Basic mechanisms in heart failure: The cytokine hypothesis

Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure

1991 • 8,296 citations

Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions

1992 • 3,708 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Regular physical exercise and low-fat diet. Effects on progression of coronary artery disease.

1992 • 1,349 citations

Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)

1996 • 1,203 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart

1996 • 993 citations

NHLBI funding policies. Enhancing stability, predictability, and cost control.

1994 • 765 citations

Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.

1993 • 708 citations

Endothelin in human congestive heart failure.

1994 • 598 citations

Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure

1995 • 575 citations

Tumor Necrosis Factor Soluble Receptors in Patients With Various Degrees of Congestive Heart Failure

1995 • 534 citations

Increased circulating cytokines in patients with myocarditis and cardiomyopathy.

1994 • 525 citations

Basic Mechanisms in Congestive Heart Failure

1994 • 365 citations

Prognostic importance of atrial natriuretic peptide in patients with chronic heart failure

1989 • 354 citations

Increased concentrations of tumour necrosis factor in "cachectic" patients with severe chronic heart failure.

1991 • 348 citations

Expression and Functional Significance of Tumor Necrosis Factor Receptors in Human Myocardium

1995 • 348 citations

Structural remodeling in hypertensive heart disease and the role of hormones.

1994 • 237 citations

Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure. Relation to nitric oxide-dependent vasodilation in the forearm circulation.

1994 • 219 citations

TUMOUR NECROSIS FACTOR IN BRONCHOPULMONARY SECRETIONS OF PATIENTS WITH ADULT RESPIRATORY DISTRESS SYNDROME

1989 • 202 citations

Lymphocytic myocarditis presenting as unexplained ventricular arrhythmias: Diagnosis with endomyocardial biopsy and response to immunosuppression

1984 • 172 citations

Tumour necrosis factor alpha in severe congestive cardiac failure.

1993 • 172 citations

Relation between endothelin-1 spillover in the lungs and pulmonary vascular resistance in patients with chronic heart failure

1994 • 168 citations

Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway.

1990 • 165 citations

Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure.

1994 • 156 citations

Formation of Ion-Permeable Channels by Tumor Necrosis Factor-α

1992 • 143 citations

Plasma big endothelin-1 concentrations in congestive heart failure patients with or without systemic hypertension

1993 • 127 citations

Increased levels of serum neoprotein and decreased production of neutrophil superoxide anions in chronic heart failure with elevated levels of tumor necrosis factor-alpha

1993 • 90 citations

Tumor necrosis factor-α and the failing human heart-TNFα and heart failure

1995 • 60 citations

Endothelin stimulates multiple responses in isolated adult ventricular cardiac myocytes

1992 • 43 citations

Influence of Congestive Heart Failure on Endothelin Levels and Receptors in Rabbits

1993 • 42 citations

Role of endothelin in heart function in health and disease.

1993 • 28 citations

Endothelin in cardiopulmonary disease: factor paracrine vs neurohumoral.

1993 • 23 citations

Tumor necrosis factor alpha and cardiac remodeling

1995 • 11 citations