Multiple site phosphorylation of tyrosine hydroxylase. Differential regulation in situ by a 8-bromo-cAMP and acetylcholine.

Radioiodination of proteins in single polyacrylamide gel slices. Tryptic peptide analysis of all the major members of complex multicomponent systems using microgram quantities of total protein.

1977 • 778 citations

Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.

1980 • 568 citations

Purification and characterization of tyrosine hydroxylase from a clonal pheochromocytoma cell line.

1980 • 292 citations

Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation.

1978 • 286 citations

Tyrosine hydroxylase: a substrate of cyclic AMP-dependent protein kinase.

1980 • 189 citations

Phosphorylation and activation of tyrosine hydroxylase mediate the cAMP-induced increase in catecholamine biosynthesis in adrenal chromaffin cells.

1982 • 177 citations

In vitro activation of rat liver phenylalanine hydroxylase by phosphorylation.

1976 • 149 citations

Involvement of Adenosine 3′,5′-Monophosphate in the Activation of Tyrosine Hydroxylase Elicited by Drugs

1973 • 126 citations

Distribution of protein I in mammalian brain as determined by a detergent-based radioimmunoassay.

1981 • 109 citations

Phosphorylation and activation of tyrosine hydroxylase mediate the acetylcholine-induced increase in catecholamine biosynthesis in adrenal chromaffin cells.

1982 • 106 citations

Characterization of an immune complex kinase in immunoprecipitates of avian sarcoma virus-transformed fibroblasts

1979 • 99 citations

Phosphorylation of Adrenal Medulla Cell Proteins in Conjunction with Stimulation of Catecholamine Secretion

1981 • 99 citations

Tyrosine Hydroxylase: Activation by Nerve Stimulation

1974 • 96 citations

Tyrosine hydroxylase: Allosteric activation induced by stimulation of central noradrenergic neurons

1975 • 87 citations

Catecholamine secretion by isolated adrenal cells

1976 • 85 citations

The rapid activation of adrenal tyrosine hydroxylase by decapitation and its relationship to a cyclic AMP-dependent phosphorylating mechanism.

1979 • 83 citations

A role for nicotinic receptors in the regulation of the adenylate cyclase of adrenal medulla.

1974 • 73 citations

Electrophoretic separation of nervous system proteins on exponential gradient polyacrylamide gels

1975 • 71 citations

Evidence that the 40,000 Mr phosphoprotein influenced by high frequency synaptic stimulation is the alpha subunit of pyruvate dehydrogenase

1981 • 65 citations

Tyrosine hydroxylase: studies on the phosphorylation of a purified preparation of the brain enzyme by the cyclic AMP-dependent protein kinase.

1981 • 61 citations

Activating antibodies to tyrosine hydroxylase.

1982 • 56 citations

Activation by cyclic 3':5'-adenosine monophosphate of tyrosine hydroxylase in the rat brain.

1975 • 54 citations

Relationship between the multiple forms of rat hepatic phenylalanine hydroxylase and degree of phosphorylation.

1980 • 52 citations

Effect of dibutyryl cyclic adenosine monophosphate on 14C-dopamine biosynthesis in rat brain striatal slices.

1974 • 52 citations

Regulatory functions of protein multisite phosphorylation

1979 • 51 citations

Striatal tyrosine hydroxylase: comparison of the activation produced by depolarization and dibutyryl-cAMP.

1979 • 49 citations

Regulation of dopamine synthesis in striatal synaptosomes during depolarization

1979 • 33 citations

The role of cyclic adenosine 3':5'-monophosphate in the regulation of tyrosine 3-monooxygenase activity.

1979 • 23 citations

Does cyclic AMP-dependent phosphorylation account for the activation of tyrosine hydroxylase produced by depolarization of central dopaminergic neurons?

1979 • 14 citations

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