Renal excretion of urate: Factors determining the actions of drugs

Enzymatic Determination of Uric Acid with Detailed Directions

1953 • 307 citations

STUDY OF THE PARADOXICAL EFFECTS OF SALICYLATE IN LOW, INTERMEDIATE AND HIGH DOSAGE ON THE RENAL MECHANISMS FOR EXCRETION OF URATE IN MAN *

1959 • 205 citations

Characteristics of p-aminohippurate transport in proximal renal tubules

1969 • 196 citations

Factors affecting urate excretion following diuretic administration in man

1969 • 183 citations

‘Benemid,’ p-(di-n-Propylsulfamyl)-Benzoic Acid: Its Renal Affinity and Its Elimination

1951 • 161 citations

TUBULAR SECRETION OF URATE IN MAN*

1959 • 159 citations

Renal tubular transport of water, solute, and PAH in rats loaded with isotonic saline

1965 • 135 citations

Pharmacology of pyrazinamide: metabolic and renal function studies related to the mechanism of drug-induced urate retention.

1972 • 131 citations

Evidence for a Postsecretory Reabsorptive Site for Uric Acid in Man

1973 • 130 citations

The influence of the extracellular fluid volume on the tubular reabsorption of uric acid.

1975 • 127 citations

Hypouricemia: with evidence for tubular elimination of uric acid.

1950 • 126 citations

Relationship between Para-aminohippurate Secretion and Cellular Morphology in Rabbit Proximal Tubules

1978 • 119 citations

A three-component system for regulation of renal excretion of uric acid in man.

1961 • 108 citations

The physiological disposition of probenecid, including renal clearance, in man, studied by an improved method for its estimation in biological material.

1963 • 98 citations

Renal Tubular Transport of Organic Acids

1978 • 82 citations

Tubular secretion of urate in the dog

1960 • 75 citations

Amino Acid Transport and Uric Acid Transport

1977 • 75 citations

The Influence of Hypertonic Saline Infusions Upon the Fractional Reabsorption of Urate and Other Ions in Normal and Hypertensive Man

1970 • 68 citations

Handling of uric acid by the rat kidney

1971 • 65 citations

MUTUAL SUPPRESSION OF THE URICOSURIC EFFECTS OF SULFINPYRAZONE AND SALICYLATE: A STUDY IN INTERACTIONS BETWEEN DRUGS*

1963 • 63 citations

Bidirectional urate transport limited to the proximal tubule in dogs

1968 • 63 citations

PAH transport by snake proximal renal tubules: differences from urate transport

1974 • 62 citations

Urate-2-14C transport in the rat nephron

1971 • 61 citations

A study of the inverse relationship between pKa and rate of renal excretion of phenylbutazone analogs in man and dog

1960 • 58 citations

Localization of urate transport in the nephron of mongrel and Dalmatian dog kidney

1959 • 58 citations

Urinary Excretion of Uric Acid in Nonhuman Mammalian Species

1978 • 57 citations

Urate transport in the nephron

1979 • 57 citations

Characteristics of urate transport by isolated perfused snake proximal renal tubules

1973 • 56 citations

Changes in renal urate handling after prolonged thiazide treatment

1974 • 56 citations

QUANTITATIVE STUDIES OF THE COMPOSITION OF GLOMERULAR URINE

1933 • 54 citations

Functional characteristics of renal urate transport in the Cebus monkey

1970 • 49 citations

Tubular Excretion of Uric Acid in Rabbits.

1954 • 47 citations

Hypouricemia due to Renal Uricosuria

1973 • 46 citations

Renal excretion of uric acid in the dog

1968 • 45 citations

Estimation of serum uric acid by high performance liquid chromatography with electrochemical detection

1975 • 45 citations

Renal excretion of uric acid in the rat: a micropuncture and microperfusion study

1976 • 43 citations

Renal excretion of urate in mongrel and Dalmatian dogs: a micropuncture study

1976 • 42 citations

Proximal tubular reabsorption of some organic acids in the rat kidney in vivo

1965 • 41 citations

Suppression of Tubular Secretion of Urate by Pyrazinamide in the Dog.

1961 • 40 citations

Factors basic to the development of useful inhibitors of renal transport mechanisms.

1954 • 39 citations

Handling of uric acid by the rat kidney

1972 • 39 citations

The Liver-like Anion Transport System in Rabbit Kidney, Uvea and Choroid Plexus. II. Efficiency of Acidic Drugs and Other Anions as Inhibitors

1973 • 38 citations

Suppression of Uric Acid Secretion in a Patient with Renal Hypouricemia

1974 • 37 citations

Renal tubular secretion of uric acid in the mongrel dog

1960 • 37 citations

Stop-flow analysis of tubular transport of uric acid in rabbits

1964 • 37 citations

Distal permeability to urate and effects of benzofuran derivatives in the rat kidney

1975 • 36 citations

Micropuncture study of uric acid transport in rat kidney

1975 • 36 citations

Influence of volume expansion, serum sodium, and fractional excretion of sodium on urate excretion

1975 • 36 citations

Effects of mercurial diuretics on renal transport of urate in the chimpanzee

1973 • 31 citations

Urate handling by the rat kidney

1974 • 30 citations

Excretion of urate by the kidneys of Cebus monkeys: a micropuncture study

1973 • 29 citations

Pyrazinamide suppression of the uricosuric response to sodium chloride infusion.

1974 • 29 citations

Relationship between pKa and Uricosuric Activity in Phenylbutazone Analogues

1958 • 29 citations

Renal urate excretion at various plasma concentrations in the rat: a free-flow micropuncture study

1976 • 29 citations

Nature of the uricosuric action of benziodarone

1973 • 28 citations

Influence of glomerular filtration rate on the rate of para-aminohippurate secretion by the rat kidney: Micropuncture and clearance studies

1975 • 28 citations

Relationship of urate and p-aminohippurate secretion in man

1973 • 28 citations

Etude chez l’homme de la cinétique d’apparition dans l’urine de l’acide urique 2 <sup>14</sup>C

1968 • 27 citations

Permeabilit�tsmessungen einiger schwacher organischer S�uren aus dem distalen Konvolut der Rattenniere

1969 • 27 citations

Uric acid excretion by the pig kidney

1976 • 24 citations

Uric acid metabolism in Cebus monkeys

1971 • 24 citations

Urate clearance in Cebus monkeys

1968 • 23 citations

Urate reabsorption in proximal convoluted tubule of the rat kidney

1976 • 22 citations

The effect of the interaction of pyrazinamide and probenecid on urinary uric acid excretion in man

1977 • 22 citations

Effects of inhibitors in lumen on PAH and urate transport by isolated renal tubules

1979 • 22 citations

Urate Excretion in Man, Normal and Gouty

1978 • 22 citations

Inhibition of Uric Acid Exeretion in Rabbits given Probenecid or Salicylic Acid.

1955 • 21 citations

Comparison of renal tubular transport of urate and PAH in water snakes: Evidence for differences in mechanisms and sites of transport

1970 • 21 citations

Transport ontogeny and selective substrate stimulation as models for identification of multiple renal organic anion transport systems.

1977 • 21 citations

Uricosuric potency of 2-substituted analogs of probenecid.

1972 • 20 citations

Secretion of p-aminohippurate by rat kidney proximal tubules.

1970 • 20 citations

Studies on renal urate secretion in the dog.

1971 • 19 citations

Pharmacologic Approach to the Maintenance of Urate Homeostasis

1975 • 19 citations

Renal Transport of Diatrizoate in the Rabbit, Dog, and Rat

1971 • 18 citations

Effects of intraluminal D-glucose and probenecid on urate absorption in the rat proximal tubule

1979 • 17 citations

Renal clearance of uric acid in nonhuman primates

1970 • 17 citations

Salicylate excretion in the rat; free flow micropuncture experiments.

1978 • 16 citations

Clearance Experiments on the Effect of Probenecid on Urate Excretion in the Rabbit

1965 • 16 citations

Renal excretion and uricosuric properties of halofenate, a hypolipidemic-uricosuric agent, in the chimpanzee.

1972 • 16 citations

The relation between secretion of urate and p‐aminohippurate in the rabbit kidney

1967 • 15 citations

Species variations among primates in responses to drugs which alter the renal excretion of uric acid.

1975 • 15 citations

The Excretion of Urate at Various Plasma Concentrations and During Osmotic Diuresis in the Rabbit

1966 • 14 citations

Drugs Affecting the Renal Handling of Uric Acid

1976 • 14 citations

Characteristics of urate influx in the rat nephron

1975 • 14 citations

Excretion of phenol red by the Necturus kidney

1979 • 13 citations

M�canismes de l'excr�tion d'acide urique chez le rat

1971 • 13 citations

A micropuncture study of urate excretion byCebus monkeys employing high performance liquid chromatography with amperometric detection of urate

1980 • 13 citations

Inhibition of urate excretion by pyrazinoate: a micropuncture study

1975 • 12 citations

Inhibition of probenecid uricosuria by pyrazinamide and para-aminohippurate

1977 • 12 citations

Familial hypouricaemia due to renal tubular defect of urate transport.

1975 • 12 citations

A simple radioisotopic technique for the study of urate transport in the rat kidney.

1974 • 11 citations

Variation of Urate Excretion with Urine Flow in Normal Man

1976 • 11 citations

Urate excretion: drug interactions.

1979 • 11 citations

The Effect of Probenecid on Urate Transport in the Rat Kidney

1977 • 9 citations

The Renal Handling of Tienilic Acid (Ticrynafen), a New Diuretic with Uricosuric Properties

1979 • 8 citations

Uptake of uric acid by separated renal tubules of the rabbit. II. Effects of drugs.

1977 • 8 citations

The renal accumulation of urate and p‐aminohippurate in the rabbit

1967 • 8 citations

Urate excretion and urine flow in a lithium-induced diabetes insipidus rat model

1974 • 8 citations

Uric acid excretion by the rat kidney

1975 • 8 citations

Pyrazinoic Acid and Urate Transport in the Rat

1978 • 7 citations

Uricosuric Drugs

1978 • 5 citations

Accumulation of <i>p</i>-Aminohippurate by Multiple Transport Systems in Rabbit Kidney Cortex Slices: A Kinetic Analysis

1978 • 1 citations