Examining Rhodopsin Folding and Assembly through Expression of Polypeptide Fragments

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis

1981 • 868 citations

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

1981 • 807 citations

Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin

1983 • 689 citations

Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.

1994 • 630 citations

Predicting the orientation of eukaryotic membrane-spanning proteins.

1989 • 596 citations

The structure of bovine rhodopsin

1983 • 513 citations

Constitutively active mutants of rhodopsin

1992 • 513 citations

Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa.

1991 • 492 citations

Transgenic mice with a rhodopsin mutation (Pro23His): A mouse model of autosomal dominant retinitis pigmentosa

1992 • 454 citations

Rhodopsin, photoreceptor of the rod cell. An emerging pattern for structure and function.

1992 • 439 citations

Rhodopsin and bacteriorhodopsin: structure—function relationships

1982 • 430 citations

A Null mutation in the rhodopsin gene causes rod photoreceptor dysfunction and autosomal recessive retinitis pigmentosa

1992 • 417 citations

Two adjacent cysteine residues in the C‐terminal cytoplasmic fragment of bovine rhodopsin are palmitylated

1988 • 409 citations

Monoclonal antibodies to rhodopsin: characterization, cross-reactivity, and application as structural probes

1983 • 392 citations

A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment

1994 • 338 citations

Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. Clustering of functional classes along the polypeptide chain.

1993 • 327 citations

Assembly of functional rhodopsin requires a disulfide bond between cysteine residues 110 and 187.

1990 • 320 citations

Structure and Function in Rhodopsin. 7. Point Mutations Associated with Autosomal Dominant Retinitis Pigmentosa

1994 • 309 citations

CONTROLLED PROTEOLYSIS OF NASCENT POLYPEPTIDES IN RAT LIVER CELL FRACTIONS

1970 • 301 citations

Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy

1995 • 278 citations

Predicting the topology of eukaryotic membrane proteins

1993 • 272 citations

A single amino acid substitution in rhodopsin (lysine 248—-leucine) prevents activation of transducin.

1988 • 260 citations

Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene.

1993 • 240 citations

Hepatic Golgi fractions resolved into membrane and content subfractions.

1982 • 235 citations

Anti-rhodopsin monoclonal antibodies of defined specificity: Characterization and application

1991 • 229 citations

Rhodopsin carbohydrate. Structure of small oligosaccharides attached at two sites near the NH2 terminus.

1979 • 223 citations

Structure and function in rhodopsin: the role of asparagine-linked glycosylation.

1994 • 215 citations

Bovine opsin has more than one signal sequence

1985 • 186 citations

Total synthesis of a gene for bovine rhodopsin.

1986 • 179 citations

In vivo expression of the lacY gene in two segments leads to functional lac permease.

1990 • 164 citations

Mapping Light-Dependent Structural Changes in the Cytoplasmic Loop Connecting Helixes C and D in Rhodopsin: A Site-Directed Spin Labeling Study

1995 • 160 citations

Plasma Membrane Localization and Functional Rescue of Truncated Forms of a G Protein-coupled Receptor

1995 • 158 citations

Site of attachment of 11-cis-retinal in bovine rhodopsin

1980 • 157 citations

Characterization of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Mutations on the cytoplasmic surface affect transducin activation

1993 • 142 citations

Identification of novel rhodopsin mutations responsible for retinitis pigmentosa: implications for the structure and function of rhodopsin.

1993 • 140 citations

Role of the intradiscal domain in rhodopsin assembly and function.

1990 • 139 citations

Retinal degeneration caused by dominant rhodopsin mutations in Drosophila

1995 • 135 citations

Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration.

1995 • 128 citations

Multiple topogenic sequences in bovine opsin.

1987 • 115 citations

A General Method for Mapping Tertiary Contacts between Amino Acid Residues in Membrane-Embedded Proteins

1995 • 103 citations

In vivo assembly of rhodopsin from expressed polypeptide fragments.

1995 • 103 citations

Light-stable rhodopsin. I. A rhodopsin analog reconstituted with a nonisomerizable 11-cis retinal derivative.

1992 • 91 citations

Structure and function in rhodopsin. Requirements of a specific structure for the intradiscal domain.

1994 • 80 citations

Reconstitution of an active lactose carrier in vivo by simultaneous synthesis of two complementary protein fragments

1990 • 75 citations

The orientation of the chromophore of vertebrate rhodopsin in the “meta” intermediate states and the reversibility of the meta II-meta III transition

1979 • 73 citations

Expression of Lactose Permease in Contiguous Fragments as a Probe for Membrane-Spanning Domains

1994 • 72 citations

Insertional mutagenesis as a probe of rhodopsin's topography, stability, and activity.

1994 • 69 citations

Structure and function in rhodopsin. Separation and characterization of the correctly folded and misfolded opsins produced on expression of an opsin mutant gene containing only the native intradiscal cysteine codons

1995 • 62 citations

Effects of Carboxy-Terminal Truncation on the Stability and G Protein-Coupling Activity of Bovine Rhodopsin

1994 • 56 citations

Molecular defects in Drosophila rhodopsin mutants

1989 • 46 citations

Complementation of Fragments of Triosephosphate Isomerase Defined by Exon Boundaries

1995 • 33 citations

The N-terminal residue of bovine rhodopsin is acetylmethionine

1980 • 22 citations