Biosynthesis, Processing, and Intracellular Transport of GM2 Activator Protein in Human Epidermal Keratinocytes

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

1975 • 4,443 citations

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER

1989 • 1,685 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

Proteases and biological control

1976 • 1,380 citations

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells.

1991 • 1,269 citations

Perturbation of vesicular traffic with the carboxylic ionophore monensin

1983 • 890 citations

Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes

1975 • 863 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.

1980 • 809 citations

Lysosomes in Biology and Pathology

1974 • 768 citations

Epidermal differentiation: the bare essentials.

1990 • 651 citations

Pre- and post-golgi vacuoles operate in the transport of semliki forest virus membrane glycoproteins to the cell surface

1984 • 523 citations

AB variant of infantile GM2 gangliosidosis: deficiency of a factor necessary for stimulation of hexosaminidase A-catalyzed degradation of ganglioside GM2 and glycolipid GA2.

1978 • 274 citations

Terminal differentiation of epidermal keratinocytes

1989 • 273 citations

Activator proteins and topology of lysosomal sphingolipid catabolism

1992 • 269 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

Coding of Two Sphingolipid Activator Proteins (SAP-1 and SAP-2) by Same Genetic Locus

1988 • 251 citations

Biosynthesis of lysosomal hydrolases: their synthesis in bound polysomes and the role of co- and post-translational processing in determining their subcellular distribution

1982 • 246 citations

Inhibitors of oligosaccharide processing

1985 • 218 citations

Biochemical and morphological characterization of growth and differentiation of normal human neonatal keratinocytes in a serum‐free medium

1988 • 174 citations

Structural and functional changes of lysosomal acid alpha-glucosidase during intracellular transport and maturation.

1993 • 167 citations

Theearly andlate processing of lysosomal enzymes: Proteolysis and compartmentation

1992 • 160 citations

Mannose 6-phosphate-independent membrane association of cathepsin D, glucocerebrosidase, and sphingolipid-activating protein in HepG2 cells.

1991 • 156 citations

Complexing of Glycolipids and Their Transfer between Membranes by the Activator Protein for Degradation of Lysosomal Ganglioside G_M2

1982 • 152 citations

Deficiency of UDP-N-acetylglucosamine: Lysosomal enzyme N-acetylglucosamine-1-phosphotransferase in organs of I-cell patients

1982 • 147 citations

Mannose 6-phosphate-independent targeting of lysosomal enzymes in I-cell disease B lymphoblasts.

1993 • 144 citations

Structure of Full-Length cDNA Coding for Sulfatide Activator, a Co-β-Glucosidase and Two Other Homologous Proteins: Two Alternate Forms of the Sulfatide Activator1

1989 • 134 citations

Biosynthesis of lysosomal endopeptidases

1989 • 128 citations

The Precursor of Sulfatide Activator Protein is Processed to Three Different Proteins

1988 • 114 citations

Mannose 6-phosphate-independent targeting of cathepsin D to lysosomes in HepG2 cells.

1991 • 106 citations

Isolation and sequence of a cDNA for human pro-(cathepsin L)

1988 • 98 citations

Oligosaccharides in Lysosomal Enzymes

1981 • 97 citations

Intermolecular association of lysosomal protein precursors during biosynthesis.

1994 • 97 citations

Characterization of lysosomes isolated from Dictyostelium discoideum by magnetic fractionation.

1993 • 94 citations

Procathepsins L and D are membrane-bound in acidic microsomal vesicles

1991 • 87 citations

Lysosomal enzyme oligosaccharide phosphorylation in mouse lymphoma cells: specificity and kinetics of binding to the mannose 6-phosphate receptor in vivo

1982 • 82 citations

Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits.

1988 • 79 citations

Glucocerebrosidase, a lysosomal enzyme that does not undergo oligosaccharide phosphorylation

1988 • 66 citations

Specific Mannose-6-Phosphate Receptor-Independent Sorting of Pro-Cathepsin D in Breast Cancer Cells

1994 • 64 citations

Mapping of the gene coding for the human G_M2 activator protein to chromosome 5

1985 • 58 citations

The complete amino‐acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein

1990 • 58 citations

Biosynthesis and transport of lysosomal enzymes in human monocytes and macrophages. Effects of ammonium chloride, zymosan and tunicamycin

1983 • 58 citations

Analysis of the glycosylation and phosphorylation of the lysosomal enzyme, β-hexosaminidase B, by site-directed mutagenesis

1989 • 56 citations

Effect of Tunicamycin on Transport of Lysosomal Enzymes in Cultured Skin Fibroblasts

1979 • 54 citations

Molecular genetics of GM2-gangliosidosis AB variant: a novel mutation and expression in BHK cells

1993 • 51 citations

Inhibitor studies indicate that active cathepsin L is probably essential to its own processing in cultured fibroblasts

1990 • 48 citations

Prelysosomal acidic vacuoles in Dictyostelium discoideum.

1989 • 42 citations

Intracellular Sorting of Aspartylglucosaminidase: The Role ofN-Linked Oligosaccharides and Evidence of Man-6-P-Independent Lysosomal Targeting

1995 • 40 citations

Activating Proteins for Ganglioside GM₂Degradation by β-Hexosaminidase Isoenzymes in Tissue Extracts from Different Species

1983 • 37 citations

Mistargeting of Lysosomal Enzymes in M_r 46000 Mannose 6‐phosphate Receptor‐deficient Mice is Compensated by Carbohydrate‐specific Endocytotic Receptors

1994 • 36 citations

Molecular Forms of G_M2-Activator Protein. A Study on its Biosynthesis in Human Skin Fibroblasts

1985 • 23 citations

Characterization of β-Glucosidase as a Peripheral Enzyme of Lysosomal Membranes from Mouse Liver and Purification

1985 • 19 citations

Specific Recognition of N-Acetylneuraminic Acid in the GM2 Epitope by Human GM2 Activator Protein

1995 • 18 citations

Characterization of an Alternatively Spliced GM2 Activator Protein, GM2A Protein

1996 • 13 citations

Cloning and sequence analysis of a cDNA clone coding for the mouse GM2 activator protein

1993 • 13 citations