Clonal Expansion of Infected Cells: A Way of Life for HTLV-I

Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

1983 • 1,555 citations

Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase

1995 • 1,139 citations

Natural Selection and the Concept of a Protein Space

1970 • 925 citations

Rates of spontaneous mutation among RNA viruses.

1993 • 707 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease

1990 • 603 citations

RNA Virus Populations as Quasispecies

1992 • 523 citations

In vivo cellular tropism of human T-cell leukemia virus type 1

1990 • 425 citations

Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy

1995 • 308 citations

Viral Quasispecies

1993 • 300 citations

Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction.

1989 • 289 citations

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

1996 • 273 citations

Low degree of human T-cell leukemia/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations

1992 • 259 citations

Genetic Diversity and Evolution of Retroviruses

1992 • 215 citations

Activated, HTLV-1-specific cytotoxic T-lymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis

1992 • 201 citations

Viral quasi species.

1993 • 175 citations

Increased HTLV‐I proviral DNA in HTLV‐I–associated myelopathy: A quantitative polymerase chain reaction study

1991 • 153 citations

Lower mutation rate of bovine leukemia virus relative to that of spleen necrosis virus

1994 • 103 citations

A novel diagnostic method of adult T-cell leukemia: monoclonal integration of human T-cell lymphotropic virus type I provirus DNA detected by inverse polymerase chain reaction

1994 • 97 citations

Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax

1995 • 94 citations

Mutations introduced along the HTLV-I envelope gene result in a non-functional protein: a basis for envelope conservation?

1990 • 76 citations

HTLV-1 tax: regulation of gene expression and disease

1993 • 73 citations

Tax protein of human T-cell leukemia virus type I is required for maintenance of the transformed phenotype.

1992 • 54 citations

Complex intrapatient sequence variation in the V1 and V2 hypervariable regions of the HIV-1 gp120 envelope sequence

1992 • 48 citations

Stochastic events in the amplification of HTLV-I integration sites by linker-mediated PCR

1995 • 45 citations

Semiquantitative analysis of integrated genomes of human T-lymphotropic virus type I in asymptomatic virus carriers

1991 • 39 citations

Frequent mutation in pX region of HTLV-1 is observed in HAM/TSP patients, but is not specifically associated with the central nervous system lesions

1995 • 28 citations

Human T Lymphotropic Virus (HTLV) Type I and II DNA Amplification in HTLV-I/II-Seropositive Blood Donors of the French West Indies

1992 • 23 citations