Association of β-Arrestin with G Protein-coupled Receptors during Clathrin-mediated Endocytosis Dictates the Profile of Receptor Resensitization

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION

1998 • 1,074 citations

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

The β ₂ -adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

1999 • 615 citations

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

1992 • 531 citations

Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness

1998 • 501 citations

Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization

1996 • 450 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

A β-Arrestin/Green Fluorescent Protein Biosensor for Detecting G Protein-coupled Receptor Activation

1997 • 420 citations

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

1993 • 387 citations

Arrestin Interactions with G Protein-coupled Receptors

1995 • 385 citations

A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.

1994 • 361 citations

The Role of Sequestration in G Protein-coupled Receptor Resensitization

1997 • 356 citations

Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization.

1995 • 343 citations

G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

1996 • 332 citations

G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

1996 • 264 citations

Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor

1997 • 252 citations

Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

1993 • 234 citations

A Central Role for ॆ-Arrestins and Clathrin-coated Vesicle-mediated Endocytosis in ॆ2-Adrenergic Receptor Resensitization

1997 • 234 citations

Synergistic Regulation of β₂-Adrenergic Receptor Sequestration: Intracellular Complement of β-Adrenergic Receptor Kinase and β-Arrestin Determine Kinetics of Internalization

1997 • 231 citations

Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.

1986 • 221 citations

Role of Phosphorylation in Agonist-promoted β2-Adrenergic Receptor Sequestration

1995 • 213 citations

Cellular Trafficking of G Protein-coupled Receptor/β-Arrestin Endocytic Complexes

1999 • 213 citations

Dynamic Complexes of β2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role of Gravin

1999 • 208 citations

Visualization of G Protein-coupled Receptor Trafficking with the Aid of the Green Fluorescent Protein

1997 • 176 citations

Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors.

1996 • 154 citations

Interaction of Arrestins with Intracellular Domains of Muscarinic and α2-Adrenergic Receptors

1997 • 139 citations

Regulation of Rhodopsin Dephosphorylation by Arrestin

1989 • 134 citations

A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs.

1990 • 130 citations

A serine cluster prevents recycling of the V2 vasopressin receptor

1998 • 128 citations

Binding of wild type and chimeric arrestins to the m2 muscarinic cholinergic receptor

1993 • 96 citations

Agonist Regulation of α1B-Adrenergic Receptor Subcellular Distribution and Function

1995 • 95 citations

Desensitization of the Neurokinin-1 Receptor (NK1-R) in Neurons: Effects of Substance P on the Distribution of NK1-R, G_αq/11, G-Protein Receptor Kinase-2/3, and β-Arrestin-1/2

1998 • 92 citations

Receptor Subtype-specific Regulation of Muscarinic Acetylcholine Receptor Sequestration by Dynamin

1998 • 88 citations

Phosphorylation of the V2 Vasopressin Receptor

1997 • 80 citations

Signaling and Phosphorylation-impaired Mutants of the Rat Follitropin Receptor Reveal an Activation- and Phosphorylation-independent but Arrestin-dependent Pathway for Internalization

1998 • 69 citations

Agonist-induced Sequestration, Recycling, and Resensitization of Platelet-activating Factor Receptor

1998 • 62 citations

Mutation of Individual Serine Residues in the C-terminal Tail of the Lutropin/Choriogonadotropin Receptor Reveal Distinct Structural Requirements for Agonist-induced Uncoupling and Agonist-induced Internalization

1998 • 55 citations

Transient Phosphorylation of the V1a Vasopressin Receptor

1998 • 54 citations

Desensitization of the human V2 vasopressin receptor. Homologous effects in the absence of heterologous desensitization.

1992 • 43 citations

Agonist and Antagonist-Dependent Internalization of the Human Vasopressin V2Receptor

1998 • 39 citations

A Segment Corresponding to Amino Acids Val170-Arg182 of Bovine Arrestin is Capable of Binding to Phosphorylated Rhodopsin

1994 • 30 citations

A Segment Corresponding to Amino Acids Val170-Arg182 of Bovine Arrestin is Capable of Binding to Phosphorylated Rhodopsin

1994 • 27 citations