Molecular and cellular aspects of HTLV-1 associated leukemogenesis in vivo

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS

1985 • 2,840 citations

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

1982 • 2,170 citations

Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

1983 • 1,555 citations

Population Dynamics of Immune Responses to Persistent Viruses

1996 • 1,218 citations

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1997 • 1,206 citations

Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase

1995 • 1,139 citations

Mutation rates among RNA viruses

1999 • 1,122 citations

Analysis Of Htlv-I Proviral Load In 202 Ham/Tsp Patients And 243 Asymptomatic Htlv-I Carriers: High Proviral Load Strongly Predisposes To Ham/Tsp

1998 • 678 citations

Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease

1990 • 603 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

RNA Virus Populations as Quasispecies

1992 • 523 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control

2001 • 457 citations

Infective dermatitis of Jamaican children: a marker for HTLV-I infection

1990 • 452 citations

HTLV-I Trans-Activator Protein, Tax, is a Trans-Repressor of the Human β-Polymerase Ggene

1990 • 329 citations

Pathogenesis of Diseases Induced by Human Lymphotropic Virus Type I Infection

1993 • 320 citations

Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy

1995 • 308 citations

Viral Quasispecies

1993 • 300 citations

Abundant Tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes

2000 • 274 citations

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

1996 • 273 citations

Low degree of human T-cell leukemia/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations

1992 • 259 citations

Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes.

1987 • 245 citations

Cancer Cells Exhibit a Mutator Phenotype

1997 • 243 citations

Activated, HTLV-1-specific cytotoxic T-lymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis

1992 • 201 citations

Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I.

1992 • 192 citations

Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements.

1989 • 188 citations

Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb

1998 • 188 citations

Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia

2001 • 179 citations

HTLV-1 Tax induces expression of various immediate early serum responsive genes.

1991 • 177 citations

Viral quasi species.

1993 • 175 citations

Inhibition of p53 Transactivation Function by the Human T-Cell Lymphotropic Virus Type 1 Tax Protein

1998 • 174 citations

Persistent clonal proliferation of human T-lymphotropic virus type I-infected cells in vivo.

1997 • 167 citations

Selective Ablation of Human T-Cell Lymphotropic Virus Type 1 p12I Reduces Viral Infectivity In Vivo

1998 • 162 citations

The spontaneous azaguanine-resistant mutants of diploid human fibroblasts

1972 • 161 citations

Increased HTLV‐I proviral DNA in HTLV‐I–associated myelopathy: A quantitative polymerase chain reaction study

1991 • 153 citations

High circulating proviral load with oligoclonal expansion of HTLV-1 bearing T cells in HTLV-1 carriers with strongyloidiasis

2000 • 148 citations

Physical Interaction of Human T-Cell Leukemia Virus Type 1 Tax with Cyclin-Dependent Kinase 4 Stimulates the Phosphorylation of Retinoblastoma Protein

2002 • 140 citations

Clinical diversity in adult T-cell leukemia-lymphoma.

1985 • 131 citations

Disruption of Nucleotide Excision Repair by the Human T-Cell Leukemia Virus Type 1 Tax Protein

1999 • 120 citations

Structure-function analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism of Rex and Rev action.

1990 • 119 citations

Defective DNA Repair in Cells With Human T-Cell Leukemia/Bovine Leukemia Viruses: Role of tax Gene

1999 • 117 citations

Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis/HTLV-1 associated myelopathy

1998 • 110 citations

Clonal Expansion of Infected Cells: A Way of Life for HTLV-I

1996 • 109 citations

X-I and X-II Open Reading Frames of HTLV-I Are Not Required for Virus Replication or for Immortalization of Primary T-Cellsin Vitro

1997 • 106 citations

Frequent clonal proliferation of human T-cell leukemia virus type 1 (HTLV-1)-infected T cells in HTLV-1-associated myelopathy (HAM-TSP)

1992 • 102 citations

Arthritis in patients infected with human T lymphotropic virus type I. Clinical and immunopathologic features

1991 • 101 citations

Evidence for the Chronic in Vivo Production of Human T Cell Leukemia Virus Type I Rof and Tof Proteins from Cytotoxic T Lymphocytes Directed against Viral Peptides

2000 • 99 citations

HTLV-I proviral DNA amount correlates with infiltrating CD4+ lymphocytes in the spinal cord from patients with HTLV-I-associated myelopathy

1994 • 96 citations

Transcriptional Up-Regulation of the Cyclin D2 Gene and Acquisition of New Cyclin-Dependent Kinase Partners in Human T-Cell Leukemia Virus Type 1-Infected Cells

1999 • 92 citations

Transcriptional Repression of p53 by Human T-cell Leukemia Virus Type I Tax Protein

1995 • 89 citations

Human T-Lymphotropic Virus Type 1 Open Reading Frame I p12^IIs Required for Efficient Viral Infectivity in Primary Lymphocytes

2000 • 89 citations

The Etiology of Early Childhood Diarrhea: A Community Study from Guinea-Bissau

1994 • 81 citations

In Vivo Analysis of Human T-Cell Leukemia Virus Type 1 Reverse Transcription Accuracy

2000 • 80 citations

Structure of the human gene for α‐enolase

1990 • 79 citations

Secondary structure of the human T-cell leukemia virus type 1 rex-responsive element is essential for rex regulation of RNA processing and transport of unspliced RNAs

1990 • 79 citations

Activation of Nuclear Factor of Activated T Cells by Human T-Lymphotropic Virus Type 1 Accessory Protein p12 ^I

2002 • 78 citations

Trans-activator Tax of Human T-Cell Leukemia Virus Type 1 Enhances Mutation Frequency of the Cellular Genome

1999 • 78 citations

Functional analysis of human T-cell leukemia virus type I rex-response element: direct RNA binding of Rex protein correlates with in vivo activity

1991 • 76 citations

Selective Ablation of Human T-Cell Lymphotropic Virus Type 1 p12I Reduces Viral Infectivity In Vivo

1998 • 75 citations

Proliferation of HTLV-1 infected circulating cells in vivo in all asymptomatic carriers and patients with TSP/HAM.

1996 • 75 citations

Malaria, Epstein-Barr Virus, and the Genesis of Lymphomas

1989 • 75 citations

Clastogenic Effect of the Human T-cell Leukemia Virus Type I Tax Oncoprotein Correlates with Unstabilized DNA Breaks

2000 • 73 citations

Adult T-cell leukemia/lymphoma not associated with human T-cell leukemia virus type I.

1986 • 71 citations

Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter

1997 • 68 citations

Regression of Human T-cell Leukemia Virus Type I (HTLV-I)-Associated Lymphomas in a Rat Model: Peptide-Induced T-Cell Immunity

2001 • 68 citations

Common Human T Cell Leukemia Virus Type 1 (HTLV‐1) Integration Sites in Cerebrospinal Fluid and Blood Lymphocytes of Patients with HTLV‐1–Associated Myelopathy/Tropical Spastic Paraparesis Indicate that HTLV‐1 Crosses the Blood‐Brain Barrier via Clonal HTLV‐1–Infected Cells

2000 • 67 citations

Human T lymphotropic virus type 1 uveitis.

1994 • 67 citations

Somatic Mutation in Human T-Cell Leukemia Virus Type 1 Provirus and Flanking Cellular Sequences During Clonal Expansion In Vivo

2001 • 64 citations

Adult T-cell leukemia/lymphoma on a background of clonally expanding human T-cell leukemia virus type-1-positive cells

1996 • 62 citations

Lymphoid Organs as a Major Reservoir for Human T-Cell Leukemia Virus Type 1 in Experimentally Infected Squirrel Monkeys (Saimiri sciureus): Provirus Expression, Persistence, and Humoral and Cellular Immune Responses

2000 • 61 citations

Two-Step Nature of Human T-Cell Leukemia Virus Type 1 Replication in Experimentally Infected Squirrel Monkeys ( Saimiri sciureus )

2001 • 60 citations

Genetic Engineering: Principles and Methods

2004 • 59 citations

Complications of RNA Heterogeneity for the Engineering of Virus Vaccines and Antiviral Agents

1992 • 57 citations

Immunogenicity and Protective Efficacy of Recombinant Human T-Cell Leukemia/Lymphoma Virus Type 1 NYVAC and Naked DNA Vaccine Candidates in Squirrel Monkeys (Saimiri sciureus)

2001 • 56 citations

High-resolution mapping of the human T-cell leukemia virus type 1 Rex-binding element by in vitro selection

1995 • 49 citations

An Interactive Framework for RNA Secondary Structure Prediction with a Dynamical Treatment of Constraints

1995 • 48 citations

Genetic Evidence of a Role for ATM in Functional Interaction between Human T-Cell Leukemia Virus Type 1 Tax and p53

2001 • 48 citations

Complex intrapatient sequence variation in the V1 and V2 hypervariable regions of the HIV-1 gp120 envelope sequence

1992 • 48 citations

Development of Human T-Cell Lymphotropic Virus Type I--Associated Adult T-Cell Leukemia/Lymphoma During Immunosuppressive Treatment Following Renal Transplantation

1995 • 47 citations

Adult T‐cell leukemia developing during immunosuppressive treatment in a renal transplant recipient

1992 • 45 citations

Stochastic events in the amplification of HTLV-I integration sites by linker-mediated PCR

1995 • 45 citations

Specific binding of the human T-cell leukemia virus type I Rex protein to a short RNA sequence located within the Rex-response element

1992 • 41 citations

Seven years of recurrent severe strongyloidiasis in an HTLV-l-infected man who developed adult T-cell leukaemia

1992 • 41 citations

Quantification of human T-cell lymphotropic virus type 1 proviral load by quantitative competitive polymerase chain reaction

1998 • 40 citations

A deletion in the proximal untranslated pX region of human T-cell leukemia virus type II decreases viral replication but not infectivity in vivo

1996 • 40 citations

HTLV-I Infection in Squirrel Monkeys (Saı̈miri sciureus) Using Autologous, Homologous, or Heterologous HTLV-I-Transformed Cell Lines

1997 • 39 citations

In Vitroandin VivoFunctional Analysis of Human T Cell Lymphotropic Virus Type 1 pX Open Reading Frames I and II

2000 • 38 citations

HTLV-1 T cell lymphoma in a cyclosporine-treated renal transplant patient.

1989 • 38 citations

Identification of human t cell leukemia/lymphoma virus type i antibodies, dna, and protein in patients with polymyositis

1995 • 36 citations

Human T-Lymphotrophic Viruses and Diseases of Long Latency

1989 • 32 citations

ESSA: an integrated and interactive computer tool for analysing RNA secondary structure

1997 • 29 citations

Quantification of HTLV-1 proviral copy number in peripheral blood of symptomless carriers from the French West Indies.

1992 • 28 citations

Development of Human T-Cell Leukemia Virus Type 1-Transformed Tumors in Rats following Suppression of T-Cell Immunity by CD80 and CD86 Blockade

2000 • 27 citations

Implication of HTLV-I Infection, Strongyloidiasis, and P53 Overexpression in the Development, Response to Treatment, and Evolution of Non-Hodgkin's Lymphomas in an Endemic Area (Martinique, French West Indies)

1999 • 26 citations

Mapping of Multiple RNA Binding Sites of Human T-cell Lymphotropic Virus Type I Rex Protein within 5′- and 3′-Rex Response Elements

1998 • 23 citations

Intestinal Strongyloidiasis Manifesting as Eosinophilic Pleural Effusion

1998 • 22 citations

Lymphocyte alveolitis in HAM/TSP patients: preliminary report

1993 • 14 citations

Semiquantitative analysis of residual disease in patients treated for adult T‐cell leukaemia/lymphoma (ATLL)

1999 • 12 citations

Transient adult T-cell leukemia/lymphoma picture during varicella infection in an HTLV-1 carrier.

1994 • 10 citations

[Strongyloides stercoralis hyperinfection].

1996 • 6 citations

Genetic variation in avian retroviruses.

1990 • 5 citations

PROLIFERATION OF HTLV-1 INFECTED CELLS IN VIVO: PATHOGENIC IMPLICATIONS IN LEUKEMOGENESIS AND NEUROPATHOGENESIS.

1999 • 3 citations