A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Toll-Like Receptors

2003 • 6,127 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Toll-like receptors in the induction of the innate immune response

2000 • 3,052 citations

CpG Motifs in Bacterial DNA and Their Immune Effects

2002 • 2,520 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

2001 • 1,989 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Innate Immunity

2000 • 1,715 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 • 1,498 citations

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

1999 • 1,381 citations

Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells

2002 • 1,305 citations

Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

1998 • 1,145 citations

Dendritic Cell Subsets and Lineages, and Their Functions in Innate and Adaptive Immunity

2001 • 1,010 citations

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

2001 • 798 citations

Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

2001 • 792 citations

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

2002 • 724 citations

Cellular Origin of Human B-Cell Lymphomas

1999 • 718 citations

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

1998 • 667 citations

Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells

2000 • 604 citations

Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite

2001 • 593 citations

Delineation of a CpG Phosphorothioate Oligodeoxynucleotide for Activating Primate Immune Responses In Vitro and In Vivo

2000 • 593 citations

Mammalian Toll-like receptors

2003 • 589 citations

The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)

1998 • 581 citations

Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells

2001 • 571 citations

Evidence for a Large Compartment of IgM-Expressing Memory B Cells in Humans

1997 • 329 citations

Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ: a molecular basis for priming and synergism with bacterial lipopolysaccharide

2002 • 289 citations

MECHANISM OF THYMUS-INDEPENDENT IMMUNOCYTE TRIGGERING

1974 • 230 citations

Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes

2000 • 181 citations

The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105

1998 • 97 citations

Distinct Response of Human B Cell Subpopulations in Recognition of an Innate Immune Signal, CpG DNA

2002 • 62 citations