7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Protein folding in the cell

1992 • 4,138 citations

Protein Inhibitors of Proteinases

1980 • 2,220 citations

MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

1993 • 1,591 citations

Homologous plant and bacterial proteins chaperone oligomeric protein assembly

1988 • 1,316 citations

MOLECULAR CHAPERONES

1991 • 1,089 citations

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

Mammalian subtilisins: The long-sought dibasic processing endoproteases

1991 • 756 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

The new enzymology of precursor processing endoproteases.

1992 • 608 citations

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1990 • 579 citations

Association of folding intermediates of glycoproteins with calnexin during protein maturation

1993 • 558 citations

Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.

1989 • 492 citations

Cloning and Primary Sequence of a Mouse Candidate Prohormone Convertase PC1 Homologous to PC2, Furin, and Kex2: Distinct Chromosomal Localization and Messenger RNA Distribution in Brain and Pituitary Compared to PC2

1991 • 475 citations

Protein disulfide isomerase: Multiple roles in the modification of nascent secretory proteins

1989 • 466 citations

Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network.

1991 • 457 citations

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

1991 • 449 citations

Pro-sequence of subtilisin can guide the refolding of denatured subtilisin in an intermolecular process

1989 • 345 citations

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes.

1991 • 317 citations

Carboxypeptidase E

1988 • 308 citations

Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3.

1992 • 300 citations

The trans-most cisternae of the Golgi complex: A compartment for sorting of secretory and plasma membrane proteins

1987 • 275 citations

The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing.

1993 • 259 citations

Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary.

1992 • 256 citations

Peptide α-Amidation

1988 • 241 citations

Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin)

1993 • 203 citations

Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

1990 • 202 citations

Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2

1993 • 182 citations

Proprotein and prohormone convertases of the subtilisin family

1992 • 157 citations

The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.

1993 • 149 citations

Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary

1992 • 141 citations

The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2.

1994 • 141 citations

Isolation and NH₂‐terminal sequence of a novel porcine anterior pituitary polypeptide

1982 • 130 citations

Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily

1983 • 129 citations

Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells.

1992 • 128 citations

Localization of 7B2, Neuromedin B, and Neuromedin U in Specific Cell Types of Rat, Mouse, and Human Pituitary, in Rat Hypothalamus, and in 30 Human Pituitary and Extrapituitary Tumors

1988 • 117 citations

Acetylation of alpha-melanotropin and beta-endorphin in the rat intermediate pituitary. Subcellular localization.

1982 • 111 citations

cDNA and Gene Structure for a Human Subtilisin-Like Protease with Cleavage Specificity for Paired Basic Amino Acid Residues

1991 • 110 citations

Unique composition of plastid chaperonin-60: α and β polypeptide-encoding genes are highly divergent

1990 • 106 citations

Adaptation Physiology : the Functioning of Pituitary Melanotrope Cells during Background Adaptation of the Amphibian Xenopus laevis

1993 • 85 citations

Biosynthesis of the prohormone convertase PC2 in Chinese hamster ovary cells and in rat insulinoma cells.

1993 • 77 citations

Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2

1988 • 70 citations

The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans.

1992 • 67 citations

Autocatalytic maturation of the prohormone convertase PC2.

1994 • 65 citations

The neuroendocrine polypeptide 7B2 is a precursor protein.

1990 • 64 citations

Structure and expression of Xenopus prohormone convertase PC2

1992 • 58 citations

The novel pituitary polypeptide 7B2 is a highly‐conserved protein coexpressed with proopiomelanocortin

1989 • 55 citations

Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells

1992 • 51 citations

cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell tumors of transgenic mice

1989 • 51 citations

The pituitary polypetide “7B2” is associated with LH/FSH and TSH cells and is localized within secretory vesicles

1987 • 48 citations

Structure of the elastase-cathepsin G inhibitor of the leech Hirudo medicinalis.

1980 • 45 citations

Evidence for a novel pituitary protein (7B2) in human brain, cerebrospinal fluid and plasma: Brain concentrations in controls and patients with Alzheimer's disease

1987 • 36 citations

Cloning and Characterization of the Rat Complementary Deoxyribonucleic Acid and Gene Encoding the Neuroendocrine Peptide 7B2*

1991 • 36 citations

Cloning, Characterization, and Sequence of a Porcine cDNA Encoding a Secreted Neuronal and Endocrine Protein

1988 • 28 citations

PEPTIDE a-AMIDATION

1988 • 27 citations

Neuroanatomical and Functional Studies of Peptide Precursor-Processing Enyzmes

1991 • 24 citations

Application of recombinant DNA technology in epitope mapping and targeting

1991 • 20 citations

Coordinated expression of 7B2 and αMSH in the melanotrope cells of Xenopus laevis

1991 • 13 citations

Depolarizing Action of Secretory Granule Protein 7B2 on Rat Supraoptic Neurosecretory Neurons

1993 • 10 citations