A study of the inverse relationship between pKa and rate of renal excretion of phenylbutazone analogs in man and dog

THE RENAL CLEARANCES OF SUBSTITUTED HIPPURIC ACID DERIVATIVES AND OTHER AROMATIC ACIDS IN DOG AND MAN 1

1945 • 1,598 citations

The Kidney: Structure and Function in Health and Disease

1952 • 1,326 citations

The Permeability of Natural Membranes

1944 • 752 citations

Enzymatic Metabolism of Drugs and other Foreign Compounds

1958 • 501 citations

The gastric secretion of drugs: a pH partition hypothesis.

1957 • 466 citations

The Kidney: Structure and Function in Health and Disease.

1951 • 463 citations

Some Physico-Chemical Factors in Drug Action

1957 • 396 citations

Non-ionic diffusion and the excretion of weak acids and bases

1958 • 377 citations

The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material.

1953 • 240 citations

Detoxication Mechanisms: The Metabolism and Detoxication of Drugs, Toxic Substances and Other Organic Compounds

1960 • 226 citations

The Distribution and Excretion of Phenobarbital1

1957 • 225 citations

STUDY OF THE PARADOXICAL EFFECTS OF SALICYLATE IN LOW, INTERMEDIATE AND HIGH DOSAGE ON THE RENAL MECHANISMS FOR EXCRETION OF URATE IN MAN *

1959 • 205 citations

Cytology and Cell Physiology

1943 • 202 citations

Localization of urine acidification in the mammalian kidney

1960 • 186 citations

TUBULAR SECRETION OF URATE IN MAN*

1959 • 159 citations

The Determination of Ionization by Ultraviolet Spectrophotometry: Its Validity and its Application to the Measurement of the Strength of Very Weak Bases¹

1935 • 158 citations

Detoxication mechanisms : the metabolism and detoxication of drugs, toxic substances and other organic compounds

1959 • 156 citations

THE MECHANISM OF THE EXCRETION OF AMMONIA IN THE DOG

1956 • 145 citations

Cytology and Cell Physiology

1952 • 145 citations

IDENTIFICATION OF SMALL AMOUNTS OF ORGANIC COMPOUNDS BY DISTRIBUTION STUDIES

1947 • 118 citations

On the mechanism of action of probenecid on renal tubular secretion.

1960 • 104 citations

THE ESTIMATION OF BASIC ORGANIC COMPOUNDS IN BIOLOGICAL MATERIAL

1947 • 103 citations

EFFECT OF BENEMID (p-[di-n-PROPYLSULFAMYL]-BENZOIC ACID) ON URATE CLEARANCE AND OTHER DISCRETE RENAL FUNCTIONS IN GOUTY SUBJECTS 1

1952 • 90 citations

A potent new uricosuric agent, the sulfoxide metabolite of the phenylbutazone analogue, G-25671.

1957 • 84 citations

The metabolic fate of phenylbutazone (butazolidin) in man.

1955 • 83 citations

Tubular secretion of urate in the dog

1960 • 75 citations

A STUDY, BY SIMULTANEOUS CLEARANCE TECHNIQUES, OF SALICYLATE EXCRETION IN MAN. EFFECT OF ALKALINIZATION OF THE URINE BY BICARBONATE ADMINISTRATION; EFFECT OF PROBENECID 1

1955 • 70 citations

RENAL CLEARANCE OF EIGHTEEN INDIVIDUAL AMINO ACIDS IN HUMAN SUBJECTS 1

1955 • 68 citations

THE RENAL TUBULAR RESPONSE TO AMINO ACID LOADING 1

1956 • 62 citations

BIOCHEMICAL PHARMACOLOGICAL CONSIDERATIONS OF PHENYLBUTAZONE AND ITS ANALOGUES

1960 • 60 citations

Localization of urate transport in the nephron of mongrel and Dalmatian dog kidney

1959 • 58 citations

THE RELATIONSHIP BETWEEN CHEMICAL STRUCTURE AND PHYSIOLOGICAL RESPONSE

1932 • 57 citations

Studies on the renal excretion of salicylate in the dog.

1959 • 56 citations

Identification of Small Amounts of Organic Compounds by Distribution Studies

1948 • 56 citations

THE EXCRETION OF SALICYLATE

1955 • 50 citations

Tubular Excretion of Uric Acid in Rabbits.

1954 • 47 citations

EFFECT OF PHENYLBUTAZONE (3,5 DIOXO-1,2-DIPHENYL-4-n-BUTYLPYRAZOLIDINE) ON RENAL CLEARANCE OF URATE AND OTHER DISCRETE RENAL FUNCTIONS IN GOUTY SUBJECTS 1

1953 • 41 citations

Factors basic to the development of useful inhibitors of renal transport mechanisms.

1954 • 39 citations

Certain aspects of the pharmacology of the salicylates.

1949 • 37 citations

Renal clearance of lysine in cystinuria

1957 • 34 citations

THE RELATIONSHIP BETWEEN CHEMICAL STRUCTURE AND PHYSIOLOGICAL RESPONSE

1933 • 33 citations

Disparity Between Phenol Red and Diodrast Clearances in the Dog

1956 • 31 citations

Relationship between pKa and Uricosuric Activity in Phenylbutazone Analogues

1958 • 29 citations

Observations on G-25671, A Phenylbutazone Analogue (4-(phenylthioethyl) -1,2-diphenyl 3,5-pyrazolidinedione).

1954 • 27 citations

THE RELATION BETWEEN CHEMICAL STRUCTURE AND PHYSIOLOGICAL DISPOSITION OF A SERIES OF SUBSTANCES ALLIED TO SULFANILAMIDE

1943 • 25 citations

The Kidney

1954 • 24 citations

EFFECT OF A PHENYLBUTAZONE ANALOG (4-[PHENYLTHIOETHYL]-1,2-DIPHENYL 3,5-PYRAZOLIDINEDIONE) ON URATE CLEARANCE AND OTHER DISCRETE RENAL FUNCTIONS IN GOUTY SUBJECTS. EVALUATION AS URICOSURIC AGENT 1

1956 • 15 citations

Kidney, Water and Electrolyte Metabolism

1958 • 14 citations

The Permeability of Natural Membranes

1945 • 13 citations

Excretion of <scp>l</scp>-malic acid in the chicken

1960 • 9 citations

A p-nitro analogue of phenylbutazone possessing potent antirheumatic, sodium retaining and uricosuric properties.

1959 • 5 citations

Excretion of <scp>d</scp>-malic acid in the chicken

1960 • 5 citations