Radiation-induced bystander effects and adaptive responses—the Yin and Yang of low dose radiobiology?

Induction of sister chromatid exchanges by extremely low doses of alpha-particles.

1992 • 979 citations

Singlet oxygen-mediated damage to proteins and its consequences

2003 • 938 citations

Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: I. Radiation-Induced Genomic Instability and Bystander EffectsIn Vitro

2003 • 647 citations

Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells

1997 • 592 citations

MAPK pathways in radiation responses

2003 • 589 citations

Radiation-induced bystander effects — implications for cancer

2004 • 462 citations

Cell-Cell Contact during Gamma Irradiation Is Not Required to Induce a Bystander Effect in Normal Human Keratinocytes: Evidence for Release during Irradiation of a Signal Controlling Survival into the Medium

1998 • 423 citations

The Frequency of U-Shaped Dose Responses in the Toxicological Literature

2001 • 419 citations

Hormesis: U-shaped dose responses and their centrality in toxicology

2001 • 411 citations

Studies of bystander effects in human fibroblasts using a charged particle microbeam

1998 • 410 citations

Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?

2001 • 371 citations

Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures.

2002 • 325 citations

Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect

2003 • 315 citations

Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis

2000 • 262 citations

Relative Contribution of Bystander and Targeted Cell Killing to the Low-Dose Region of the Radiation Dose–Response Curve

2000 • 256 citations

Extracellular Signaling through the Microenvironment: A Hypothesis Relating Carcinogenesis, Bystander Effects, and Genomic Instability

2001 • 252 citations

Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation

2003 • 229 citations

Initiation of Apoptosis in Cells Exposed to Medium from the Progeny of Irradiated Cells: A Possible Mechanism for Bystander-Induced Genomic Instability?

2002 • 226 citations

Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review

2003 • 203 citations

Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells

2002 • 182 citations

Applications of hormesis in toxicology, risk assessment and chemotherapeutics

2002 • 155 citations

Free Radical-Initiated and Gap Junction-Mediated Bystander Effect due to Nonuniform Distribution of Incorporated Radioactivity in a Three-Dimensional Tissue Culture Model

2001 • 153 citations

Individual variation in the production of a `bystander signal' following irradiation of primary cultures of normal human urothelium

2001 • 144 citations

A review of the bystander effect and its implications for low-dose exposure

2003 • 144 citations

Bystander effect induced by counted high‐LET particles in confluent human fibroblasts: a mechanistic study

2003 • 142 citations

Heavy metals of relevance to human health induce genomic instability

2001 • 140 citations

Relationship between Radiation-Induced Low-Dose Hypersensitivity and the Bystander Effect

2002 • 139 citations

Alpha-Particle-Induced Increases in the Radioresistance of Normal Human Bystander Cells

2002 • 132 citations

Bystander Effects: Intercellular Transmission of Radiation Damage Signals

2002 • 130 citations

Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer

2000 • 126 citations

Bystander-induced Apoptosis and Premature Differentiation in Primary Urothelial Explants after Charged Particle Microbeam Irradiation

2002 • 125 citations

Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect.

2003 • 119 citations

Bystander and Delayed Effects after Fractionated Radiation Exposure

2002 • 118 citations

Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells

2003 • 110 citations

A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation

2003 • 109 citations

True

2000 • 109 citations

Early Events in the Apoptotic Cascade Initiated in Cells Treated with Medium from the Progeny of Irradiated Cells

2002 • 106 citations

Induction of Chromosomal Instability by Chronic Oxidative Stress

2003 • 104 citations

Bystander Effects in Repair-Deficient Cell Lines

2004 • 94 citations

Exposure to low-level chemicals and ionizing radiation: reactive oxygen species and cellular pathways

2002 • 89 citations

Interaction between Radiation-Induced Adaptive Response and Bystander Mutagenesis in Mammalian Cells

2003 • 85 citations

Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents.

1998 • 82 citations

Non-targeted Effects of Radiation: Bystander Responses in Cell and Tissue Models

2002 • 81 citations

The Radiation-Induced Bystander Effect for Clonogenic Survival

2002 • 79 citations

Radiation-induced clastogenic plasma factors

1984 • 74 citations

Oxidative stress-related clastogenic factors in plasma from Chernobyl liquidators: protective effects of antioxidant plant phenols, vitamins and oligoelements

1997 • 71 citations

Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review

2003 • 70 citations

Cell proximity is a prerequisite for the proliferative response of bystander cells co‐cultured with cells irradiated with γ‐rays

2003 • 69 citations

Expression of delayed toxicity and lethal mutations in the progeny of human cells surviving exposure to radiation and other environmental mutagens

1998 • 68 citations

Tissue‐specific p53 responses to ionizing radiation and their genetic modification: the key to tissue‐specific tumour susceptibility?

2003 • 65 citations

Survival of human epithelial cells irradiated with cobalt 60 as microcolonies or single cells

1997 • 58 citations

Genotoxic Damage in Non-irradiated Cells: Contribution from the Bystander Effect

2002 • 57 citations

Monoamine oxidase inhibitors l-deprenyl and clorgyline protect nonmalignant human cells from ionising radiation and chemotherapy toxicity

2003 • 53 citations

The not-so innocent bystander: the microenvironment as a therapeutic target in cancer

2003 • 49 citations

Radiation-Induced Bystander Effects

2003 • 48 citations

Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells

2003 • 44 citations

Clustering of apoptotic cells via bystander killing by peroxides

2000 • 37 citations

Investigating the nature of chromatid breaks produced by restriction endonucleases

1997 • 31 citations

Novel Approaches with Track Segment Alpha Particles and Cell Co-cultures in Studies of Bystander Effects

2002 • 28 citations

Coordinate late expression of trefoil peptide genes (pS2/TFF1 and ITF/TFF3) in human breast, colon, and gastric tumor cells exposed to X-rays.

2002 • 27 citations

Expression of Lethal Mutations Is Suppressed in Neoplastically Transformed Cells and after Treatment of Normal Cells with Carcinogens

1996 • 23 citations

Recovery of the radiation survival-curve shoulder in CHO-KI, XRS-5 and revertant XRS-5 populations

1993 • 20 citations

[The redox homeostasis system in radiation-induced genomic instability].

2001 • 14 citations

Guest Editors

2003 • 11 citations