Temporal, spatial, and cell type–specific control of Cre-mediated DNA recombination in transgenic mice

Arzneimittelforschung

2005 • 8,820 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Inducible Gene Targeting in Mice

1995 • 1,897 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

1994 • 1,396 citations

Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain

1996 • 1,272 citations

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

1998 • 1,272 citations

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

1996 • 1,124 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

1996 • 858 citations

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.

1996 • 779 citations

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

1994 • 777 citations

Inducible Gene Targeting in Mice Using the Cre/loxSystem

1998 • 756 citations

Targeted oncogene activation by site-specific recombination in transgenic mice.

1992 • 687 citations

Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene

1997 • 580 citations

Recombinase-Mediated Gene Activation and Site-Specific Integration in Mammalian Cells

1991 • 564 citations

Cre-mediated gene deletion in the mammary gland

1997 • 504 citations

Improved properties of FLP recombinase evolved by cycling mutagenesis

1998 • 406 citations

An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

1998 • 377 citations

Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice.

1996 • 369 citations

Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential

1997 • 338 citations

Inducible Site-Directed Recombination in Mouse Embryonic Stem Cells

1996 • 286 citations

Regulation of Cre recombinase activity by the synthetic steroid RU 486

1996 • 276 citations

Cre-mediated somatic site-specific recombination in mice

1997 • 253 citations

Adenovirus-mediated regulable target gene expression in vivo

1999 • 249 citations

Spatio-temporally controlled site-specific somatic mutagenesis in the mouse

1997 • 245 citations

Cellular immune response to adenoviral vector infected cells does not requirede novoviral gene expression: Implications for gene therapy

1998 • 244 citations

Low‐dose doxycycline therapy: Effect on gingival and crevicular fluid collagenase activity in humans

1990 • 228 citations

Fate mapping of the mouse midbrain–hindbrain constriction using a site-specific recombination system

1998 • 214 citations

Inducible site-specific recombination in the brain 1 1Edited by M. Yaniv

1999 • 203 citations

Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination

1996 • 195 citations

Structure of the human retinoblastoma gene.

1989 • 193 citations

Temporally and spatially regulated somatic mutagenesis in mice

1998 • 187 citations

Disruption of the c/ebpα Gene in Adult Mouse liver

1997 • 180 citations

A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice.

1988 • 177 citations

Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene.

1996 • 157 citations

Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter

1996 • 151 citations

Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system

1998 • 139 citations

[28] Application of LacZ gene fusions to postimplantation development

1993 • 125 citations

RB -mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb ^+/− mice

1999 • 117 citations

Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes

1999 • 113 citations

Efficient control of gene expression by single step integration of the tetracycline system in transgenic mice

1996 • 112 citations

Inhibition of a model of in vitro granuloma formation by tetracyclines and ciprofloxacin. Involvement of protein kinase C.

1994 • 109 citations

Tet B or not tet B: Advances in tetracycline-inducible gene expression

1999 • 108 citations

Efficient Conditional Transgene Expression in Hepatitis C Virus cDNA Transgenic Mice Mediated by the Cre/loxP System

1998 • 104 citations

Regulated expression of foreign genes in vivo after germline transfer.

1994 • 86 citations

Expression of the retinoblastoma protein is regulated in normal human tissues.

1994 • 86 citations

Tissue-specific, high level expression of the rat whey acidic protien gene in transgenic mice

1990 • 84 citations

Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice.

1996 • 82 citations

Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses.

1992 • 76 citations

Inhibition of a Model of In Vitro Granuloma Formation by Tetracyclines and Ciprofloxacin

1994 • 69 citations

Expression of a retinoblastoma transgene results in dwarf mice.

1993 • 66 citations

In Vitro Release of Doxycycline From Bioabsorbable Materials and Acrylic Strips

1990 • 57 citations

Controlling your losses: conditional gene silencing in mammals

1998 • 53 citations

Efficient transgene regulation from a single tetracycline-controlled positive feedback regulatory system

1998 • 51 citations

The Effect of Local Doxycycline With and Without Tricalcium Phosphate on the Regenerative Healing Potential of Periodontal Osseous Defects in Dogs

1989 • 39 citations

Bi-directional gene switching with the tetracycline repressor and a novel tetracycline antagonist

1996 • 28 citations

Quantitative effects of the retinoblastoma gene on mouse development and tissue-specific tumorigenesis.

1993 • 26 citations

Blood and organ concentrations of tetracycline and doxycycline in female mice. Comparison to males.

1984 • 23 citations

Development of malignant fibrous histiocytoma induced by 7,12-dimethylbenz[a]anthracene in the rat: characterization of early atypical cells

1993 • 11 citations

Influence of pH and route of injection on acute toxicity of tetracycline in mice

1976 • 6 citations