Immune Surveillance in the Injured Nervous System: T-Lymphocytes Invade the Axotomized Mouse Facial Motor Nucleus and Aggregate around Sites of Neuronal Degeneration

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

T‐lymphocyte entry into the central nervous system

1991 • 1,168 citations

Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.

1948 • 1,042 citations

Functional plasticity of microglia: A review

1988 • 931 citations

Immunologically Privileged Sites

1978 • 815 citations

A Novel Geneiba1in the Major Histocompatibility Complex Class III Region Encoding an EF Hand Protein Expressed in a Monocytic Lineage

1996 • 813 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

Macrophages and microglia in the nervous system

1988 • 742 citations

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

1988 • 721 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

Microglia in degenerative neurological disease

1993 • 594 citations

Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.

1992 • 531 citations

The blood-brain barrier to proteins under normal and pathological conditions

1970 • 402 citations

Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin

1988 • 390 citations

Macromolecular permeability across the blood-nerve and blood-brain barriers.

1994 • 343 citations

Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse.

1997 • 339 citations

Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis

1993 • 295 citations

Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury

1989 • 289 citations

Impaired neuroglial activation in interleukin-6 deficient mice

1997 • 284 citations

Animal models

1994 • 276 citations

Microglia induce CD4 T lymphocyte final effector function and death.

1996 • 266 citations

Mechanisms of Immune Injury in Multiple Sclerosis

1996 • 242 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis.

1990 • 234 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination.

1990 • 229 citations

Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease.

1984 • 229 citations

The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis

1986 • 214 citations

New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury

1990 • 213 citations

Leukocyte‐Cell Adhesion: A Molecular Process Fundamental in Leukocyte Physiology

1990 • 208 citations

Interleukin‐6 and Transforming Growth Factor‐β1 mRNAs are Induced in Rat Facial Nucleus Following Motoneuron Axotomy

1993 • 205 citations

Peripheral nerve lesion produces increased levels of major histocompatibility complex antigens in the central nervous system

1989 • 189 citations

Inhibition of Posttraumatic Microglial Proliferation in a Genetic Model of Macrophage Colony‐Stimulating Factor Deficiency in the Mouse

1994 • 170 citations

Microglial response to 6-hydroxydopamine-induced substantia nigra lesions

1989 • 169 citations

Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF

1996 • 168 citations

Development of blood-brain barrier tight junctions in the rat cortex

1996 • 167 citations

Induction of Tumor Necrosis Factor-α in the Mouse Hippocampus following Transient Forebrain Ischemia

1997 • 167 citations

Effects of facial nerve injury on mouse motoneurons lacking the p75 low-affinity neurotrophin receptor

1998 • 157 citations

Electron microscopic observations on nerve cell regeneration and degeneration after axon lesions

1971 • 156 citations

Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins.

1996 • 143 citations

Regulation of thrombospondin in the regenerating mouse facial motor nucleus

1996 • 138 citations

Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response.

1994 • 132 citations

Immunocytochemical appearance of cytokines, prostaglandin E2 and lipocortin-1 in the CNS during the incubation period of murine scrapie correlates with progressive PrP accumulations

1997 • 131 citations

Anti‐Inflammatory Drugs in the Fight against Alzheimer's Diseasea

1996 • 123 citations

Detection of lysosomal cysteine proteinases in microglia: Flow cytometric measurement and histochemical localization of cathepsin B and L

1993 • 109 citations

Production of Monocyte Chemotactic Protein‐1 By Rat Brain Macrophages

1996 • 95 citations

T Lymphocyte Subpopulations and Activation Markers Correlate with Severity of Alzheimer's Disease

1995 • 92 citations

Direct demonstration of the infiltration of murine central nervous system by Pgp-1/CD44high CD45RBlow CD4+ T cells that induce experimental allergic encephalomyelitis

1992 • 91 citations

Local enhancement of major histocompatibility complex (MHC) class I and II expression and cell infiltration in experimental allergic encephalomyelitis around axotomized motor neurons

1989 • 88 citations

The balance between persistent virus infection and immune cells determines demyelination.

1996 • 86 citations

Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease

1997 • 85 citations

Facial Nerve Transection Causes Expansion of Myelin Autoreactive T Cells in Regional Lymph Nodes and T Cell Homing to the Facial Nucleus

1992 • 81 citations

Inflammation and Alzheimer disease

1996 • 78 citations

Tumor necrosis factor-α, microglia and astrocytes in AIDS dementia complex

1997 • 74 citations

The immune response in viral encephalitis.

1992 • 71 citations

Interleukin-10 downregulates the intracerebral immune response in chronic Toxoplasma encephalitis

1997 • 62 citations

Activation and re-expression of surface antigen in microglia following an epidural application of kainic acid in the rat brain.

1992 • 59 citations

Targeting of adoptively transferred experimental allergic encephalitis lesion at the sites of Wallerian degeneration

1990 • 58 citations

Intracerebral Targets and Immunomodulation of Murine Listeria monocytogenes Meningoencephalitis

1996 • 58 citations

Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity

1997 • 56 citations

Leukocyte chemotactic factor, a natural ligand to CD4, is expressed by lymphocytes and microglial cells of the MS plaque

1996 • 53 citations

Lymphocyte Recruitment Following Spinal Cord Injury in Mice is Altered by Prior Viral Exposure

1997 • 49 citations

Intercellular adhesion molecule-1 (ICAM-1) in the mouse facial motor nucleus after axonal injury and during regeneration.

1998 • 49 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination.

1990 • 48 citations

Macrophage Activation and Innate Resistance to Infection in SCID Mice

1994 • 47 citations

HLA-DR antigens associated with major genetic risk for late-onset Alzheimerʼs disease

1997 • 43 citations

Antibody-mediated clearance of viruses from the mammalian central nervous system

1993 • 42 citations

Cell adhesion molecule expression in the regenerating rat facial nucleus

1993 • 41 citations

Magnetic resonance imaging investigation of blood-brain barrier damage in adoptive transfer experimental autoimmune encephalomyelitis

1993 • 41 citations

Regulation of CD44 in the Regenerating Mouse Facial Motor Nucleus

1997 • 38 citations

Novel major histocompatibility complex expression by microglia and site-specific experimental allergic encephalomyelitis lesions in the rat central nervous system after optic nerve transection.

1993 • 32 citations

Quantitative immunohistochemistry in the rat facial nucleus with [125I]-iodinated secondary antibodies and in situ autoradiography: non-linear binding characteristics of primary monoclonal and polyclonal antibodies.

1993 • 30 citations

Higher level expression of lymphocyte function‐associated antigen‐1 (LFA‐1) on in vivo natural killer cells

1988 • 30 citations

Immune Mechanisms in the Pathogenesis of Demyelinating Diseases

1989 • 21 citations

Immune Deficiency in SCID Mice

1996 • 17 citations

Enhancing effects of irrelevant lymphocytes on adoptive transferred experimental allergic encephalomyelitis

1993 • 14 citations

Immunological Associations in Familial and Non-Familial Alzheimer Patients and Their Families

1994 • 14 citations