Radiation-induced adaptive response is not seen in cell lines showing a bystander effect but is seen in lines showing HRS/IRR response

International Journal of Radiation Biology

1959 • 1,730 citations

ACTION OF X-RAYS ON MAMMALIAN CELLS

1956 • 1,660 citations

Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know

2003 • 1,647 citations

Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine

1984 • 817 citations

Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells

1997 • 592 citations

Low-dose hypersensitivity: current status and possible mechanisms

2001 • 554 citations

Cell-Cell Contact during Gamma Irradiation Is Not Required to Induce a Bystander Effect in Normal Human Keratinocytes: Evidence for Release during Irradiation of a Signal Controlling Survival into the Medium

1998 • 423 citations

The adaptive response in radiobiology: evolving insights and implications.

1998 • 334 citations

The Response of Chinese Hamster V79 Cells to Low Radiation Doses: Evidence of Enhanced Sensitivity of the Whole Cell Population

1993 • 293 citations

Low-Dose Ionizing Radiation Decreases the Frequency of Neoplastic Transformation to a Level below the Spontaneous Rate in C3H 10T1/2 Cells

1996 • 287 citations

Human Lymphocytes Exposed to Low Doses of Ionizing Radiations Become Refractory to High Doses of Radiation as Well as to Chemical Mutagens that Induce Double-strand Breaks in DNA

1988 • 283 citations

Characterization of the Adaptive Response to Ionizing Radiation Induced by Low Doses of X Rays to Human Lymphocytes

1987 • 273 citations

Hypersensitivity to very-low single radiation doses: Its relationship to the adaptive response and induced radioresistance

1996 • 244 citations

Radiation-Induced Adaptive Response for Protection against Micronucleus Formation and Neoplastic Transformation in C3H 10T1/2 Mouse Embryo Cells

1994 • 216 citations

Low-Dose Hyper-radiosensitivity: A Consequence of Ineffective Cell Cycle Arrest of Radiation-Damaged G₂-Phase Cells

2004 • 215 citations

c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy.

1990 • 212 citations

Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells

2002 • 182 citations

Radioadaptive response revisited

2006 • 169 citations

The Shape of the Dose–Response Curve for Radiation-Induced Neoplastic TransformationIn Vitro: Evidence for an Adaptive Response against Neoplastic Transformation at Low Doses of Low-LET Radiation

2001 • 164 citations

Renal Damage in the Mouse: The Response to Very Small Doses per Fraction

1988 • 164 citations

A review of the bystander effect and its implications for low-dose exposure

2003 • 144 citations

Interrelationships amongst radiation-induced genomic instability, bystander effects, and the adaptive response

2004 • 140 citations

Relationship between Radiation-Induced Low-Dose Hypersensitivity and the Bystander Effect

2002 • 139 citations

A Dose Threshold for a Medium Transfer Bystander Effect for a Human Skin Cell Line

2006 • 138 citations

Alpha-Particle-Induced Increases in the Radioresistance of Normal Human Bystander Cells

2002 • 132 citations

Cellular radiation effects and the bystander response

2006 • 130 citations

The British Journal of Cancer

1985 • 122 citations

Bystander and Delayed Effects after Fractionated Radiation Exposure

2002 • 118 citations

Adaptive Responses to Low-Dose/Low-Dose-Rate γ Rays in Normal Human Fibroblasts: The Role of Growth Architecture and Oxidative Metabolism

2006 • 107 citations

An Association between the Radiation-Induced Arrest of G₂-Phase Cells and Low-Dose Hyper-Radiosensitivity: A Plausible Underlying Mechanism?

2003 • 106 citations

The Use of ‘Top-up’ Experiments to Investigate the Effect of Very Small Doses Per Fraction in Mouse Skin

1985 • 99 citations

Medium from Irradiated Cells Induces Dose-Dependent Mitochondrial Changes and BCL2 Responses in Unirradiated Human Keratinocytes

2005 • 97 citations

Bystander Effects in Repair-Deficient Cell Lines

2004 • 94 citations

The Elimination of Low-Dose Hypersensitivity in Chinese Hamster V79-379A Cells by Pretreatment with X Rays or Hydrogen Peroxide

1995 • 92 citations

Radiation-induced bystander effects and adaptive responses—the Yin and Yang of low dose radiobiology?

2004 • 88 citations

Interaction between Radiation-Induced Adaptive Response and Bystander Mutagenesis in Mammalian Cells

2003 • 85 citations

Radiation-Induced Adaptive Responses and Bystander Effects

2004 • 80 citations

Low-Dose Hyper-radiosensitivity is not Caused by a Failure to Recognize DNA Double-Strand Breaks

2006 • 76 citations

Adaptive response and its variation in human normal and tumour cells

1999 • 74 citations

Increased sensitivity of human keratinocytes immortalized by human papillomavirus type 16 DNA to growth control by retinoids.

1992 • 72 citations

DNA Damage Responses at Low Radiation Doses

2005 • 64 citations

RADIATION BIOLOGY: CONCEPTS FOR RADIATION PROTECTION

2004 • 59 citations

Apoptosis and the adaptive response in human lymphocytes

1999 • 53 citations

Multiphasic Survival Curves for Cells of Human Tumor Cell Lines: Induced Repair or Hypersensitive Subpopulation?

1994 • 51 citations

A biological-based model that links genomic instability, bystander effects, and adaptive response

2004 • 48 citations

RADIATION BIOLOGY: CONCEPTS FOR RADIATION PROTECTION

2005 • 47 citations

Cytogenetic dose–response and adaptive response in cells of ungulate species exposed to ionizing radiation

2004 • 43 citations

The LNT model is the best we can do—today

2003 • 35 citations

The linear quadratic fit for lung function after irradiation with X-rays at smaller doses per fraction than 2 Gy.

1986 • 32 citations

Cytogenetic Adaptive Response of Cultured Fish Cells to Low Doses of X-rays.

1992 • 32 citations

Adaptive responses in human glioma cells assessed by clonogenic survival and DNA strand break analysis

2003 • 21 citations

Cellular response to low-dose irradiation

1998 • 20 citations