Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles.

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

The scanning model for translation: an update.

1989 • 3,525 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

1985 • 1,983 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

1987 • 786 citations

Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

1987 • 751 citations

Adenylate cyclase assay.

1979 • 485 citations

Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter

1987 • 361 citations

Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells

1989 • 355 citations

The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits

1988 • 306 citations

Germ-Line Transmission of a c- abl Mutation Produced by Targeted Gene Disruption in ES Cells

1989 • 285 citations

Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells

1988 • 273 citations

G protein multiplicity in eukaryotic signal transduction systems

1988 • 267 citations

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

1987 • 254 citations

Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells

1990 • 248 citations

Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells

1989 • 200 citations

Pertussis Toxin-Sensitive Pathway in the Stimulation of c- myc Expression and DNA Synthesis by Bombesin

1986 • 171 citations

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination

1989 • 166 citations

Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains.

1986 • 159 citations

Polymorphisms in the coding and noncoding regions of murinePgk-1 alleles

1990 • 95 citations

Possible involvement of a GTP-binding protein, the substrate of islet-activating protein, in receptor-mediated signaling responsible for cell proliferation.

1987 • 85 citations

Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines.

1988 • 63 citations

Pertussis Toxin-Catalyzed ADP-Ribosylation: Effects on the Coupling of Inhibitory Receptors to the Adenylate Cyclase System

1984 • 31 citations

Different sensitivity to phorbol esters and pertussis toxin of bombesin- and platelet-derived growth factor-induced, phospholipase C-mediated hydrolysis of phosphoinositides in NIH/3T3 cells

1988 • 22 citations

The G protein alpha o subunit alters morphology, growth kinetics, and phospholipid metabolism of somatic cells.

1989 • 21 citations

Antibodies against synthetic peptides as probes of G protein structure and function.

1990 • 19 citations

The G Protein α_o Subunit Alters Morphology, Growth Kinetics, and Phospholipid Metabolism of Somatic Cells

1989 • 5 citations

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