Direct nonradioactive in situ hybridization of somatic cell hybrid DNA to human lymphocyte chromosomes

Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization.

1986 • 3,231 citations

A simple method of reducing the fading of immunofluorescence during microscopy

1981 • 1,907 citations

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

1988 • 1,334 citations

Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries

1988 • 1,171 citations

Enzymatic synthesis of biotin-labeled polynucleotides: novel nucleic acid affinity probes.

1981 • 1,165 citations

Reverse fluorescent chromosome banding with chromomycin and DAPI

1976 • 958 citations

Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes

1988 • 563 citations

Sensitive, high-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated copies of EBV in a lymphoma line

1988 • 550 citations

In situ hybridization as a tool to study numerical chromosome aberrations in solid bladder tumors

1988 • 462 citations

Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84

1986 • 380 citations

Isolation and characterization of a major tandem repeat family from the human X chromosome

1983 • 258 citations

Rapid detection of human chromosome 21 aberrations by in situ hybridization.

1988 • 251 citations

Staining of Some Specific Regions of Human Chromosomes, particularly the Secondary Constriction of No. 9

1972 • 251 citations

Transfer of Genetic Information by Purified Metaphase Chromosomes

1973 • 236 citations

Detection of chromosome aneuploidy in interphase nuclei from human primary breast tumors using chromosome-specific repetitive DNA probes.

1988 • 231 citations

Use of whole cosmid cloned genomic sequences for chromosomal localization by non-radioactive in situ hybridization

1987 • 220 citations

Three‐color fluorescence in situ hybridization for the simultaneous detection of multiple nucleic acid sequences

1989 • 219 citations

Isolation of probes detecting restriction fragment length polymorphisms from X chromosome-specific libraries: potential use for diagnosis of Duchenne muscular dystrophy

1985 • 217 citations

Rapid interphase and metaphase assessment of specific chromosomal changes in neuroectodermal tumor cells by in situ hybridization with chemically modified DNA probes

1988 • 177 citations

Transfer of the human gene for hypoxanthine-guanine phosphoribosyltransferase via isolated human metaphase chromosomes into mouse L-cells.

1975 • 120 citations

A deletion hot spot in the Duchenne muscular dystrophy gene

1988 • 114 citations

Segregation of the Huntington disease region of human chromosome 4 in a somatic cell hybrid

1989 • 100 citations

Differential staining of interspecific chromosomes in somatic cell hybrids by alkaline Giemsa stain

1976 • 98 citations

Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids.

1986 • 82 citations

A mouse-human hybrid cell panel for mapping human chromosome 16.

1986 • 67 citations

A somatic cell hybrid panel for localizing DNA segments near the Huntington's disease gene

1987 • 64 citations

Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization

1986 • 63 citations

Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells

1989 • 57 citations

Construction of fifteen human chromosome-specific DNA libraries from flow-purified chromosomes

1986 • 52 citations

Detection of species specific chromosomes in somatic cell hybrids

1985 • 42 citations

Simultaneous identification and banding of human chromosome material in somatic cell hybrids

1988 • 29 citations

A straightforward approach to isolate DNA sequences with potential linkage to the retinoblastoma locus

1986 • 18 citations