Chemokines in Atherosclerosis

Monocyte and macrophage heterogeneity

2005 • 4,918 citations

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

2003 • 3,265 citations

The Many Roles of Chemokines and Chemokine Receptors in Inflammation

2006 • 2,425 citations

Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion

1997 • 1,406 citations

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

2007 • 1,242 citations

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

2007 • 1,183 citations

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

2007 • 1,171 citations

Reduced Number of Circulating Endothelial Progenitor Cells Predicts Future Cardiovascular Events

2005 • 1,073 citations

Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress

2006 • 963 citations

An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4

2003 • 693 citations

Platelets as Immune Cells

2007 • 646 citations

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C ^hi and Ly6C ^lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

2008 • 623 citations

RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium

2001 • 561 citations

A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.

1998 • 525 citations

SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells

2004 • 517 citations

Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells

1999 • 475 citations

Decreased Atherosclerotic Lesion Formation in CX3CR1/Apolipoprotein E Double Knockout Mice

2003 • 465 citations

Decreased atherosclerosis in CX3CR1–/– mice reveals a role for fractalkine in atherogenesis

2003 • 460 citations

Platelets secrete stromal cell–derived factor 1α and recruit bone marrow–derived progenitor cells to arterial thrombi in vivo

2006 • 415 citations

Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

2007 • 405 citations

Differential chemokine receptor expression and function in human monocyte subpopulations

2000 • 389 citations

Antagonism of RANTES Receptors Reduces Atherosclerotic Plaque Formation in Mice

2003 • 366 citations

Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium

2005 • 361 citations

SDF-1α/CXCR4 Axis Is Instrumental in Neointimal Hyperplasia and Recruitment of Smooth Muscle Progenitor Cells

2005 • 359 citations

Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease

2001 • 348 citations

MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis

2006 • 346 citations

Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice

2006 • 334 citations

Chemokine CXCL10 Promotes Atherogenesis by Modulating the Local Balance of Effector and Regulatory T Cells

2006 • 277 citations

Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice

2006 • 273 citations

Macrophage Migration Inhibitory Factor in Cardiovascular Disease

2008 • 263 citations

CCL19 and CCL21 Induce a Potent Proinflammatory Differentiation Program in Licensed Dendritic Cells

2005 • 262 citations

Association Between Polymorphism in the Chemokine Receptor CX3CR1 and Coronary Vascular Endothelial Dysfunction and Atherosclerosis

2001 • 257 citations

Platelets and Chemokines in Atherosclerosis

2005 • 253 citations

Importance of CXC Chemokine Receptor 2 in the Homing of Human Peripheral Blood Endothelial Progenitor Cells to Sites of Arterial Injury

2007 • 244 citations

Chemokines

2004 • 244 citations

Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter.

1993 • 242 citations

Chemokines direct endothelial progenitors into tumor neovessels

2005 • 238 citations

Role of Platelets in the Development of Atherosclerosis

2004 • 233 citations

Detection of a gamma interferon-induced protein IP-10 in psoriatic plaques.

1988 • 231 citations

Fractalkine Deficiency Markedly Reduces Macrophage Accumulation and Atherosclerotic Lesion Formation in CCR2 ^−/− Mice

2007 • 225 citations

Macrophage Migration Inhibitory Factor Induces Macrophage Recruitment via CC Chemokine Ligand 2

2006 • 224 citations

Crucial Role of Stromal Cell–Derived Factor-1α in Neointima Formation After Vascular Injury in Apolipoprotein E–Deficient Mice

2003 • 202 citations

CXCL16/SR-PSOX Is an Interferon-γ–Regulated Chemokine and Scavenger Receptor Expressed in Atherosclerotic Lesions

2004 • 193 citations

IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women

2004 • 190 citations

Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root

2004 • 188 citations

Up-Regulated Expression of the CXCR2 Ligand KC/GRO-α in Atherosclerotic Lesions Plays a Central Role in Macrophage Accumulation and Lesion Progression

2006 • 181 citations

Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters

2003 • 177 citations

Transmembrane chemokines: Versatile ‘special agents’ in vascular inflammation

2007 • 176 citations

Targeted Disruption of the Scavenger Receptor and Chemokine CXCL16 Accelerates Atherosclerosis

2006 • 174 citations

Macrophage Migration Inhibitory Factor Deficiency Impairs Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

2004 • 169 citations

CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice

2003 • 168 citations

Stabilization of Atherosclerotic Plaques by Blockade of Macrophage Migration Inhibitory Factor After Vascular Injury in Apolipoprotein E–Deficient Mice

2003 • 164 citations

CX ₃ CR1 Deficiency Impairs Dendritic Cell Accumulation in Arterial Intima and Reduces Atherosclerotic Burden

2007 • 156 citations

The biological relevance of chemokine–proteoglycan interactions

2006 • 156 citations

Platelets Release CXCL4L1, a Nonallelic Variant of the Chemokine Platelet Factor-4/CXCL4 and Potent Inhibitor of Angiogenesis

2004 • 155 citations

Shear stress–induced changes in atherosclerotic plaque composition are modulated by chemokines

2007 • 154 citations

Reduced numbers of circulating endothelial progenitor cells in patients with coronary artery disease associated with long-term statin treatment

2006 • 149 citations

Chemokines in vascular remodeling

2007 • 149 citations

A Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions in Mice

2008 • 149 citations

Elimination of platelet factor 4 (PF4) from platelets reduces atherosclerosis in C57Bl/6 and apoE-/- mice

2007 • 147 citations

Differential Influence of Chemokine Receptors CCR2 and CXCR3 in Development of Atherosclerosis In Vivo

2005 • 143 citations

Chemokine Fractalkine Mediates Leukocyte Recruitment to Inflammatory Endothelial Cells in Flowing Whole Blood

2007 • 142 citations

Stromal Cell–Derived Factor-1α in Unstable Angina

2002 • 141 citations

Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10

2006 • 141 citations

Enhanced Expression of the Homeostatic Chemokines CCL19 and CCL21 in Clinical and Experimental Atherosclerosis

2006 • 135 citations

CXCR6 Promotes Atherosclerosis by Supporting T-Cell Homing, Interferon-γ Production, and Macrophage Accumulation in the Aortic Wall

2007 • 130 citations

Interleukin-8 as an independent predictor of long-term clinical outcome in patients with coronary artery disease

2007 • 129 citations

Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF)

2005 • 124 citations

Structural and functional comparison of the genes for human platelet factor 4 and PF4alt

1990 • 123 citations

CXCR3 Antagonist NBI-74330 Attenuates Atherosclerotic Plaque Formation in LDL Receptor–Deficient Mice

2007 • 117 citations

Role of Bone Marrow–Derived CC-Chemokine Receptor 5 in the Development of Atherosclerosis of Low-Density Lipoprotein Receptor Knockout Mice

2006 • 111 citations

Gene Profiling in Atherosclerosis Reveals a Key Role for Small Inducible Cytokines

2005 • 107 citations

Oligomerization of RANTES is required for CCR1-mediated arrest but not CCR5-mediated transmigration of leukocytes on inflamed endothelium

2003 • 104 citations

HIV Entry Inhibitor TAK-779 Attenuates Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice

2005 • 103 citations

Y-Box Binding Protein-1 Controls CC Chemokine Ligand-5 (CCL5) Expression in Smooth Muscle Cells and Contributes to Neointima Formation in Atherosclerosis-Prone Mice

2007 • 103 citations

Leukocyte attraction through the CCR5 receptor controls progress from insulitis to diabetes in non‐obese diabetic mice

2004 • 96 citations

Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic itinerary, resulting in retention of low-density lipoprotein on the cell surface

2002 • 96 citations

Increased Th1 activity in patients with coronary artery disease

2004 • 92 citations

Blockade of Keratinocyte-Derived Chemokine Inhibits Endothelial Recovery and Enhances Plaque Formation After Arterial Injury in ApoE-Deficient Mice

2004 • 85 citations

Fine-tuning leukocyte responses: towards a chemokine ‘interactome’

2006 • 83 citations

Constitutive expression of interferon gamma-inducible protein 10 in lymphoid organs and inducible expression in T cells and thymocytes.

1994 • 83 citations

Effects of polymorphisms in chemokine ligands and receptors on susceptibility to coronary artery disease

2006 • 77 citations

CC chemokine receptor 5 influences late-stage atherosclerosis

2007 • 76 citations

PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion

2007 • 70 citations

Chemokine Receptor CCR1 Disruption in Bone Marrow Cells Enhances Atherosclerotic Lesion Development and Inflammation in Mice

2005 • 65 citations

Fractalkine Upregulates Intercellular Adhesion Molecule-1 in Endothelial Cells Through CX3CR1 and the Jak–Stat5 Pathway

2007 • 65 citations

Chemokines in cardiovascular risk prediction

2007 • 64 citations

Stromal Cell–Derived Factor-1 and CXCR4 Interaction Is Critical for Development of Transplant Arteriosclerosis

2004 • 63 citations

A Potential Role of the CXC Chemokine GROα in Atherosclerosis and Plaque Destabilization

2008 • 60 citations

Atherogenic Lipids Induce Adhesion of Human Coronary Artery Smooth Muscle Cells to Macrophages by Up-regulating Chemokine CX3CL1 on Smooth Muscle Cells in a TNFα-NFκB-dependent Manner

2007 • 59 citations

Decreased plasma CXCL16/SR-PSOX concentration is associated with coronary artery disease

2005 • 58 citations

Identification and characterization of PF4varl, a human gene variant of platelet factor 4.

1989 • 57 citations

TLR4-NOX4-AP-1 signaling mediates lipopolysaccharide-induced CXCR6 expression in human aortic smooth muscle cells

2006 • 53 citations

Surface Expression of Fractalkine Receptor (CX3CR1) on CD4+/CD28− T Cells in RA Patients and Correlation with Atherosclerotic Damage

2007 • 52 citations

Effects of Fractalkine Receptor Variants on Common Carotid Artery Intima-Media Thickness

2006 • 50 citations

CCR7 Signaling Inhibits T Cell Proliferation

2007 • 49 citations

Opposite effects of CX3CR1 receptor polymorphisms V249I and T280M on the development of acute coronary syndrome

2005 • 47 citations

Dynamic Interplay of Transcriptional Machinery and Chromatin Regulates “Late” Expression of the Chemokine RANTES in T Lymphocytes

2006 • 40 citations

CXCR3 Chemokine Receptor - Plasma IP10 Interaction in Patients With Coronary Artery Disease

2003 • 37 citations

The CX ₃ C Chemokine Fractalkine Induces Vascular Dysfunction by Generation of Superoxide Anions

2006 • 33 citations

Functional Replacement of Murine CXCR2 by Its Human Homologue in the Development of Atherosclerosis in LDLR Knockout Mice

2007 • 8 citations