Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.

Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor

1995 • 714 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Protein kinases that phosphorylate activated G protein‐coupled receptors

1995 • 520 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

1993 • 467 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor

1995 • 317 citations

Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide.

1992 • 260 citations

Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C

1996 • 246 citations

Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C.

1995 • 222 citations

Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.

1994 • 220 citations

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.

1994 • 202 citations

β-Adrenergic Receptor Kinase-2 and β-Arrestin-2 as Mediators of Odorant-Induced Desensitization

1993 • 201 citations

The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain

1992 • 197 citations

Characterization of the G Protein-coupled Receptor Kinase GRK4

1996 • 193 citations

Effect of Different G Protein-coupled Receptor Kinases on Phosphorylation and Desensitization of the α1B-Adrenergic Receptor

1996 • 175 citations

Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases

1996 • 170 citations

A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination.

1993 • 146 citations

G protein .beta..gamma. subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of .alpha. subunits by pertussis toxin but differential interactions with Gs.alpha.

1989 • 139 citations

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.

1989 • 117 citations

Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization.

1994 • 95 citations

Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.

1994 • 74 citations

Pharmacological characterization of amine receptors on embryonic chick sensory neurones

1984 • 49 citations

An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.

1994 • 46 citations