Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Cloning and expression of cDNA for a human thromboxane A2 receptor

1991 • 680 citations

[The role of protein kinase C in cell surface signal transduction and tumor promotion].

1986 • 508 citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

1991 • 373 citations

Determination of ATP and ADP in blood platelets: A modification of the firefly luciferase assay for plasma

1972 • 330 citations

Measurement of ionized calcium in blood platelets with the photoprotein aequorin. Comparison with Quin 2.

1985 • 227 citations

Inositol 1,4,5-triphosphate-induced granule secretion in platelets. Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein-dependent mechanism distinct from that of thrombin.

1987 • 156 citations

Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets

1989 • 154 citations

The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems.

1990 • 141 citations

Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni

1986 • 132 citations

Characterization of [5,6-3H]SQ 29,548 as a high affinity radioligand, binding to thromboxane A2/prostaglandin H2-receptors in human platelets.

1988 • 87 citations

Regulation of thromboxane receptor activation in human platelets.

1989 • 81 citations

Inositol triphosphate-induced Ca2+ release from human platelet membranes

1985 • 71 citations

In vitro and in vivo effects of new powerful thromboxane antagonists (3-alkylamino pinane derivatives).

1983 • 59 citations

Stimulations of arachidonate release and inositol-1,4,5-triphosphate formation are mediated by distinct G-proteins in human platelets

1987 • 52 citations

Abnormal platelet response to thromboxane A2.

1981 • 50 citations

Elevation of cytoplasmic free calcium concentration by stable thromboxane A2 analogue in human platelets

1983 • 49 citations

Hemorrhagic Thrombocytopathy with Platelet Thromboxane A2 Receptor Abnormality: Defective Signal Transduction with Normal Binding Activity

1987 • 41 citations

A new congenital defect of platelet secretion: impaired responsiveness of the platelets to cytoplasmic free calcium

1983 • 37 citations

Receptors and Phosphoinositide-Generated Second Messengers

1985 • 24 citations

A new familial defect of platelet release mechanism (the intracellular Ca++ transport defect?).

1981 • 18 citations

Role of protein kinase C in U46619-induced platelet shape change, aggregation and secretion

1989 • 16 citations

Defective platelet aggregation to the calcium ionophore A23187 in a patient with a lifelong bleeding disorder.

1983 • 16 citations

Interrelationship between secretion, protein phosphorylation and intracellular Ca2+ concentration in platelets stimulated by thrombin or thromboxane A2 analogue

1986 • 14 citations

Interrelations ofPlatelet Aggregation andSecretion

1977 • 6 citations

Characterization of platelet cytoplasmic Ca2+ mobilization in patients with congenital cyclo-oxygenase deficiency and with defective platelet aggregation to A23187.

1989 • 4 citations

Impaired platelet response to thromboxane-A2 and defective calcium mobilization in a patient with a bleeding disorder

1981 • 4 citations