Acrolein health effects

Body composition of reference children from birth to age 10 years

1982 • 1,260 citations

Chemically-induced alterations in sexual and functional development : the wildlife/human connection

1992 • 1,087 citations

Pesticides in the Diets of Infants and Children

1993 • 835 citations

Reference dose (RfD): Description and use in health risk assessments

1988 • 757 citations

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride

1987 • 639 citations

Protein-bound acrolein: Potential markers for oxidative stress

1998 • 622 citations

Screening of tabacco smoke constituents for mutagenicity using the Ames' test

1980 • 611 citations

Naturally occurring carbonyl compounds are mutagens Salmonella tester strain TA104

1985 • 596 citations

Detection of chemical mutagens by the dominant lethal assay in the mouse

1972 • 572 citations

Absorption and Retention of Lead by Infants

1978 • 561 citations

Phytoestrogens: epidemiology and a possible role in cancer protection.

1995 • 558 citations

Acrolein Is a Product of Lipid Peroxidation Reaction

1998 • 521 citations

Sensory Irritation by Airborne Chemicals

1973 • 410 citations

Principles and methods of toxicology

1995 • 407 citations

Protein‐Bound Acrolein

1999 • 394 citations

Clinical Pharmacokinetics in Newborns and Infants Age-related Differences and Therapeutic Implications

1980 • 388 citations

Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation.

1997 • 375 citations

Chemical mutagenesis testing in drosophila. IV. Results of 45 coded compounds tested for the national toxicology program

1985 • 318 citations

Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde.

1984 • 295 citations

Evidence for increasing incidence of abnormalities of the human testis: a review.

1993 • 289 citations

A critical review of the literature on acrolein toxicity

1985 • 277 citations

Developmental Expression of CYP2E1 in the Human Liver

1996 • 264 citations

Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems

1980 • 261 citations

Reaction of Glutathione with Conjugated Carbonyls

1975 • 256 citations

Similarities and differences between children and adults: implications for risk assessment

1992 • 250 citations

PHARMACOGENETICS IN PEDIATRICS

1997 • 243 citations

The Blood-Testis Barrier

1980 • 238 citations

Respiratory tract lesions induced by sensory irritants at the RD50 concentration

1984 • 222 citations

Risk Assessment Extrapolations and Physiological Modeling

1985 • 217 citations

Antioxidants and Cancer. IV. Initiating Activity of Malonaldehyde as a Carcinogen

1974 • 213 citations

Glomerular filtration rate, effective renal bloodflow, and maximal tubular excretory capacity in infancy

1948 • 213 citations

Trends in Cancer Mortality in 15 Industrialized Countries, 1969-1986

1992 • 207 citations

Fetus-specific expression of a form of cytochrome P-450 in human livers

1990 • 205 citations

THE DEVELOPMENT OF THE HUMAN BLOOD‐CSF‐BRAIN BARRIER

1985 • 197 citations

Permeability and vascularity of the developing brain: Cerebellum vs cerebral cortex

1980 • 197 citations

General and Applied Toxicology

1994 • 188 citations

Acrolein-induced oxygen radical formation

1993 • 182 citations

Comparison of alkylation rates and mutagenicity of directly acting industrial and laboratory chemicals

1980 • 179 citations

The reaction of cysteine with α,β-unsaturated aldehydes

1976 • 160 citations

Mutagenic properties of allylic and α,β-unsaturated compounds: Consideration of alkylating mechanisms

1982 • 158 citations

EFFECT OF POSSIBLE SMOG IRRITANTS ON HUMAN SUBJECTS

1957 • 154 citations

Acrolein induces oxidative stress in brain mitochondria

2004 • 153 citations

Mutagenicity of vinyl compounds in salmonella typhimurium

1981 • 152 citations

Validation of two in vitro test systems for estrogenic activities with zearalenone, phytoestrogens and cereal extracts

1992 • 149 citations

Evaluation of herbicides for possible mutagenic properties

1972 • 149 citations

Structure-mutagenicity relationship in α,β-unsaturated carbonylic compounds and their corresponding allylic alcohols

1982 • 145 citations

Evaluation of the SOS chromotest

1988 • 144 citations

Pathobiological effects of acrolein in cultured human bronchial epithelial cells.

1988 • 135 citations

Cytotoxicity, DNA cross-linking, and single strand breaks induced by activated cyclophosphamide and acrolein in human leukemia cells.

1986 • 132 citations

Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice

1977 • 131 citations

Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells

2002 • 130 citations

Forage plant estrogens

1978 • 129 citations

Cytotoxicity, thiol depletion and inhibition of O⁶-methylguanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts

1985 • 122 citations

The assay of acute vapor toxicity, and the grading and interpretation of results on 96 chemical compounds.

1949 • 119 citations

Changes in the Nasal Epithelium of Rats Exposed by Inhalation to Mixtures of Formaldehyde, Acetaldehyde, and Acrolein

1996 • 118 citations

Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention—I

1981 • 112 citations

Retention of Inhaled Formaldehyde, Propionaldehyde, and Acrolein in the Dog

1972 • 110 citations

Acrolein-induced cell death in PC12 cells: Role of mitochondria-mediated oxidative stress

2005 • 110 citations

Repeated exposure to acrolein vapour: Subacute studies in hamsters, rats and rabbits

1978 • 108 citations

Evaluation of the Mutagenic Potential of the Principal DNA Adduct of Acrolein

2001 • 108 citations

The biotransformation of allyl alcohol and acrolein in rat liver and lung preparations.

1980 • 107 citations

A Toxicologieal Investigation of Lower Aliphatic Aldehydes.: I. Toxicity of Formaldehyde, Acetaldehyde, Propionaldehyde and Butyraldehyde; as well as of Acrolein and Crotonaldehyde.

1950 • 107 citations

Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid

2002 • 106 citations

Carcnogenicity of epoxides, lactones, and peroxy compounds. VI. Structure and carcinogenic activity.

1967 • 106 citations

Physiologically Based Pharmacokinetic Modeling of Chemical Mixtures

1994 • 102 citations

Sensory irritation structure-activity study of inhaled aldehydes in B6C3F1 and Swiss-Webster mice

1984 • 101 citations

Acrolein induces axolemmal disruption, oxidative stress, and mitochondrial impairment in spinal cord tissue

2003 • 99 citations

Mutagenesis by Acrolein-Derived Propanodeoxyguanosine Adducts in Human Cells

2002 • 99 citations

Non-mutagenicity of 27 aliphatic acrylate esters in the Salmonella-microsome test

1984 • 98 citations

Biosynthesis of mercapturic acids from allyl alcohol, allyl esters and acrolein

1973 • 88 citations

Mutagenesis of xeroderma pigmentosum fibroblasts by acrolein

1988 • 85 citations

Cytogenetic toxicity of cyclophosphamide and its metabolites in vitro

1980 • 82 citations

Altered lung function and structure in the rat after subchronic exposure to acrolein.

1986 • 81 citations

The effectiveness of N-acetylcysteine in isolated hepatocytes, against the toxicity of paracetamol, acrolein, and paraquat

1984 • 79 citations

Studies on mutagenic constituents of apple brandy and various alcoholic beverages collected in western France, a high incidence area for oesophageal cancer

1981 • 78 citations

Decrease of reduced glutathione in isolated rat hepatocytes caused by acrolein, acrylonitrile, and the thermal degradation products of styrene copolymers

1980 • 78 citations

Molecular analysis of mutations induced by acrolein in human fibroblast cells using supF shuttle vector plasmids

1998 • 76 citations

Depletion of nasal mucosal glutathione by acrolein and enhancement of formaldehyde-induced DNA-protein cross-linking by simultaneous exposure to acrolein

1985 • 76 citations

Inhibition of NFκB Activation and IL-8 Expression in Human Bronchial Epithelial Cells by Acrolein

2004 • 76 citations

Induction of thioredoxin reductase as an adaptive response to acrolein in human umbilical vein endothelial cells

2004 • 75 citations

Further Tests for Tumour-Initiating Activity: N,N-DI-(2-Chloroethyl)-P-Aminophenylbutyric Acid (CB1348) as an Initiator of Skin Tumour Formation in the Mouse

1956 • 74 citations

Review and Analysis of Inhalation Dosimetry Methods for Application to Children’s Risk Assessment

2005 • 72 citations

Strong Protein Adduct Trapping Accompanies Abolition of Acrolein-Mediated Hepatotoxicity by Hydralazine in Mice

2004 • 71 citations

Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the national toxicology program

1985 • 71 citations

Molecular requirements for the mutagenicity of malondialdehyde and related acroleins.

1984 • 71 citations

Induction of cellular glutathione and glutathione S-transferase by 3H-1,2-dithiole-3-thione in rat aortic smooth muscle A10 cells: protection against acrolein-induced toxicity

2003 • 70 citations

The effects of inhalation of organic chemical air contaminants on murine lung host defenses*1

1986 • 68 citations

Repeated and continuous exposure of laboratory animals to acrolein

1970 • 67 citations

Immediate sensory nerve-mediated respiratory responses to irritants in healthy and allergic airway-diseased mice

2003 • 65 citations

Regulation of constitutive neutrophil apoptosis by the α,β-unsaturated aldehydes acrolein and 4-hydroxynonenal

2005 • 64 citations

Studies on the mechanism of denaturation of cytochrome P-450 by cyclophosphamide and its metabolites.

1981 • 64 citations

Protein Adduct-Trapping by Hydrazinophthalazine Drugs: Mechanisms of Cytoprotection Against Acrolein-Mediated Toxicity

2004 • 60 citations

Acrolein mutagenicity in the V79 assay

1990 • 60 citations

Effects of exposure to acrolein vapor in hamsters simultaneously treated with benzo[a]pyrene or diethylnitrosamine

1977 • 59 citations

Sensory Irritation and Pulmonary Irritation by Airborne AUyl Acetate, AUyl Alcohol, and Allyl Ether Compared to Acrolein

1984 • 58 citations

Experimentelle reizwirkungen von akrolein auf den menschen

1977 • 57 citations

Genotoxic Mechanism for the Major Acrolein-Derived Deoxyguanosine Adduct in Human Cells

2002 • 57 citations

Sensory nerve-mediated immediate nasal responses to inspired acrolein

1999 • 54 citations

Synthetic smoke with acrolein but not HCl produces pulmonary edema

1988 • 52 citations

Animal test alternatives: refinement, reduction, replacement.

1995 • 50 citations

The effects of acrolein exposure on pulmonary antibacterial defenses

1983 • 50 citations

Studies on the in vivo formation of acrolein: 3-hydroxy-propylmercapturic acid as an index of cyclophosphamide (NSC-26271) activation.

1976 • 50 citations

Metabolism and Distribution of [2,3-¹⁴C]Acrolein in Sprague-Dawley Rats

1998 • 48 citations

Formation, toxicity and inactivation of acrolein during biotransformation of cyclophosphamide as studied in freshly isolated cells from rat liver and kidney

1985 • 47 citations

Acrolein produces nitric oxide through the elevation of intracellular calcium levels to induce apoptosis in human umbilical vein endothelial cells: Implications for smoke angiopathy

2005 • 47 citations

Biochemical effects in rats from irritating air contaminants

1964 • 47 citations

Application of an immunoassay for cyclic acrolein deoxyguanosine adducts to assess their formation in DNA of Salmonella typhimurium under conditions of mutation induction by acrolein

1989 • 46 citations

Metabolism and Distribution of [2,3-14C]Acrolein in Sprague-Dawley Rats

1996 • 45 citations

Effect of acrolein and glutathione depleting agents on thioredoxin

2004 • 45 citations

A new pathway of acrolein metabolism in rats

1983 • 45 citations

Ultrastructural observations on chemically induced inflammation in guinea pig trachea

1972 • 44 citations

Chronic Carcinogenesis Studies of Acrolein and Related Compounds

1987 • 44 citations

Changes in rat lung structure and composition as a result of subchronic exposure to acrolein☆

1985 • 43 citations

Evaluation of sensory irritation from acrolein-formaldehyde mixtures

1978 • 42 citations

Two‐year toxicity and carcinogenicity study of acrolein in rats

1992 • 42 citations

Mechanism of the effect of acrolein on rat liver enzymes

1965 • 39 citations

Uptake of Acrolein in the Upper Respiratory Tract of the F344 Rat

1996 • 38 citations

Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds. V. Subcutaneous Injection in Rats<xref ref-type="fn" rid="FN1">2</xref>

1967 • 37 citations

Mutagenic activity of major mammalian metabolites of cyclophosphamide toward several genes ofEscherichia coli

1977 • 37 citations

Formation of Acrolein Adducts with 2‘-Deoxyadenosine in Calf Thymus DNA

2006 • 36 citations

Toxicity, interstrand cross-links and DNA fragmentation induced by ‘activated’ cyclophosphamide in yeast: Comparative studies on 4-hydroperoxy-cyclophosphamide, its monofunctional analogon, acrolein, phosphoramide mustard, and nor-nitrogen mustard

1982 • 36 citations

Original Articles Mechanism of Respiratory Effects During Exposure of Guinea Pigs to Irritants

1967 • 35 citations

Leukocyte recruitment to airways by aldehyde-carbon combinations that mimic cigarette smoke.

1978 • 35 citations

In vivo metabolism of the cardiovascular toxin, allylamine

1987 • 33 citations

Endometriosis: Advanced Management and Surgical Techniques

1995 • 33 citations

Rat urinary bladder epithelial lesions induced by acrolein.

1989 • 32 citations

The pathologic and immunologic effects of inhaled acrolein in rats

1987 • 32 citations

Respiratory response of guinea pigs during acrolein inhalation and its modification by drugs.

1963 • 29 citations

Relationship between chemical structure and mutagenic activity in some pesticides: the use of Salmonella typhimurium and Aspergillus nidulans

1977 • 29 citations

Effect of thiols on toxicity and carcinostatic activity of cyclophosphamide.

1983 • 28 citations

Mutagenic Activity of Acrolein inS. typhimurium andE. coli

1996 • 25 citations

Sulfidopeptide leukotrienes mediate acrolein-induced bronchial hyperresponsiveness

1989 • 25 citations

Acrolein-Induced Toxicity—Defective Mitochondrial Function as a Possible Mechanism

1999 • 25 citations

Effects of acrolein on DNA synthesis in vitro

1973 • 24 citations

Acrolein depletes the neuropeptides CGRP and substance P in sensory nerves in rat respiratory tract.

1990 • 22 citations

The detection of mutagenic activity of chemicals and tobacco smoke in a bacterial system

1975 • 22 citations

Effects of acrolein on transcription in vitro

1971 • 22 citations

Oncogenicity Study of Acrolein in Mice

1991 • 22 citations

Developmental Toxicity of Acrolein in New Zealand White Rabbits

1993 • 22 citations

Selected responses of hypertension-sensitive and resistant rats to inhaled acrolein

1984 • 21 citations

Action of Intensive Cigarette Smoke Inhalations on the Rat Lung. Role of Particulate and Gaseous Cofactors2

1980 • 20 citations

Irritant dermatitis from diallylglycol carbonate monomer in the optical industry

1976 • 20 citations

One‐year toxicity of orally administered acrolein to the beagle dog

1992 • 20 citations

Reproductive study of acrolein on two generations of rats

1992 • 20 citations

The study of mutagenic activity of carcinogens and other chemical agents with Salmonella typhimurium assays: testing of 126 compounds.

1987 • 19 citations

Irritancy of cyclophosphamide-derived aldehydes (Acrolein, Chloracetaldehyde) and their effect on lymphocyte distribution in vivo: Protective effect of thiols and bisulphite ions

1975 • 18 citations

URTICARIA DUE TO ALIPHATIC ALDEHYDES

1941 • 18 citations

Comparison of Protection byl-ascorbic acid,l-cysteine, and adrenergic-blocking agents against acetaldehyde, acrolein, and formaldehyde toxicity: Implications in smoking

1979 • 16 citations

Acrolein as a Possible Metabolite of Cyclophosphamide in Man

1974 • 15 citations

In vitro effects of trans-4-hydroxy-2-alkenals on mouse liver cytochrome P-450

1987 • 15 citations

Gas Chromatographic Study of Cholesterol Esterification during Postheparin Lipolysis in Vitro in Hypertriglyceridemia

1978 • 14 citations

Experimental Cytoxan Cystitis and Prevention by Acetylcysteine

1985 • 14 citations

Acrolein Depletes the Neuropeptides CGRP and Substance P in Sensory Nerves in Rat Respiratory Tract

1990 • 14 citations

Effects of acrolein on macrophage functions in rats

1986 • 13 citations

Interactions of sulfur dioxide and acrolein as sensory irritants

1979 • 12 citations

In vitro binding of3H-acrolein to regenerating rat liver DNA polymerase

1974 • 11 citations

[Effects in the rat of a weak dose of acrolein inhaled continuously].

1975 • 10 citations

The synthesis of mercapturic acids from allyl compounds in the rat

1972 • 10 citations

Inhalation Toxicology. VII. Times To Incapacitation and Death for Rats Exposed Continuously to Atmospheric Acrolein Vapor

1986 • 9 citations

Aldehyde-Induced Cytotoxicity in Cultured Human Bronchial Epithelial Cells

1987 • 7 citations

[Mutagenic effects of acrolein and its two epoxides, glycidol and glycidal, on Saccharomyces cerevisiae].

1973 • 6 citations

[Experimental respiratory lesions by inhalation of acrolein in the rat].

1966 • 6 citations

[A case of acute acrolein poisoning].

1979 • 6 citations

[Acute broncho-pneumopathy from acrolein vapors].

1966 • 4 citations

Synergistic inactivation of plasma ?1-proteinase inhibitor by aldehydes of cigarette smoke with styrene oxide and 1,2-dichloroethane

1988 • 3 citations

Notizen: Katalytische Hydrierung ungesättigter Verbindungen mit H₂PtCl₆-SnCl₂ · 2 H₂O in Essigsäure / Catalytic Hydrogenation of Unsaturated Compounds with H₂PtCl₆-SnCl₂ · 2 H₂O in Acetic Acid

1975 • 3 citations

The effect of air pollutants on the eye. II. A study on their effect on the oculocardiac reflex.

1971 • 2 citations