Neurodegeneration and glial activation patterns after mechanical nerve injury are differentially regulated by non-MHC genes in congenic inbred rat strains

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism.

1992 • 1,121 citations

MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

1999 • 977 citations

Displacement of synaptic terminals from regenerating motoneurons by microglial cells

1968 • 845 citations

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

1993 • 832 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

Genetic Analysis of Autoimmune Disease

1996 • 739 citations

Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function

1996 • 653 citations

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

1998 • 601 citations

Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry

1992 • 588 citations

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.

1995 • 407 citations

Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ

1993 • 355 citations

Ventral root avulsion: An experimental model of death of adult motor neurons

1994 • 293 citations

Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury

1989 • 289 citations

Major Histocompatibility Complex (MHC) Class I Gene Expression in Single Neurons of the Central Nervous System: Differential Regulation by Interferon (IFN)-γ and Tumor Necrosis Factor (TNF)-α

1997 • 284 citations

Immune Surveillance in the Injured Nervous System: T-Lymphocytes Invade the Axotomized Mouse Facial Motor Nucleus and Aggregate around Sites of Neuronal Degeneration

1998 • 276 citations

Macrophage‐induced cytotoxicity of N‐methyl‐D‐aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines

1992 • 258 citations

MHC haplotype-dependent regulation of MOG-induced EAE in rats.

1998 • 257 citations

Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor‐immunoglobulin fusion proteins

1994 • 232 citations

Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus

1988 • 200 citations

Reactive mononuclear phagocytes release neurotoxins after ischemic and traumatic injury to the central nervous system

1993 • 193 citations

Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis

1995 • 181 citations

Primary demyelination in transgenic mice expressing interferon-γ

1997 • 180 citations

Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions.

1998 • 152 citations

Synthetic Alzheimer amyloid β/A4 peptides enhance production of complement C3 component by cultured microglial cells

1993 • 138 citations

Structure of the mouse glial fibrillary acidic protein gene: implications for the evolution of the intermediate filament multigene family

1985 • 138 citations

Inflammation after axonal injury has conflicting consequences for recovery of function: Rescue of spared axons is impaired but regeneration is supported

1994 • 137 citations

Gamma-interferon-like immunoreactivity in axotomized rat motor neurons

1989 • 126 citations

Evidence for Common Autoimmune Disease Genes Controlling Onset, Severity, and Chronicity Based on Experimental Models for Multiple Sclerosis and Rheumatoid Arthritis

2000 • 115 citations

Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice.

1996 • 115 citations

Rat ependyma and microglia cells express class II MHC antigens after intravenous infusion of recombinant gamma interferon

1988 • 101 citations

Inflammation and Alzheimer's Disease: Relationships between Pathogenic Mechanisms and Clinical Expression

1998 • 101 citations

Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive.

1993 • 100 citations

Neuron-glial relationship during regeneration of motorneurons

1989 • 98 citations

Advances in structural biology

1991 • 89 citations

Expression of NMDA Receptor mRNAs in Rat Motoneurons is Down‐regulated after Axotomy

1995 • 87 citations

Mapping autoimmunity genes

1999 • 83 citations

Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern

1998 • 80 citations

Expression of insulin-like growth factors and corresponding binding proteins (IGFBP 1-6) in rat spinal cord and peripheral nerve after axonal injuries

1998 • 77 citations

Upregulation of a New Microglial Gene,mrf-1, in Response to Programmed Neuronal Cell Death and Degeneration

1998 • 76 citations

Induction of C3 expression in astrocytes is regulated by cytokines and Newcastle disease virus.

1992 • 76 citations

Axotomy induces MHC class I antigen expression on rat nerve cells

1988 • 71 citations

Genome-Wide Linkage Analysis of Chronic Relapsing Experimental Autoimmune Encephalomyelitis in the Rat Identifies a Major Susceptibility Locus on Chromosome 9

1999 • 70 citations

Glial Cell Reactions in Neurodegenerative Diseases Pathophysiology and Therapeutic Interventions

1998 • 66 citations

Protective influences on experimental autoimmune encephalomyelitis by MHC class I and class II alleles.

1994 • 62 citations

Non-MHC gene regulation of nerve root injury induced spinal cord inflammation and neuron death

1999 • 49 citations

Nucleotide and deduced amino acid sequence of rat complement C3

1990 • 45 citations

Autotoxicity and Alzheimer Disease

2000 • 43 citations

Major histocompatibility complex‐controlled protective influences on experimental autoimmune encephalomyelitis are peptide specific

1997 • 37 citations

Genetics of rat neuroinflammation

2000 • 35 citations

Genetic influence on disease course and cytokine response in relapsing experimental allergic encephalomyelitis

1998 • 28 citations

Differential effect of interleukin-1β on Ia expression in astrocytes and microglia

1993 • 20 citations