Definition, function and pathophysiological significance of chemokine receptors

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1996 • 1,973 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

1996 • 1,678 citations

Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion

1997 • 1,406 citations

Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES

1990 • 1,378 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.

1996 • 1,196 citations

A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

1996 • 1,125 citations

Structure and Functional Expression of a Human Interleukin-8 Receptor

1991 • 1,088 citations

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

1997 • 1,073 citations

Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor

1991 • 878 citations

B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5

1998 • 807 citations

Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor

1993 • 771 citations

Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.

1994 • 711 citations

Molecular Cloning and Functional Expression of a New Human CC-Chemokine Receptor Gene

1996 • 701 citations

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2

1997 • 671 citations

Lymphotactin: a Cytokine that Represents a New Class of Chemokine

1994 • 668 citations

Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog

1994 • 666 citations

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

1997 • 656 citations

Requirement of Mip-1α for an Inflammatory Response to Viral Infection

1995 • 636 citations

Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.

1996 • 626 citations

Potent Inhibition of HIV-1 Infectivity in Macrophages and Lymphocytes by a Novel CCR5 Antagonist

1997 • 622 citations

Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains

1996 • 619 citations

HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication

1997 • 564 citations

Cloning, expression, and characterization of the human eosinophil eotaxin receptor.

1996 • 561 citations

Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4

1997 • 556 citations

The T Cell-directed CC Chemokine TARC Is a Highly Specific Biological Ligand for CC Chemokine Receptor 4

1997 • 550 citations

Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia

1997 • 537 citations

Glycosaminoglycans Mediate Cell Surface Oligomerization of Chemokines

1997 • 512 citations

RANTES and Monocyte Chemoattractant Protein–1 (MCP-1) Play an Important Role in the Inflammatory Phase of Crescentic Nephritis, but Only MCP-1 Is Involved in Crescent Formation and Interstitial Fibrosis

1997 • 498 citations

Angiogenic and HIV-Inhibitory Functions of KSHV-Encoded Chemokines

1997 • 479 citations

A Broad-Spectrum Chemokine Antagonist Encoded by Kaposi's Sarcoma-Associated Herpesvirus

1997 • 468 citations

Impaired Host Defense, Hematopoiesis, Granulomatous Inflammation and Type 1–Type 2 Cytokine Balance in Mice Lacking CC Chemokine Receptor 1

1997 • 454 citations

Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms.

1995 • 428 citations

Extension of Recombinant Human RANTES by the Retention of the Initiating Methionine Produces a Potent Antagonist

1996 • 424 citations

Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC

1997 • 413 citations

Aminooxypentane-RANTES Induces CCR5 Internalization but Inhibits Recycling: A Novel Inhibitory Mechanism of HIV Infectivity

1998 • 409 citations

Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific Functional Ligand for EBI1, CCR7

1997 • 405 citations

A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line–tropic HIV-1 Infection

1997 • 391 citations

An Antagonist of Monocyte Chemoattractant Protein 1 (MCP-1) Inhibits Arthritis in the MRL-lpr Mouse Model

1997 • 382 citations

CCR6, a CC Chemokine Receptor that Interacts with Macrophage Inflammatory Protein 3α and Is Highly Expressed in Human Dendritic Cells

1997 • 362 citations

Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.

1993 • 349 citations

Human cytomegalovirus open reading frame US28 encodes a functional beta chemokine receptor.

1994 • 340 citations

A Small-molecule Inhibitor Directed against the Chemokine Receptor CXCR4 Prevents its Use as an HIV-1 Coreceptor

1997 • 335 citations

β-Chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

1998 • 334 citations

Identification of a promiscuous inflammatory peptide receptor on the surface of red blood cells

1993 • 292 citations

Cloning and Characterization of a Specific Receptor for the Novel CC Chemokine MIP-3α from Lung Dendritic Cells

1997 • 289 citations

Molecular Cloning and Functional Expression of a Novel CC Chemokine Receptor cDNA from a Human Basophilic Cell Line

1995 • 267 citations

Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor

1997 • 252 citations

Blockade of Chemokine Activity by a Soluble Chemokine Binding Protein from Vaccinia Virus

1998 • 252 citations

Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia.

1995 • 248 citations

Identification of CCR8: A Human Monocyte and Thymus Receptor for the CC Chemokine I-309

1997 • 237 citations

Cloning and Characterization of a Novel Promiscuous Human β-Chemokine Receptor D6

1997 • 229 citations

Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice

1997 • 219 citations

Identification and characterization of a G protein-coupled receptor homolog encoded by murine cytomegalovirus

1997 • 218 citations

Neutrophil attractant/activation protein‐1 (interleukin‐8) induces in vitro neutrophil migration by haptotactic mechanism

1993 • 215 citations

Chemokine Antagonists That Discriminate between Interleukin-8 Receptors

1997 • 124 citations

Role of MCP-1 and RANTES in inflammation and progression to fibrosis during murine crescentic nephritis

1997 • 102 citations

Prevention of endotoxemia-induced acute respiratory distress syndrome-like lung injury in rabbits by a monoclonal antibody to IL-8.

1997 • 90 citations

The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and Expressed Sequence Tag Databases

1997 • 86 citations

Mutation of Leu25 and Val27 Introduces CC Chemokine Activity into Interleukin-8

1995 • 81 citations

Pulmonary granuloma formation in the rat is partially dependent on monocyte chemoattractant protein 1.

1993 • 74 citations

Active cytomegalovirus infection of arterial smooth muscle cells in immunocompromised rats. A clue to herpesvirus-associated atherogenesis?

1994 • 55 citations

Plagiarism of the host immune system: lessons about chemokine immunology from viruses

1997 • 42 citations

HIV and chemokines: ligands sharing cell-surface receptors

1997 • 42 citations

Chemokine receptor antagonists: novel therapeutics for inflammation and AIDS

1998 • 38 citations