Mast cells promote atherosclerosis by releasing proinflammatory cytokines

Inflammation in atherosclerosis

2002 • 7,873 citations

MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances

2005 • 1,216 citations

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

1999 • 937 citations

Reduction of atherosclerosis in mice by inhibition of CD40 signalling

1998 • 917 citations

Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.

1994 • 704 citations

Mast Cell-Deficient W-sash c-kit Mutant KitW-sh/W-sh Mice as a Model for Investigating Mast Cell Biology in Vivo

2005 • 573 citations

Mast Cells Can Amplify Airway Reactivity and Features of Chronic Inflammation in an Asthma Model in Mice

2000 • 400 citations

Deficiency of cathepsin S reduces atherosclerosis in LDL receptor–deficient mice

2003 • 325 citations

A Key Role for Mast Cell Chymase in the Activation of Pro-matrix Metalloprotease-9 and Pro-matrix Metalloprotease-2

2004 • 321 citations

Distinct and Nonredundant In Vivo Functions of TNF Produced by T Cells and Macrophages/Neutrophils

2005 • 318 citations

Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.

1992 • 304 citations

Deficiency of cathepsin S reduces atherosclerosis in LDL receptor–deficient mice

2003 • 297 citations

Loss of Matrix Metalloproteinase-9 or Matrix Metalloproteinase-12 Protects Apolipoprotein E–Deficient Mice Against Atherosclerotic Media Destruction but Differentially Affects Plaque Growth

2004 • 292 citations

Microscopic localization of active proteases by in situ zymography: detection of matrix metalloproteinase activity in vascular tissue

1995 • 277 citations

Activation of Matrix-Degrading Metalloproteinases by Mast Cell Proteases in Atherosclerotic Plaques

1998 • 269 citations

Deficiency of the Cysteine Protease Cathepsin S Impairs Microvessel Growth

2003 • 215 citations

The Diverse Roles of Mast Cells

2001 • 215 citations

Disruption of the Cathepsin K Gene Reduces Atherosclerosis Progression and Induces Plaque Fibrosis but Accelerates Macrophage Foam Cell Formation

2005 • 208 citations

Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand.

1992 • 208 citations

The Chymase, Mouse Mast Cell Protease 4, Constitutes the Major Chymotrypsin-like Activity in Peritoneum and Ear Tissue. A Role for Mouse Mast Cell Protease 4 in Thrombin Regulation and Fibronectin Turnover

2003 • 170 citations

MAST CELL DISTRIBUTION, ACTIVATION, AND PHENOTYPE IN ATHEROSCLEROTIC LESIONS OF HUMAN CAROTID ARTERIES

1997 • 168 citations

Mast Cells in Rupture-Prone Areas of Human Coronary Atheromas Produce and Store TNF-α

1996 • 158 citations

Tissue‐selective mast cell reconstitution and differential lung gene expression in mast cell‐deficient Kit^W‐sh/Kit^W‐sh sash mice

2005 • 154 citations

Human mast cell cytokines

1996 • 132 citations

Cathepsin L Deficiency Reduces Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor–Knockout Mice

2007 • 129 citations

Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase.

1996 • 129 citations

The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice.

1995 • 91 citations

Mast Cells and Susceptibility to Experimental Atherosclerosis

1953 • 88 citations

c-kit Gene was not transcribed in cultured mast cells of mast cell- deficient Wsh/Wsh mice that have a normal number of erythrocytes and a normal c-kit coding region

1992 • 73 citations

Molecular mechanisms regulating induction of interleukin‐6 gene transcription by interferon‐γ

1997 • 63 citations

Interferon-gamma regulation of interleukin 6 in monocytic cells

1994 • 34 citations