The KRAS oncogene: Past, present, and future

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Targeting RAS signalling pathways in cancer therapy

2003 • 3,105 citations

Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer

2005 • 2,139 citations

RAS oncogenes: the first 30 years

2003 • 1,788 citations

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

2003 • 998 citations

Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study

2001 • 858 citations

Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects

2004 • 780 citations

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

1982 • 775 citations

Kirsten ras Mutations in Patients With Colorectal Cancer: the Multicenter "RASCAL" Study

1998 • 739 citations

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

1997 • 537 citations

K-Ras is essential for the development of the mouse embryo

1997 • 353 citations

Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study.

2000 • 313 citations

Wildtype Kras2 can inhibit lung carcinogenesis in mice

2001 • 295 citations

K-ras as a target for cancer therapy

2005 • 240 citations

Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice

2002 • 130 citations

Mutant KRAS in the initiation of pancreatic cancer

2005 • 129 citations

Mutant KRAS in aberrant crypt foci (ACF): Initiation of colorectal cancer?

2005 • 110 citations

Mutant KRAS, chromosomal instability and prognosis in colorectal cancer

2005 • 87 citations

Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.

1999 • 68 citations

Control of colorectal metastasis formation by K-Ras

2005 • 60 citations

What is the origin of pancreatic adenocarcinoma?

2003 • 58 citations

Mouse models of K-ras-initiated carcinogenesis

2005 • 26 citations

Stable expression of activated Ki-Ras does not constitutively activate the mitogen-activated protein kinase pathway but attenuates epidermal growth factor receptor activation in human astrocytoma cells.

1999 • 14 citations