Interrelationships amongst radiation-induced genomic instability, bystander effects, and the adaptive response

Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know

2003 • 1,647 citations

Actions of Radiations on Living Cells

1955 • 1,242 citations

Multiple mutations and cancer

2003 • 748 citations

The radiobiology of cultured mammalian cells

1967 • 687 citations

Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: I. Radiation-Induced Genomic Instability and Bystander EffectsIn Vitro

2003 • 647 citations

Transmission of chromosomal instability after plutonium α-particle irradiation

1992 • 603 citations

Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells

2001 • 586 citations

Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: II. Radiation-Induced Genomic Instability and Bystander EffectsIn Vivo,Clastogenic Factors and Transgenerational Effects

2003 • 535 citations

Intercellular Communication Is Involved in the Bystander Regulation of Gene Expression in Human Cells Exposed to Very Low Fluences of Alpha Particles

1998 • 509 citations

Radiation-induced bystander effects — implications for cancer

2004 • 462 citations

Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells.

1997 • 445 citations

Cell-Cell Contact during Gamma Irradiation Is Not Required to Induce a Bystander Effect in Normal Human Keratinocytes: Evidence for Release during Irradiation of a Signal Controlling Survival into the Medium

1998 • 423 citations

Studies of bystander effects in human fibroblasts using a charged particle microbeam

1998 • 410 citations

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

1999 • 397 citations

Linking the epigenetic ‘language’ of covalent histone modifications to cancer

2004 • 385 citations

Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?

2001 • 371 citations

ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

2002 • 356 citations

The adaptive response in radiobiology: evolving insights and implications.

1998 • 334 citations

Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures.

2002 • 325 citations

Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis

1994 • 321 citations

The Bystander Effect in Radiation Oncogenesis: I. Transformation in C3H 10T½ CellsIn Vitrocan be Initiated in the Unirradiated Neighbors of Irradiated Cells

2001 • 308 citations

STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells

2004 • 305 citations

Chromosomal instability in the descendants of unirradiated surviving cells after α-particle irradiation

1998 • 303 citations

Delayed Chromosomal Instability Induced by DNA Damage

1993 • 276 citations

Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells.

1997 • 264 citations

Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures

1996 • 263 citations

Hypersensitivity to very-low single radiation doses: Its relationship to the adaptive response and induced radioresistance

1996 • 244 citations

Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells.

2003 • 238 citations

Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation

2003 • 229 citations

Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts

2001 • 222 citations

Chromosomal instability in unirradiated cells induced in vivo by a bystander effect of ionizing radiation.

2000 • 211 citations

Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation?

2003 • 209 citations

Delayed chromosomal instability induced by DNA damage.

1993 • 208 citations

Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review

2003 • 203 citations

α-particle-induced chromosomal instability in human bone marrow cells

1994 • 200 citations

Radiation-Induced Chromosomal Instability in BALB/c and C57BL/6 Mice: The Difference Is as Clear as Black and White

1997 • 193 citations

Actions of Radiations on Living Cells

1955 • 187 citations

Persistent oxidative stress in chromosomally unstable cells.

2003 • 171 citations

Partial volume rat lung irradiation: An evaluation of early DNA damage

1998 • 164 citations

The Shape of the Dose–Response Curve for Radiation-Induced Neoplastic TransformationIn Vitro: Evidence for an Adaptive Response against Neoplastic Transformation at Low Doses of Low-LET Radiation

2001 • 164 citations

Increased Chromosome Aberration Levels in Cells from Mouse Fetuses after Zygote X-irradiation

1989 • 162 citations

Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype

1992 • 161 citations

Chromosome Damage Induced by Plasma of X-Rayed Patients: An Indirect Effect of X-Ray

1968 • 152 citations

Relationship between Radiation-Induced Low-Dose Hypersensitivity and the Bystander Effect

2002 • 139 citations

Clonal chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures

1993 • 138 citations

HPRTMutants Induced in Bystander Cells by Very Low Fluences of Alpha Particles Result Primarily from Point Mutations

2001 • 133 citations

A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse.

2000 • 132 citations

Physical and Biological Interface Dose Effects in Tissue due to X-Ray-Induced Release of Secondary Radiation from Metallic Gold Surfaces

1998 • 130 citations

Bystander Effects: Intercellular Transmission of Radiation Damage Signals

2002 • 130 citations

Genetic factors influencing alpha-particle-induced chromosomal instability

1997 • 128 citations

Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect.

2003 • 119 citations

Bystander and Delayed Effects after Fractionated Radiation Exposure

2002 • 118 citations

Clonal Analysis of Delayed Karyotypic Abnormalities and Gene Mutations in Radiation-Induced Genetic Instability

1996 • 114 citations

True

2000 • 109 citations

Effects of Ionizing Radiation in Targeted and Nontargeted Cells

2000 • 108 citations

Early Events in the Apoptotic Cascade Initiated in Cells Treated with Medium from the Progeny of Irradiated Cells

2002 • 106 citations

Specific chromosome instability induced by heavy ions: a step towards transformation of human fibroblasts?

1993 • 105 citations

Induction of Chromosomal Instability by Chronic Oxidative Stress

2003 • 104 citations

Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells

1990 • 101 citations

Monitoring and Signaling of Radiation-Induced Damage in Mammalian Cells

1998 • 100 citations

Delayed replication timing leads to delayed mitotic chromosome condensation and chromosomal instability of chromosome translocations

2001 • 97 citations

Expression of Lethal Mutations in Progeny of Irradiated Mammalian Cells

1989 • 96 citations

Dose Responses for Adaption to Low Doses of⁶⁰Co γ Rays and³H β Particles in Normal Human Fibroblasts

2002 • 95 citations

Contribution of antioxidant enzymes to the adaptive response to ionizing radiation of human lymphoblasts

1999 • 94 citations

Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation

2001 • 93 citations

In vivo chromosomal instability and transmissible aberrations in the progeny of haemopoietic stem cells induced by high- and low-LET radiations

2001 • 93 citations

Dysfunctional mammalian telomeres join with DNA double-strand breaks

2004 • 86 citations

Interaction between Radiation-Induced Adaptive Response and Bystander Mutagenesis in Mammalian Cells

2003 • 85 citations

The kinase activity of DNA-PK is required to protect mammalian telomeres

2003 • 82 citations

Oxidative stress in cells exposed to low levels of ionizing radiation

2001 • 78 citations

Adaptive response studies may help choose astronauts for long-term space travel

2003 • 74 citations

Long-Term Genomic Instability in Human Lymphocytes Induced by Single-Particle Irradiation

2001 • 74 citations

Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review

2003 • 70 citations

A low, adaptive dose of gamma-rays reduced the number and altered the spectrum of S1− mutants in human-hamster hybrid AL cells

1996 • 69 citations

Induction of Chromosomal Instability in Human Mammary Cells by Neutrons and Gamma Rays

1997 • 64 citations

Delayed Chromosomal Instability in Human T-lymphocyte Clones Exposed to Ionizing Radiation

1995 • 63 citations

Risk Factors for Severe Radiation Pneumonitis in Lung Cancer

1999 • 58 citations

Delayed appearance of radiation-induced mutations at the Hprt locus in murine hemopoietic cells.

1997 • 53 citations

Radioresponsiveness at low doses: hyper-radiosensitivity and increased radioresistance in mammalian cells

1999 • 53 citations

DNA methylation and chromosome instability in lymphoblastoid cell lines

2000 • 52 citations

Mechanistic Basis for Nonlinear Dose-Response Relationships for Low-Dose Radiation-Induced Stochastic Effects

2003 • 50 citations

Chromosomal radiosensitivity study of temporary nuclear workers and the support of the adaptive response induced by occupational exposure

2002 • 47 citations

Radiation-induced mutations in unirradiated DNA

1999 • 44 citations

Persistent expression of morphological abnormalities in the distant progeny of irradiated cells

1996 • 43 citations

Radiation-induced chromosomal instability in human mammary epithelial cells

1996 • 37 citations

The rise and fall of genomic methylation in cancer

2003 • 36 citations

Adaptive response induction and variation in human lymphoblastoid cell lines

2002 • 30 citations

Investigating the cellular effects of isolated radiation tracks using microbeam techniques

2002 • 29 citations

DNA and telomeres: beginnings and endings

2004 • 29 citations

Radiation-induced genomic instability in immortalized haemopoietic stem cells

2003 • 28 citations

Mechanisms of cell death associated with death-inducing factors from genomically unstable cell lines

2003 • 28 citations

Adaptive responses in human glioma cells assessed by clonogenic survival and DNA strand break analysis

2003 • 21 citations

Targeted breakage of paracentromeric heterochromatin induces chromosomal instability

1998 • 16 citations

Radiation-induced genomic instability in immortalized haemopoietic stem cells

2003 • 11 citations

In vivo effect of gamma ray pretreatment on sister-chromatid exchange induction by mitomycin C in murine bone marrow cells

1996 • 9 citations