Cell lineage specificity of chromatin configuration around the immunoglobulin heavy chain enhancer.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I

1980 • 1,114 citations

Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

1981 • 959 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications

1983 • 585 citations

Acute Myelogenous Leukemia: A Human Cell Line Responsive to Colony-Stimulating Activity

1978 • 537 citations

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1983 • 457 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in burkitt lymphoma

1984 • 443 citations

Regulation of Genome Rearrangement Events during Lymphocyte Differentiation

1986 • 422 citations

DNAase I-hypersensitive sites of chromatin

1981 • 410 citations

Differentiation-Linked Leukemogenesis in Lymphocytes

1986 • 359 citations

Cell-type-specific contacts to immunoglobulin enhancers in nuclei

1985 • 341 citations

Genes of the T-Cell Antigen Receptor in Normal and Malignant T Cells

1987 • 321 citations

Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence

1985 • 313 citations

Recombination between immunoglobulin variable region gene segments is enhanced by transcription

1986 • 308 citations

Immunoglobulin Heavy-Chain Enhancer Requires One or More Tissue-Specific Factors

1985 • 271 citations

Characterization of a leukemic cell line of the pre‐B phenotype

1979 • 257 citations

Cμ-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon

1985 • 232 citations

Developmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complex

1986 • 210 citations

Molecular cloning and sequence analysis of a haploid expressed gene encoding t complex polypeptide 1

1986 • 172 citations

Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.

1980 • 170 citations

Phorbol ester effect on differentiation of human myeloid leukemia cell lines blocked at different stages of maturation.

1981 • 163 citations

Heavy chain immunoglobulin gene rearrangement in acute nonlymphocytic leukemia

1984 • 163 citations

Distinct factors bind to apparently homolgous sequences in the immunoglobulin heavy-chain enhancer

1986 • 161 citations

Distribution and epitope analysis of the cell membrane glycoprotein (HPCA-1) associated with human hemopoietic progenitor cells.

1987 • 147 citations

The conserved decanucleotide from the immunoglobulin heavy chain promoter induces a very high transcriptional activity in B-cells when introduced into an heterologous promoter.

1987 • 144 citations

The Arrangement of Immunoglobulin and T Cell Receptor Genes in Human Lymphoproliferative Disorders

1987 • 138 citations

T cell receptor and immunoglobulin gene rearrangements in acute myeloblastic leukemia.

1986 • 135 citations

Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis.

1984 • 135 citations

The structure of the T cell antigen receptor genes in normal and malignant T cells

1986 • 133 citations

Deletion of the IgH enhancer does not reduce immunoglobulin heavy chain production of a hybridoma IgD class switch variant.

1984 • 127 citations

Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors.

1985 • 127 citations

Irreversible Gene Repression Model for Control of Development

1978 • 117 citations

Immunoglobulin gene organisation and expression in haemopoietic stem cell leukaemia.

1983 • 112 citations

DNase I hypersensitive sites in the chromatin of human μ immunoglobulin heavy-chain genes

1983 • 110 citations

Divergent molecular phenotypes of KG1 and KG1a myeloid cell lines

1986 • 107 citations

During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation

1986 • 105 citations

Epstein–Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements

1984 • 105 citations

Continuous in vitro generation of multipotential stem cell clones from src-infected cultures

1984 • 102 citations

Immunoglobulin and T-cell receptor gene rearrangement and expression in human lymphoid leukemia cells at different stages of maturation.

1986 • 101 citations

Lineage infidelity of a human myelogenous leukemia cell line

1984 • 79 citations

Nuclear factors binding specific sequences within the immunoglobulin enhancer interact differentially with other enhancer elements.

1986 • 73 citations

The immunoglobulin μ constant region gene is expressed in mouse thymocytes

1980 • 58 citations

Expression of T cell receptor genes in human B cells.

1986 • 48 citations

A Philadelphia chromosome positive human leukaemia cell line (NALM-1) with pre-B characteristics

1979 • 48 citations

The switch region associated with immunoglobulin Cμ genes is DNase I hypersensitive in T lymphocytes

1981 • 36 citations

Lineage specificity of rearrangement and expression of genes encoding the T cell receptor-T3 complex and immunoglobulin heavy chain in leukemia.

1987 • 33 citations