Upstream regulatory elements necessary for expression of the rat COL1A1 promoter in transgenic mice

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

A novel rapid assay for chloramphenicol acetyltransferase gene expression

1987 • 802 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

Parathyroid Hormone-Responsive Clonal Cell Lines from Rat Osteosarcoma*

1980 • 483 citations

Globin gene regulation and switching: Circa 1990

1990 • 463 citations

Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria.

1980 • 387 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells.

1987 • 195 citations

Effects of Glucocorticoids on Fetal Rat Bone Collagen Synthesis in Vitro*

1979 • 175 citations

Isolation and characterization of the rat α1(I) collagen promoter

1989 • 145 citations

The first intron of the alpha 1(I) collagen gene contains several transcriptional regulatory elements.

1988 • 140 citations

DNA sequences in the first intron of the human pro-alpha 1(I) collagen gene enhance transcription.

1987 • 135 citations

Differential utilization of regulatory domains within the alpha 1(I) collagen promoter in osseous and fibroblastic cells.

1992 • 134 citations

Parathyroid hormone alters collagen synthesis and procollagen mRNA levels in fetal rat calvaria.

1980 • 127 citations

Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene.

1989 • 121 citations

Pretranslational regulation of type I collagen, fibronectin, and a 50-kilodalton noncollagenous extracellular protein by dexamethasone in rat fibroblasts.

1986 • 114 citations

Diminished type I collagen synthesis and reduced alpha 1(I) collagen messenger RNA in cultured fibroblasts from patients with dominantly inherited (type I) osteogenesis imperfecta.

1985 • 113 citations

Hormonal Regulation of Collagen Synthesis in a Clonal Rat Osteosarcoma Cell Line*

1986 • 100 citations

Frameshift mutation near the 3' end of the COL1A1 gene of type I collagen predicts an elongated Pro alpha 1(I) chain and results in osteogenesis imperfecta type I.

1990 • 91 citations

1,25-Dihydroxyvitamin D₃Inhibits Transcription of Type I Collagen Genes in the Rat Osteosarcoma Cell Line ROS 17/2.8*

1989 • 88 citations

Point mutations and small substitution mutations in three different upstream elements inhibit the activity of the mouse alpha 2(I) collagen promoter.

1988 • 84 citations

Phenotype-Associated Changes in the Effects of 1,25-Dihydroxyvitamin D₃on Alkaline Phosphatase and Bone GLA-Protein of Rat Osteoblastic Cells*

1986 • 84 citations

An upstream regulatory region mediates high-level, tissue-specific expression of the human alpha 1(I) collagen gene in transgenic mice.

1991 • 83 citations

The Effect of Dexamethasone on Parathyroid Hormone Stimulation of Adenylate Cyclase in ROS 17/2.8 Cells*

1984 • 81 citations

The mRNAs for the pro-alpha 1(I) and pro-alpha 2(I) chains of type I procollagen are translated at the same rate in normal human fibroblasts and in fibroblasts from two variants of osteogenesis imperfecta with altered steady state ratios of the two mRNAs.

1983 • 79 citations

Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells.

1992 • 78 citations

Conservation of binding sites for regulatory factors in the coordinately expressed α1(I) and α2(I) collagen promoters

1991 • 71 citations

Minimal DNA sequences that control the cell lineage-specific expression of the pro alpha 2(I) collagen promoter in transgenic mice.

1992 • 71 citations

Bone cell differentiation: A functionally coupled relationship between expression of cell-growth- and tissue-specific genes

1990 • 64 citations

Transgenic expression of COL1A1-chloramphenicol acetyltransferase fusion genes in bone: differential utilization of promoter elements in vivo and in cultured cells.

1993 • 64 citations

Multiple regulatory effects by transforming growth factor-beta on type I collagen levels in osteoblast-enriched cultures from fetal rat bone.

1992 • 57 citations

Parathyroid hormone represses alpha 1(I) collagen promoter activity in cultured calvariae from neonatal transgenic mice.

1993 • 50 citations

Steady-State mRNA Levels of Collagens I, III, Fibronectin, and Collagenase in Skin Biopsies of Systemic Sclerosis Patients

1991 • 40 citations

Interleukin-1α and Phorbol Ester Inhibit Collagen Synthesis in Osteoblastic MC3T3-E1 Cells by a Transcriptional Mechanism

1990 • 39 citations

Regulation of type I collagen synthesis. Total proalpha1(I) and proalpha2(I) mRNAs are maintained in a 2: 1 ratio under varying rates of collagen synthesis

1985 • 34 citations

Simple, inexpensive preparation of T1/T2 ribonuclease suitable for use in RNase protection experiments.

1992 • 19 citations