.gamma.-Butyrobetaine hydroxylase: primary and secondary tritium kinetic isotope effects

Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate

1978 • 531 citations

Aliphatic hydroxylation via oxygen rebound. Oxygen transfer catalyzed by iron

1976 • 468 citations

Steady-state analysis of kinetic isotope effects in enzymic reactions

1975 • 376 citations

Use of Hydrogen Isotope Effects to Identify the Attacking Nucleophile in the Enolization of Ketones Catalyzed by Acetic Acid^1-3

1958 • 343 citations

Mechanism of the Prolyl Hydroxylase Reaction

1977 • 260 citations

The role of ascorbate in the prolyl hydroxylase reaction

1978 • 211 citations

Stereochemistry and deuterium isotope effects in camphor hydroxylation by the cytochrome P450cam monooxygenase system

1982 • 189 citations

Use of Isotope Effects to Elucidate Enzyme Mechanism

1982 • 167 citations

Mechanistic deductions from isotope effects in multireactant enzyme mechanisms

1981 • 142 citations

Cofactor Requirements of γ-Butyrobetaine Hydroxylase from Rat Liver

1970 • 133 citations

Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450

1977 • 126 citations

Stereospecific aliphatic hydroxylation by iron-hydrogen peroxide. Evidence for a stepwise process

1976 • 122 citations

pH Variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same

1981 • 118 citations

Kinetic and chemical mechanisms of yeast formate dehydrogenase

1980 • 117 citations

3-Carbanionic substrate analogues bind very tightly to fumarase and aspartase.

1980 • 114 citations

Hydroxylation of γ-Butyrobetaine to Carnitine in Rat Liver^*

1967 • 114 citations

Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase

1981 • 111 citations

Hepatic synthesis of carnitine from protein-bound trimethyl-lysine. Lysosomal digestion of methyl-lysine-labelled asialo-fetuin

1976 • 107 citations

Prolyl 4-hydroxylase activity in relation to the oxidation state of enzyme-bound iron

1982 • 107 citations

Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions

1980 • 107 citations

pH Variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase

1981 • 100 citations

Use of isotope effects to deduce the chemical mechanism of fumarase

1980 • 85 citations

The Proton Transfer Reactions of Muscle Pyruvate Kinase

1972 • 77 citations

Studies on the lysyl hydroxylase reaction. II. Inhibition kinetics and the reaction mechanism

1980 • 77 citations

The Mechanism of Action of Ethanolamine Ammonia-Lyase, a B12-dependent Enzyme

1971 • 71 citations

Determination of the rate-limiting steps for malic enzyme by the use of isotope effects and other kinetic studies

1977 • 64 citations

Prolyl hydroxylase half reaction: peptidyl prolyl-independent decarboxylation of alpha-ketoglutarate.

1978 • 60 citations

Purification and properties of γ-butyrobetaine hydroxylase from Pseudomonas species AK 1

1977 • 60 citations

Deduction of kinetic mechanism in multisubstrate enzyme reactions from tritium isotope effects. Application to dopamine beta-hydroxylase.

1980 • 58 citations

Mechanism of action of enolase: effect of the .beta.-hydroxy group on the rate of dissociation of the .alpha.-carbon-hydrogen bond

1980 • 53 citations

Mechanism of .alpha.-ketoglutarate oxidation in coupled enzymic oxygenations

1969 • 52 citations

Partial reaction of prolyl hydroxylase. (Gly-PRO-Ala)n stimulates alpha-ketoglutarate decarboxylation without prolyl hydroxylation.

1978 • 51 citations

γ-Butyrobetaine hydroxylase from Pseudomonas sp AK 1

1970 • 50 citations

Mechanistic studies on the rat kidney flavoenzyme L-α-hydroxy acid oxidase

1975 • 50 citations

Thin-layer chromatography of betaines and other compounds related to carnitine

1965 • 45 citations

The kinetics of the chromic acid oxidation of diphenylmethane

1960 • 41 citations

Stereochemistry of reactions catalyzed by glutamate decarboxylase

1978 • 40 citations

α-Ketoglutarate dependent dioxygenases: A mechanism for prolyl hydroxylase action

1979 • 38 citations

Purification and properties of calf liver γ-butyrobetaine hydroxylase

1981 • 38 citations

α‐Ketoglutarate in biological hydroxylations

1968 • 33 citations

Uncoupling in the γ-butyrobetaine hydroxylase reaction by D=- and L=-carnitine

1982 • 31 citations

A simplified method for the measurement of gamma-butyrobetaine hydroxylase activity.

1978 • 25 citations

194. Action de l'acide nitreux sur le glycocolle et sur les polypeptides du glycocolle)

1946 • 20 citations

Studies on the partial reaction of thymine 7-hydroxylase in the presence of 5-fluorouracil

1982 • 18 citations