Characterization of Human Proximal Tubular Cells after Hypoxic Preconditioning: Constitutive and Hypoxia-Induced Expression of Heat Shock Proteins HSP70 (A, B, and C), HSC70, and HSP90

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.

1993 • 1,005 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury.

1995 • 859 citations

Heat Shock Is Lethal to Fibroblasts Microinjected with Antibodies Against hsp70

1988 • 635 citations

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.

1995 • 558 citations

The heat shock response is self-regulated at both the transcriptional and posttranscriptional levels

1982 • 542 citations

The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression.

1992 • 525 citations

Biochemical characterization of the mammalian stress proteins and identification of two stress proteins as glucose- and Ca2+-ionophore-regulated proteins.

1983 • 431 citations

Characterization of the thermotolerant cell. I. Effects on protein synthesis activity and the regulation of heat-shock protein 70 expression.

1988 • 399 citations

Structure and expression of the three MHC-linked HSP70 genes

1990 • 397 citations

Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity.

1992 • 376 citations

Thermal response of rat fibroblasts stably transfected with the human 70-kDa heat shock protein-encoding gene.

1991 • 365 citations

Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor

1992 • 336 citations

Nitric oxide: a mediator in rat tubularhypoxia/reoxygenation injury.

1994 • 323 citations

Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability.

1987 • 248 citations

Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs.

1995 • 238 citations

Induction of Ischemic Tolerance following Brief Focal Ischemia in Rat Brain

1994 • 223 citations

Constitutive expression of heat‐shock protein 70 in mammalian cells confers thermoresistance

1991 • 196 citations

Changes in gene expression after temporary renal ischemia

1990 • 174 citations

The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B′) and isolation of its cDNA and genomic DNA

1990 • 170 citations

Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment.

1985 • 164 citations

Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress.

1993 • 157 citations

Temporal profile of heat shock protein 70 synthesis in ischemic tolerance induced by preconditioning ischemia in rat hippocampus

1993 • 155 citations

The constitutive and stress inducible forms of hsp 70 exhibit functional similarities and interact with one another in an ATP-dependent fashion.

1993 • 148 citations

Prior ischemic stress protects against experimental stroke

1993 • 139 citations

Role of intrinsic antioxidant enzymes in renal oxidant injury

1990 • 122 citations

Response of Mammalian Cells to Metabolic Stress; Changes in Cell Physiology and Structure/Function of Stress Proteins

1991 • 103 citations

Effect of reversible ATP depletion on tight-junction integrity in LLC-PK1 cells

1991 • 102 citations

Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses

1991 • 95 citations

Energy thresholds that determine membrane integrity and injury in a renal epithelial cell line (LLC-PK1). Relationships to phospholipid degradation and unesterified fatty acid accumulation.

1988 • 91 citations

Liposomal Delivery of Purified Heat Shock Protein hsp70 Into Rat Pancreatic Islets as Protection Against Interleukin 1β–Induced Impaired β-Cell Function

1991 • 84 citations

Post-ischemic acute renal failure protects proximal tubules from O2 deprivation injury, possibly by inducing uremia

1994 • 77 citations

IGF-I binding and IGF-I mRNA expression in the post-ischemic regenerating rat kidney

1992 • 76 citations

The 90-kDa heat shock protein protects mammalian cells from thermal stress but not from viral infection*1

1991 • 57 citations

Heat shock and recovery protects renal allografts from warm ischemic injury and enhances HSP72 production.

1993 • 54 citations

Distributions of heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 mRNAs after transient focal ischemia in rat brain

1992 • 52 citations

Susceptibility of Human Proximal Tubular Cells to Hypoxia: Effect of Hypoxic Preconditioning and Comparison to Glomerular Cells

1997 • 48 citations

Stress conditioning: a novel approach to organ preservation.

1989 • 46 citations

Characteristics of long-term human epithelial cell cultures derived from normal human fetal kidney

1987 • 46 citations

Responses of the normal rat kidney to sequential ischemic events

1985 • 45 citations

Regulation of hsp70 Synthesis Induced by Cupric Sulfate and Zinc Sulfate in Thermotolerant HeLa Cells

1993 • 44 citations

Induction of heat-shock proteins does not prevent renal tubular injury following ischemia

1995 • 43 citations

The 70‐kDa Heat Shock Cognate Protein (HSC70) Is a Major Constituent of the Central Nervous System and Is Up‐Regulated Only at the mRNA Level in Acute Experimental Autoimmune Encephalomyelitis

1993 • 37 citations

LLC-PK1 epithelia as a model for in vitro assessment of proximal tubular nephrotoxicity

1995 • 31 citations

Elemental microanalysis of organelles in proximal tubules. II. Effects of oxygen deprivation.

1991 • 29 citations

Extracellular acidosis minimizes actin cytoskeletal alterations during ATP depletion

1994 • 22 citations

Effect of Extracellular Calcium on Survival of Human Proximal Tubular Cells Exposed to Hypoxia

1995 • 14 citations

Acquired resistance to acute renal failure in ischemic and uranium-induced renal failure of rabbits.

1986 • 10 citations

cAMP modulates transepithelial resistance response of LLC-PK1 renal epithelia to tumor necrosis factor

1995 • 3 citations