A cre recombinase transgene with mosaic, widespread tamoxifen‐inducible action

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

Inducible Gene Targeting in Mice

1995 • 1,897 citations

The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory

1996 • 1,750 citations

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

1998 • 1,272 citations

Cre recombinase: The universal reagent for genome tailoring

2000 • 1,197 citations

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.

1988 • 1,180 citations

Regulation of Cre Recombinase Activity by Mutated Estrogen Receptor Ligand-Binding Domains

1997 • 958 citations

Ligand-activated site-specific recombination in mice.

1996 • 885 citations

Reversible Tumorigenesis by MYC in Hematopoietic Lineages

1999 • 871 citations

Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon cre-mediated excision

2000 • 841 citations

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ERT and Cre-ERT2 recombinases

1999 • 733 citations

Targeted oncogene activation by site-specific recombination in transgenic mice.

1992 • 687 citations

An efficient salt-chloroform extraction of DNA from blood and tissues.

1989 • 638 citations

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

1998 • 571 citations

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase.

1995 • 562 citations

Z/AP, a Double Reporter for Cre-Mediated Recombination

1999 • 539 citations

Targeting of cre to the Foxg1 (BF-1) Locus Mediates loxP Recombination in the Telencephalon and Other Developing Head Structures

2000 • 535 citations

Functional expression of the cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae.

1987 • 476 citations

Conditional gene targeting.

1996 • 462 citations

Site- and Time-Specific Gene Targeting in the Mouse

2001 • 443 citations

Zp3–cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line

1997 • 359 citations

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands.

1992 • 354 citations

Studies on the properties of P1 site-specific recombination: Evidence for topologically unlinked products following recombination

1983 • 327 citations

Non-injection methods for the production of embryonic stem cell-embryo chimaeras

1993 • 286 citations

Regulation of Cre recombinase activity by the synthetic steroid RU 486

1996 • 276 citations

Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas.

2001 • 271 citations

Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes.

1996 • 271 citations

Spatio-temporally controlled site-specific somatic mutagenesis in the mouse

1997 • 245 citations

Temporal, spatial, and cell type–specific control of Cre-mediated DNA recombination in transgenic mice

1999 • 229 citations

Inducible site-specific recombination in the brain 1 1Edited by M. Yaniv

1999 • 203 citations

Temporally and spatially regulated somatic mutagenesis in mice

1998 • 187 citations

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor α mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ER ^T2 ) in adipocytes

2000 • 171 citations

Temporally controlled somatic mutagenesis in smooth muscle

2000 • 165 citations

Site-specific recombination by the bacteriophage P1 lox-Cre system

1984 • 125 citations

Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development

1996 • 120 citations

Recent advances in gene mutagenesis by site-directed recombination.

1996 • 112 citations

Tet B or not tet B: Advances in tetracycline-inducible gene expression

1999 • 108 citations

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes

2000 • 106 citations

A chimeric Cre recombinase inducible by synthetic,but not by natural ligands of the glucocorticoid receptor

1998 • 105 citations

Comparison of the Tamoxifen Regulated Chimeric Cre Recombinases MerCreMer and CreMer

1999 • 89 citations

Selective ablation of retinoid X receptor α in hepatocytes impairs their lifespan and regenerative capacity

2001 • 85 citations

Conditional genome alteration in mice

1998 • 82 citations

Early mouse development: lessons from gene targeting

1996 • 37 citations

Conditional control of gene expression in the mammary gland.

1997 • 19 citations

The right time and place for molecular scissors

1999 • 16 citations

Switching on gene expression

1997 • 12 citations