Transforming Growth Factor β Induces Caspase 3-independent Cleavage of αII-Spectrin (α-Fodrin) Coincident with Apoptosis

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1960 • 10,428 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

1992 • 675 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

1998 • 484 citations

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

1996 • 427 citations

Identification of α-Fodrin as a Candidate Autoantigen in Primary Sjögren's Syndrome

1997 • 400 citations

Molecular and Cell Biology of TGF-β

1998 • 379 citations

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

1998 • 366 citations

Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells

1998 • 307 citations

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.

1991 • 279 citations

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

1995 • 275 citations

Apoptosis Induced by Transforming Growth Factor-β in Fetal Hepatocyte Primary Cultures

1996 • 262 citations

TGFβ1 Inhibits NF-κB/Rel Activity Inducing Apoptosis of B Cells: Transcriptional Activation of IκBα

1996 • 252 citations

Immune dysregulation in TGF-beta 1-deficient mice.

1994 • 231 citations

Inhibition of Caspase-3 by S-Nitrosation and Oxidation Caused by Nitric Oxide

1997 • 212 citations

Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease

1996 • 211 citations

Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest.

1991 • 203 citations

Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse

1996 • 203 citations

In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1.

1992 • 190 citations

SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF-beta knockout mice.

1995 • 184 citations

The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells.

1994 • 182 citations

Erythroid and nonerythroid spectrins

1993 • 159 citations

Transforming growth factor beta 1 induces apoptotic cell death in cultured human gastric carcinoma cells.

1992 • 152 citations

Doxorubicin‐induced apoptosis in human T‐cell leukemia is mediated by caspase‐3 activation in a Fas‐independent way

1997 • 114 citations

Induction of apoptosis by transforming growth factor-β1 in the rat hepatoma cell line MCA-RH7777: A possible association with tissue transglutaminase expression

1993 • 113 citations

Lymphoma models for B cell activation and tolerance. X. Anti-mu-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc.

1994 • 104 citations

Characterization of transforming growth factor-beta 1 induced apoptosis in normal human B cells and lymphoma B cell lines.

1995 • 82 citations

Proteolytic processing of human brain alpha spectrin (fodrin): identification of a hypersensitive site

1988 • 82 citations

Involvement of caspase family proteases in transforming growth factor-beta-induced apoptosis.

1997 • 81 citations

A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes

1996 • 76 citations

Autoimmune Sjögren's-like lesions in salivary glands of TGF-beta1-deficient mice are inhibited by adhesion-blocking peptides.

1996 • 63 citations

Anti-immunoglobulin treatment of murine B-cell lymphomas induces active transforming growth factor beta but pRB hypophosphorylation is transforming growth factor beta independent.

1992 • 55 citations

Mechanisms of TGF-β-Induced Cell Cycle Arrest

1998 • 52 citations

TGF-β Knockout and Dominant-Negative Receptor Transgenic Mice

1998 • 51 citations

Mechanism of cytoskeletal regulation (I): functional differences correlate with antigenic dissimilarity in human brain and erythrocyte spectrin

1985 • 49 citations

ICE-like protease (caspase) is involved in transforming growth factor ?1-mediated apoptosis in FaO rat hepatoma cell line

1998 • 48 citations

Transforming growth factor-beta 1 cooperates with anti-immunoglobulin for the induction of apoptosis in group I (biopsy-like) Burkitt lymphoma cell lines

1996 • 47 citations

Up-regulation of cytokine mRNA, adhesion molecule proteins, and MHC class II proteins in salivary glands of TGF-beta1 knockout mice: MHC class II is a factor in the pathogenesis of TGF-beta1 knockout mice.

1997 • 45 citations

Characterization of apoptosis induced by transforming growth factor beta 1 in human hepatoma cells.

1994 • 42 citations

Caspase inhibitor BD-fmk distinguishes transforming growth factor beta-induced apoptosis from growth inhibition.

1998 • 35 citations

Anti-IgM induces transforming growth factor-beta sensitivity in a human B-lymphoma cell line: inhibition of growth is associated with a downregulation of mutant p53

1995 • 26 citations

Identification of a 100-kDa Phosphoprotein in Developing Murine Embryos as Elongation Factor 2

1994 • 3 citations