Mutant KRAS in the initiation of pancreatic cancer

Cancer Statistics, 2004

2004 • 4,026 citations

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

2005 • 2,369 citations

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

2003 • 2,309 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

2001 • 1,824 citations

Pancreatic Carcinoma

1992 • 1,175 citations

Pancreatic Intraepithelial Neoplasia

2001 • 1,100 citations

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

2003 • 998 citations

Pancreaticoduodenectomy With or Without Distal Gastrectomy and Extended Retroperitoneal Lymphadenectomy for Periampullary Adenocarcinoma, Part 2

2002 • 810 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

1988 • 620 citations

Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma.

1993 • 380 citations

Genetic Progression in the Pancreatic Ducts

2000 • 374 citations

Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease

1996 • 290 citations

Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice

1987 • 271 citations

Pancreatic Neoplasia Induced by SV40 T-Antigen Expression in Acinar Cells of Transgenic Mice

1987 • 243 citations

A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

2001 • 209 citations

Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice.

2003 • 205 citations

Malignant transformation of duct-like cells originating from acini in transforming growth factor α transgenic mice

1998 • 197 citations

The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.

2003 • 184 citations

Identification of K-ras Mutations in Pancreatic Juice in the Early Diagnosis of Pancreatic Cancer

1995 • 170 citations

Pancreatic tumor pathogenesis reflects the causative genetic lesion.

1991 • 158 citations

DNA content and other factors associated with ten-year survival after resection of pancreatic carcinoma

1998 • 124 citations

The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer

2003 • 113 citations

The role ofras mutation in pancreatic cancer, precancerous lesions, and chronic pancreatitis

1993 • 82 citations

Obligate Roles for p16^Ink4a and p19^Arf-p53 in the Suppression of Murine Pancreatic Neoplasia

2002 • 75 citations

Identification of K‐ras Oncogene Mutations in the Pure Pancreatic Juice of Patients with Ductal Pancreatic Cancers

1993 • 70 citations

The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice

2001 • 62 citations

A rat model of pancreatic ductal adenocarcinoma: Targeting chemical carcinogens

1997 • 50 citations

Promoter and enhancer elements from the rat elastase I gene function independently of each other and of heterologous enhancers.

1987 • 31 citations

Detection of ras gene mutations in peripheral blood of carcinoma patients using CD45 immunomagnetic separation and nested mutant allele specific amplification.

1998 • 23 citations

Novel expression of gastrin (CCK-B) receptors in pancreatic carcinomas and dysplastic pancreas from transgenic mice

1994 • 16 citations

Development of an animal model of pancreatic cancer.

1976 • 5 citations