Cytokine-induced Apoptosis in Epithelial HT-29 Cells Is Independent of Nitric Oxide Formation

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

1993 • 1,084 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

A Fluorometric Assay for the Measurement of Nitrite in Biological Samples

1993 • 1,022 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Alzheimer's Disease--Genotypes, Phenotype, and Treatments

1997 • 884 citations

lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1993 • 877 citations

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

1997 • 809 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

The central executioners of apoptosis: caspases or mitochondria?

1998 • 772 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages.

1993 • 674 citations

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10.

1993 • 657 citations

Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease

1996 • 588 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1998 • 579 citations

Caspases and caspase inhibitors

1997 • 573 citations

Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function.

1993 • 565 citations

Nitric Oxide Protects Cultured Rat Hepatocytes from Tumor Necrosis Factor-α-induced Apoptosis by Inducing Heat Shock Protein 70 Expression

1997 • 527 citations

Nitric oxide and its role in apoptosis

1998 • 444 citations

IEX -1L, an Apoptosis Inhibitor Involved in NF-κB-Mediated Cell Survival

1998 • 417 citations

Nitric Oxide Synthase Induces Macrophage Death by Apoptosis

1993 • 361 citations

Nitric oxide induces apoptosis in mouse thymocytes.

1995 • 356 citations

Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease.

1996 • 349 citations

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

1995 • 343 citations

Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels.

1995 • 340 citations

Nitric Oxide Inhibits Fas-induced Apoptosis

1997 • 317 citations

APOPTOSIS OF CRYPT EPITHELIAL CELLS IN ULCERATIVE COLITIS

1996 • 299 citations

Interleukin 13 is a B cell stimulating factor.

1994 • 298 citations

Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene Expression

1997 • 276 citations

IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand

1993 • 260 citations

Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation

1997 • 252 citations

CD95 (APO-1/Fas)-mediated apoptosis in colon epithelial cells: A possible role in ulcerative colitis

1997 • 249 citations

Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-alpha and ligation of Fas antigen.

1995 • 248 citations

Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases.

1999 • 237 citations

Bcl-2 Protects Macrophages from Nitric Oxide-induced Apoptosis

1996 • 224 citations

An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors.

1993 • 219 citations

The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction

1994 • 207 citations

Interleukin-1β-Induced Nitric Oxide Production Activates Apoptosis in Pancreatic RINm5F Cells

1994 • 194 citations

Ceramide: an endogenous regulator of apoptosis and growth suppresion

1995 • 181 citations

Increased TNF-α-Induced Apoptosis in Lymphocytes from Aged Humans: Changes in TNF-α Receptor Expression and Activation of Caspases

1999 • 174 citations

Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.

1994 • 159 citations

The IL-13 receptor structure differs on various cell types and may share more than one component with IL-4 receptor.

1997 • 157 citations

IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway.

1996 • 148 citations

Expression of inducible nitric oxide synthase activity in human colon epithelial cells: modulation by T lymphocyte derived cytokines

1998 • 146 citations

CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.

1994 • 132 citations

Caspases Mediate Tumor Necrosis Factor-–Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production

1999 • 126 citations

Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B

1997 • 124 citations

Caspases Mediate Tumor Necrosis Factor-–Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production

1999 • 97 citations

Activation of Phosphatidylinositol 3-Kinase by Interleukin-13

1997 • 85 citations

Interleukin-13 in Combination With CD40 Ligand Potently Inhibits Apoptosis in Human B Lymphocytes: Upregulation of Bcl-xL and Mcl-1

1997 • 81 citations

Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT‐29

1995 • 80 citations

IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis.

1998 • 71 citations

IL-13 Suppresses TNF-Induced Activation of Nuclear Factor-κB, Activation Protein-1, and Apoptosis

1998 • 60 citations

Colitis and colonic mucosal barrier dysfunction.

1995 • 58 citations

C-X-C and C-C chemokine expression and secretion by the human colonic epithelial cell line, HT-29: differential effect of T lymphocyte-derived cytokines

1999 • 53 citations

IL‐13 and IL‐4 share signal transduction elements as well as receptor components in TF‐1 cells

1995 • 39 citations

Interleukin‐8 production by the human colon epithelial cell line HT‐29: modulation by interleukin‐13

1996 • 35 citations

Interferon-γ-Induced Differentiation and Apoptosis of HT29 Cells: Dissociation of (Glucosyl)ceramide Signaling

1998 • 12 citations