Antibodies that neutralize human beta interferon biologic activity recognize a linear epitope: analysis by synthetic peptide mapping.

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

1984 • 1,467 citations

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 • 1,173 citations

The Antigenic Structure of Proteins: A Reappraisal

1984 • 957 citations

Strategies for epitope analysis using peptide synthesis

1987 • 887 citations

Three-dimensional structure of a complex of antibody with influenza virus neuraminidase

1987 • 556 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

Intrinsic and Extrinsic Factors in Protein Antigenic Structure

1985 • 481 citations

The biology of the interferon system 1984

1985 • 413 citations

Target cell specificity of two species of human interferon-alpha produced in Escherichia coli and of hybrid molecules derived from them.

1981 • 190 citations

A short synthetic peptide fragment of human interleukin 1 with immunostimulatory but not inflammatory activity.

1986 • 139 citations

Efficient mapping and characterization of a T cell epitope by the simultaneous synthesis of multiple peptides

1989 • 114 citations

The Interferon system : a current review to 1987

1987 • 84 citations

The Biology of the Interferon System 1986

1987 • 81 citations

Specific binding of human alpha interferon to a high affinity cell surface binding site on bovine kidney cells.

1982 • 80 citations

Analysis of an immunodominant region of infectious bronchitis virus.

1989 • 73 citations

Structure-function relationships for the IL 2-receptor system. I. Localization of a receptor binding site on IL 2.

1986 • 62 citations

Antigenicity and Immunogenicity of Synthetic Peptides of Foot-and-Mouth Disease Virus

1987 • 60 citations

Human antibody response to a strain-specific HIV-1 gp120 epitope associated with cell fusion inhibition.

1988 • 59 citations

Bovine interferon alpha genes. Structure and expression.

1985 • 59 citations

Immunochemical mapping of .alpha.-2 interferon

1985 • 51 citations

Physicochemical and antigenic properties of synthetic fragments of human leukocyte interferon

1981 • 50 citations

Mechanisms of interferon actions

1987 • 43 citations

A single amino acid change in IFN-β1 abolishes its antiviral activity

1981 • 43 citations

Functionally important conserved amino-acids in interferon-α2 identified with analogues produced from synthetic genes

1986 • 42 citations

Specific residues within an amino-terminal domain of 35 residues of interferon alpha are responsible for recognition of the human interferon alpha cell receptor and for triggering biological effects.

1987 • 41 citations

A protective monoclonal antibody recognizes a linear epitope in the precursor to the major merozoite antigens of Plasmodium chabaudi adami.

1989 • 38 citations

Antibodies against amino acids 1-15 of tumor necrosis factor block its binding to cell-surface receptor.

1987 • 38 citations

Epitope mapping of the outer structural protein VP1 of three different serotypes of foot-and-mouth disease virus

1986 • 35 citations

Antigenic structure of sperm whale myoglobin. II. Characterization of antibodies preferentially reactive with peptides arising in response to immunization with the native protein.

1982 • 34 citations

Functional significance of amino acid residues within conserved hydrophilic regions in human interferons-α

1989 • 33 citations

Identification of immunodominant regions of transforming growth factor α

1989 • 33 citations

Biologic activity in a fragment of recombinant human interferon alpha.

1984 • 27 citations

Binding of recombinant-produced interferon beta ser to human lymphoblastoid cells. Evidence for two binding domains.

1987 • 25 citations

The antigenicity of myoglobin-related peptides synthesised on polyacrylamide and polystyrene resin supports

1984 • 24 citations

Mapping of biologically relevant sites on human IL-1 beta using monoclonal antibodies.

1988 • 23 citations

Analysis of antigenic domains on natural and recombinant human IFN-beta by the inhibition of biologic activities with monoclonal antibodies.

1989 • 20 citations

Monoclonal antipeptide antibodies recognize IL-3 and neutralize its bioactivity in vivo.

1988 • 20 citations

Synthesis and physicochemical characterization of major fragments of human leukocyte interferon .alpha.1

1984 • 16 citations

Antibodies against a peptide representative of a conserved region of human IFN-alpha. Differential effects on the antiviral and antiproliferative effects of IFN.

1989 • 14 citations

Immunochemical characterization of antigenic domains on human interferon‐β: spatially distinct epitopes are associated with both antiviral and antiproliferative activities

1990 • 13 citations

Chemical Mutagenesis of Human Interferon-β: Construction, Expression inE. coli, and Biological Activity of Sodium Bisulfite-Induced Mutations

1987 • 10 citations

Independent evolution of antiviral and growth-modulating activities of interferon.

1985 • 10 citations

Epitopes of human interferon-alpha defined by the reaction of monoclonal antibodies with alpha interferons and interferon analogues.

1987 • 8 citations

Antibodies to synthetic peptides of human interferon-beta. Use in biosynthetic studies.

1984 • 7 citations