Treatment of Experimental (Trinitrobenzene Sulfonic Acid) Colitis by Intranasal Administration of Transforming Growth Factor (Tgf)-β1 Plasmid

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Inflammatory bowel disease: Etiology and pathogenesis

1998 • 2,095 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

1995 • 1,338 citations

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1999 • 1,325 citations

Inflammatory Bowel Disease

1991 • 1,264 citations

Experimental models of inflammatory bowel disease

1995 • 1,215 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

The cell biology of transforming growth factor β

1990 • 537 citations

Oxazolone Colitis: A Murine Model of T Helper Cell Type 2 Colitis Treatable with Antibodies to Interleukin 4

1998 • 523 citations

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.

1996 • 487 citations

An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease

1998 • 479 citations

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

1993 • 471 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease.

1996 • 423 citations

Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice

1997 • 422 citations

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

1997 • 399 citations

Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis.

1993 • 386 citations

The Activation Sequence of Thrombospondin-1 Interacts with the Latency-associated Peptide to Regulate Activation of Latent Transforming Growth Factor-β

1999 • 336 citations

T Cell–mediated Pathology in Two Models of Experimental Colitis Depends Predominantly on the Interleukin 12/Signal Transducer and Activator of Transcription (Stat)-4 Pathway, but Is Not Conditional on Interferon γ Expression by T Cells

1998 • 288 citations

Regulatory T cells and inflammatory bowel disease

1999 • 270 citations

Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay.

1990 • 247 citations

Intranasally Induced Immunological Tolerance Is Determined by Characteristics of the Draining Lymph Nodes: Studies with OVA and Human Cartilage gp-39

1999 • 179 citations

Hapten-induced Colitis Is Associated with Colonic Patch Hypertrophy and T Helper Cell 2–Type Responses

1999 • 177 citations

TGF-beta enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice.

1995 • 170 citations

The Pathogenesis of Mucosal Inflammation in Murine Models of Inflammatory Bowel Disease and Crohn Disease

1998 • 165 citations

IL-10-mediated suppression of TNF-α production is independent of its ability to inhibit NFκB activity

1998 • 160 citations

Colitis in transgenic and knockout animals as models of human inflammatory bowel disease

1999 • 151 citations

Plasmid DNA encoding transforming growth factor-beta1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model.

1998 • 134 citations

Nonlymphocyte-Derived Tumor Necrosis Factor Is Required for Induction of Colitis in Recombination Activating Gene (Rag)2−/− Mice upon Transfer of Cd4+Cd45rbhi T Cells

1999 • 124 citations

Autocrine induction of tumor protease production and invasion by a metallothionein-regulated TGF-beta 1 (Ser223, 225).

1992 • 121 citations

Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease.

1997 • 116 citations

Improved procedure for the isolation of functionally active lymphoid cells from the murine intestine

1987 • 113 citations

Histochemical Staining Following LacZ Gene Transfer Underestimates Transfection Efficiency

1997 • 91 citations

T Helper Type 2 Cell Differentiation Occurs in the Presence of Interleukin 12 Receptor β2 Chain Expression and Signaling

2000 • 63 citations

Distribution Fate and Mechanism of Immune Modulation Following Mucosal Delivery of Plasmid DNA Encoding IL-10

1999 • 54 citations

Transforming growth factor-beta gene therapy ameliorates experimental colitis in rats.

1995 • 46 citations

Differential regulation of C alpha 1 and C alpha 2 germ-line and mature mRNA transcripts in human peripheral blood B cells.

1994 • 40 citations

Immunomodulation by mucosal gene transfer using TGF-beta DNA.

1998 • 37 citations

Improved Detection Reliability of β-Galactosidase in Histological Preparations

1999 • 12 citations