and a cytological study of its role in fission yeast mitosis

1988 • 220 citations

Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs.

1987 • 220 citations

Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner.

1991 • 218 citations

cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2.

1992 • 211 citations

Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.

1991 • 196 citations

Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits.

1992 • 191 citations

Control of programmed cyclin destruction in a cell-free system.

1989 • 138 citations

Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.

1992 • 134 citations

A post-ribosomal supernatant from activated Xenopus eggs that displays post-translationally regulated oscillation of its cdc2+ mitotic kinase activity.

1989 • 126 citations

Oscillation of MPF is accompanied by periodic association between cdc25 and cdc2-cyclin B

1992 • 119 citations

Conserved structural motifs in cyclins identified by sequence analysis

1991 • 110 citations

Cyclin A- and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts.

1992 • 91 citations

An extra copy of nimEcyclinB elevates pre-MPF levels and partially suppresses mutation of nimTcdc25 in Aspergillus nidulans.

1992 • 91 citations

Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2.

1992 • 75 citations

Cdc25 regulates the phosphorylation and activity of the Xenopus cdk2 protein kinase complex.

1992 • 63 citations

Control of the Cell Cycle in Early Embryos

1991 • 23 citations

Cloning and Characterization of Xenopus cdc2, a Component of MPF

1991 • 22 citations

Control of p34cdc2 Activation

1991 • 12 citations

A Consensus of Cyclin Sequences Reveals Homology with the ras Oncogene

1991 • 10 citations

Clues to the action of cdc25 protein

1991 • 5 citations

Higher eucaryotic cdc25 proteins are structurally related to phosphoseryl/threonyl protein phosphatases

1992 • 4 citations