Involvement of p38 MAP kinase during iron chelator-mediated apoptotic cell death

Caspases: Enemies Within

1998 • 6,923 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.

1975 • 1,734 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

An Induced Proximity Model for Caspase-8 Activation

1998 • 1,030 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Apoptosis and disease

1993 • 684 citations

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1997 • 658 citations

Components of a New Human Protein Kinase Signal Transduction Pathway

1995 • 644 citations

Cell-Permeable Peptide Inhibitors of JNK

2001 • 581 citations

Iron-induced carcinogenesis: The role of redox regulation

1996 • 556 citations

Oncoprotein Networks

1997 • 532 citations

Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

1997 • 504 citations

Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α

1998 • 382 citations

Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21^waf1/cip1, and Erythropoietin

1999 • 319 citations

Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.

1991 • 309 citations

Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153

1997 • 302 citations

Induction of Apoptosis by SB202190 through Inhibition of p38β Mitogen-activated Protein Kinase

1998 • 281 citations

Caspase‐8 in Apoptosis: The Beginning of “The End”?

2000 • 265 citations

Hydroxyl Radical as a Potential Intracellular Mediator of Polymorphonuclear Neutrophil Apoptosis

1998 • 231 citations

Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha.

1995 • 227 citations

Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.

1995 • 226 citations

p38 MAP Kinase Mediates Nitric Oxide-induced Apoptosis of Neural Progenitor Cells

2001 • 152 citations

Iron metabolism-new perspectives in view

1992 • 140 citations

Phosphorylation and Activation of both Iron Regulatory Proteins 1 and 2 in HL-60 Cells

1996 • 128 citations

THE PATIENT AND THE NHS

1984 • 117 citations

Desferioxamine increases iron depletion and apoptosis induced by ara‐C of human myeloid leukaemic cells

1998 • 116 citations

An Inhibitor of p38 and JNK MAP Kinases Prevents Activation of Caspase and Apoptosis of Cultured Cerebellar Granule Neurons

1999 • 110 citations

Overexpression of Protein Kinase C Isoforms Protects RAW 264.7 Macrophages from Nitric Oxide-Induced Apoptosis: Involvement of c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase, p38 Kinase, and CPP-32 Protease Pathways

1999 • 95 citations

Control of Transferrin Receptor Expression via Nitric Oxide-mediated Modulation of Iron-regulatory Protein 2

1999 • 93 citations

Apoptotic signal transduction: emerging pathways

1998 • 92 citations

Iron deprivation‐induced apoptosis in HL‐60 cells

1994 • 89 citations

Activation of Caspase Pathways during Iron Chelator-mediated Apoptosis

2002 • 78 citations

Ferritin and ceruloplasmin in oxidative damage: review and recent findings

1993 • 76 citations

Apoptotic signal transduction: emerging pathways

1998 • 73 citations

Sodium Nitroprusside Prevents Chemical Hypoxia‐Induced Cell Death Through Iron Ions Stimulating the Activity of the Na⁺‐Ca²⁺ Exchanger in C6 Glioma Cells

2000 • 63 citations

Inhibition of N-myc expression and induction of apoptosis by iron chelation in human neuroblastoma cells.

2001 • 62 citations

Modulation of Nitric Oxide-Induced Apoptotic Death of HL-60 Cells by Protein Kinase C and Protein Kinase A through Mitogen-Activated Protein Kinases and CPP32-like Protease Pathways

1999 • 61 citations

S-nitroso-N-acetylpenicillamine and nitroprusside induce apoptosis in a neuronal cell line by the production of different reactive molecules

2000 • 53 citations

Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3

1999 • 51 citations

Role of iron in tumor cell protection from the pro-apoptotic effect of nitric oxide.

2001 • 50 citations

Thyrotropin-releasing Hormone and Epidermal Growth Factor Regulate Iron-regulatory Protein Binding in Pituitary Cells via Protein Kinase C-dependent and -independent Signaling Pathways

2000 • 41 citations

Desferri-exochelin induces death by apoptosis in human breast cancer cells but does not kill normal breast cells

2001 • 40 citations

Human immunodeficiency virus type 1 replication inhibition by the bidentate iron chelators CP502 and CP511 is caused by proliferation inhibition and the onset of apoptosis

2002 • 38 citations

Protective effect of deferoxamine on sodium nitroprusside-induced apoptosis in PC12 cells

1998 • 29 citations

Development of Clinical Methods of Iron Deprivation for Suppression of Neoplastic and Infectious Diseases

1999 • 28 citations

Protective effect of nitric oxide against iron-induced neuronal damage

1999 • 22 citations

Deleted Work

1955 • 0 citations