Cell‐Mediated Immunity in Virus Infections of the Central Nervous System

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

1986 • 1,723 citations

Peptidergic neurones

1980 • 1,523 citations

ROLE OF ABERRANT HLA-DR EXPRESSION AND ANTIGEN PRESENTATION IN INDUCTION OF ENDOCRINE AUTOIMMUNITY

1983 • 1,275 citations

The somatic generation of immune recognition

1971 • 974 citations

Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis

1974 • 832 citations

MALARIAL DIABETES

1948 • 829 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

1982 • 754 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.

1985 • 526 citations

Pathogenesis of Infection with Human Immunodeficiency Virus

1987 • 496 citations

A BIOLOGICAL ROLE FOR THE MAJOR HISTOCOMPATIBILITY ANTIGENS

1975 • 488 citations

Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2

1987 • 429 citations

A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex product

1987 • 408 citations

Specificity of Virus‐Immune Effector T Cells for H‐2K or H‐2D Compatible Interactions: Implications for H‐Antigen Diversity

1976 • 385 citations

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

1987 • 367 citations

Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen

1987 • 348 citations

Multiple sclerosis and human T-cell lymphotropic retroviruses

1985 • 348 citations

Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells

1984 • 318 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo

1984 • 296 citations

Expression of T-cell antigen receptor genes during fetal development in the thymus

1985 • 293 citations

Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H‐2‐Restriction‐Specificity and in H‐2 Linked Ir Gene Control

1978 • 291 citations

Identity of cells that imprint H–2-restricted T-cell specificity in the thymus

1986 • 267 citations

Functional analysis of T lymphocyte subsets in antiviral host defense.

1987 • 237 citations

Immune Response(Ir)Genes of the Murine Major Histocompatibility Complex

1986 • 217 citations

Expression and function of CD4 in a murine T-cell hybridoma

1987 • 208 citations

Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TEMV-specific delayed-type hypersensitivity.

1985 • 207 citations

Domain interactions of H–2 class I antigens alter cytotoxic T-cell recognition sites

1984 • 207 citations

Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs.

1986 • 206 citations

Immune interferon release when a cloned cytotoxic T-cell line meets its correct influenza-infected target cell

1982 • 202 citations

Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells.

1987 • 194 citations

Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region.

1986 • 187 citations

Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response

1987 • 185 citations

Immunological Surveillance of Tumors in the Context of Major Histocompatibility Complex Restriction of T Cell Function

1984 • 185 citations

Interferon-γ induces the expression of H-2 and Ia antigens on brain cells

1984 • 182 citations

Transfection of the CD8 gene enhances T-cell recognition

1987 • 177 citations

The Human T Cell Receptor: Analysis with Cytotoxic T Cell Clones

1983 • 163 citations

Demyelination induced by Theiler's virus: influence of the H-2 haplotype.

1985 • 157 citations

The Effect of L3T4 T Cell Depletion on the Pathogenesis of Theiler's Murine Encephalomyelitis Virus Infection in CBA Mice

1987 • 155 citations

Molecular Genetics of the T Cell-Receptor Beta Chain

1985 • 140 citations

Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus

1986 • 138 citations

STUDIES OF THE ROLE OF THE THYMIC ENVIRONMENT IN THE INDUCTION OF TOLERANCE TO MHC ANTIGENS

1985 • 127 citations

The T cell repertoire may be biased in favor of MHC recognition

1986 • 121 citations

A speculative view of the multicomponent nature of T cell antigen recognition

1986 • 117 citations

Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c.

1987 • 104 citations

Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D.

1985 • 102 citations

Human disease: Mechanisms in multiple sclerosis

1985 • 100 citations

Immunocytochemical identification and quantitation of the mononuclear cells in the cerebrospinal fluid, meninges, and brain during acute viral meningoencephalitis.

1984 • 98 citations

Internalization of lymphocyte membrane components

1985 • 94 citations

Correlation of T cell receptor V beta gene family with MHC restriction.

1987 • 87 citations

The expression of MHC antigens on oligodendrocytes: Induction of polymorphic H-2 expression by lymphokines

1986 • 84 citations

Major histocompatibility complex class I molecules internalized via coated pits in T lymphocytes

1987 • 82 citations

Susceptibility to murine lymphocytic choriomeningitis maps to class I MHC genes—a model for MHC/disease associations

1985 • 78 citations

Phenotypic analysis of the inflammatory exudate in murine lymphocytic choriomeningitis.

1987 • 74 citations

Mutation in a new H-2-associated histocompatibility gene closely linked to H-2D.

1977 • 71 citations

T cell receptor variable gene usage in a specific cytotoxic T cell response. Primary structure of the antigen-MHC receptor of four hapten-specific cytotoxic T cell clones.

1987 • 68 citations

Virus-lymphocyte interaction: T cells of the helper subset are infected with lymphocytic choriomeningitis virus during persistent infection in vivo

1987 • 68 citations

Product of a transferred H–2Ld gene acts as restriction element for LCMV-specific killer T cells

1982 • 67 citations

Astrocytes as antigen-presenting cells. Part II: Unlike H-2K-dependent cytotoxic T cells, H-2Ia-restricted T cells are only stimulated in the presence of interferon-γ

1986 • 65 citations

Dissection of serological and cytolytic T lymphocyte epitopes on murine major histocompatibility antigens by a recombinant H-2 gene separating the first two external domains.

1984 • 62 citations

Expression of class II major histocompatibility antigens on reactive astrocytes and endothelial cells within the gliosis surrounding metastases and abscesses

1986 • 61 citations

Semliki Forest Virus-induced, Immune-mediated Demyelination: Adoptive Transfer Studies and Viral Persistence in Nude Mice

1987 • 60 citations

Nature of the Inflammatory Process in the Central Nervous System of Mice Infected with Lymphocytic Choriomeningitis Virus

1987 • 48 citations

The Theiler's murine encephalomyelitis virus (TMEV) model for multiple sclerosis shows a strong influence of the murine equivalents of HLA-A, B, and C

1987 • 47 citations

Immune T cells can protect or induce fatal neurological disease in murine lymphocytic choriomeningitis

1985 • 44 citations

Expression of Ia antigens on the surface of human oligodendrocytes and astrocytes in culture

1985 • 44 citations

Inducibility of Ia antigen on astrocytes by murine coronavirus JHM is rat strain dependent.

1987 • 42 citations

Consequences of a single Ir-gene defect for the pathogenesis of lymphocytic choriomeningitis

1985 • 41 citations

Brain Ia antigens have a bone marrow origin

1983 • 38 citations

Expression of Pgp‐1 (or Ly24) by subpopulations of mouse thymocytes and activated peripheral T lymphocytes

1987 • 38 citations

The acute inflammatory process in murine lymphocytic choriomeningitis is dependent on Lyt-2+ immune T cells

1987 • 37 citations

Analysis of Ia induction on Lewis rat astrocytes in vitro by virus particles and bacterial adjuvants

1987 • 37 citations

Japanese encephalitis: Idenufication of inflammatory cells in cerebrospinal fluid

1986 • 37 citations

T CELLS AND VIRAL INFECTIONS

1985 • 36 citations

Thymic T cells are driven to expand upon interaction with self-class II major histocompatibility complex gene products on accessory cells.

1984 • 33 citations

Cross‐reactive Cytotoxic T Cells to Alphavirus Infection

1979 • 33 citations

Clonal expansion and functional analysis of virus-specific T lymphocytes from cerebrospinal fluid in measles encephalitis

1983 • 32 citations

Characteristics of Poxvirus‐Induced Meningitis: Virus‐Specific and Non‐Specific Cytotoxic Effectors in the Inflammatory Exudate

1983 • 31 citations

Cells with natural killer activity in the cerebrospinal fluid of normal mice and athymic nude mice with acute Sindbis virus encephalitis.

1986 • 27 citations

Development and Loss of Virus‐Specific Thymic Competence in Bone Marrow Radiation Chimeras and Normal Mice

1981 • 27 citations

Natural Killer Cells Contribute to Inflammation but Do Not Appear to be Essential for the Induction of Clinical Lymphocytic Choriomeningitis

1986 • 25 citations

High‐Dose Survival in the Lymphocytic Choriomeningitis Virus Infection Is Accompanied by Suppressed DTH but Unaffected T‐Cell Cytotoxicity

1985 • 24 citations

A molecular hybrid of the H-2Dd and H-2Ld genes expressed in the dm1 mutant.

1984 • 21 citations

Analysis of T cell receptor-gene rearrangement in T cells from the cerebrospinal fluid of patients with multiple sclerosis

1987 • 21 citations

Role of the major histocompatibility complex in targeting effector T cells into a site of virus infection

1986 • 19 citations

Infection of Cultured Murine Brain Cells by Semliki Forest Virus: Effects of Interferon- beta on Viral Replication, Viral Antigen Display, Major Histocompatibility Complex Antigen Display and Lysis by Cytotoxic T Lymphocytes

1987 • 19 citations

Persistence of Inoue-Melnick virus and antibody in cerebrospinal fluid

1985 • 17 citations

Lymphohemopoietic origin of the immunogenic, virus-antigen-presenting cells triggering anti-viral T-cell responses

1980 • 17 citations

Differential effect of hybrid resistance on the localization of virus-immune effector T cells to spleen and brain

1986 • 9 citations

Virus-immune T cells and the major histocompatibility complex: Evolution of some basic concepts over the past two years

1986 • 5 citations